Our Autoimmune Hepatitis Patients: Single Center Experience

Özdoğan, Osman; Yaraş, Serkan

doi:10.4274/imj.galenos.2020.23427

Cited by 2 publications

(2 citation statements)

References 32 publications

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“…On other side, the current study also recorded a highly significant differences comparison with healthy people, this finding was agreed with (Özdoğan and Yaraş, 2020), this may indicate that the majority of AIH cases tend to progress insidiously. AIH is classified as type 1 or type 2, according to differences in their autoantibodies.…”

Section: Resultssupporting

confidence: 91%

Role of signal transducer, and activator of the transcription 4 (STAT4) gene polymorphism as predictive marker for type-1 autoimmune hepatitis

Hasan

Khudhur

Hameed³

et al. 2022

ijhs

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Introduction: Autoimmune hepatitis (AIH) is one of autoimmune disorder with complex pathophysiology. Many genes involved in lethal autoimmune hepatitis disorder including STAT4 gene. The aim of this study is to determine STAT4 gene polymorphisms and relation of SNPs with disease severity among AIH patients. Method: One hundred AIH patient which diagnosed by clinically, ANA and ASMA and 100 control age matched healthy children were enrolled in this study. Patients' blood samples (5mL) were taken and split into two tubes, one tube used for immunological and clinical parameters and the second containing EDTA for PCR analysis. The first tubes were then left at room temperature for 10 minutes before being centrifuged (3500 rpm). After that, the serum was isolated the both tubes stored at -70°C until analysis, biochemical parameters were measured in full automated biochemistry analyzer while, IgG, ANA and ASMA was investigated using the enzyme-linked immunosorbent assay (ELISA) commercially available kits (Bioneer, Korea), while the STAT4 (rs7574865, rs7582694) gene was investigated using RFLP PCR How, and the commercially available kits (Bioneer, Korea).

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Section: Resultssupporting

confidence: 91%

Role of signal transducer, and activator of the transcription 4 (STAT4) gene polymorphism as predictive marker for type-1 autoimmune hepatitis

Hasan

Khudhur

Hameed³

et al. 2022

ijhs

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show abstract

“…La asociación del síndrome de Guillain-Barré con las hepatopatías autoinmunes y específicamente con colangitis biliar primaria, como la que ocurrió en nuestro paciente, es extremadamente rara y los reportes son escasos [6,7].…”

Section: Discussionunclassified

Concurrence of Guillain-Barré syndrome and primary biliary cholangitis not related to SARS-CoV-2: Case report

Segura-Chávez¹,

Tagle-Lostaunau²,

Sifuentes-Monge³

et al. 2023

Medwave

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Introduction Guillain-Barré syndrome is a polyradiculoneuropathy of autoimmune origin, considered the most frequent cause of acute flaccid paralysis. Various associations of Guillain-Barré syndrome with other non-neurological autoimmune diseases have been reported, some of them extremely rare, such as that which occurs with primary biliary cholangitis, a chronic disease of autoimmune etiology whose diagnosis is also supported by the clinical picture. , in the alteration of liver enzymes and the presence of anti-mitochondrial antibodies. Clinical case A 38-year-old male patient, with no history of previous comorbidities, who, after presenting with diarrheal disease two weeks prior, developed subacute onset ascending weakness associated with paresthesias in four extremities that progressed to quadriplegia and respiratory distress. Cerebrospinal fluid cytochemistry was performed, which showed albuminocytological dissociation and electromyography, which showed findings compatible with acute motor axonal neuropathy, for which he received treatment with intravenous immunoglobulin at 0.4g/kg/day, achieving improvement in the neurological condition. Since admission and during hospitalization, he presented persistent changes in liver enzymes which followed a cholestatic pattern, in addition to mild abdominal pain and generalized itching, for which he was evaluated by gastroenterology, who requested anti-mitochondrial antibodies that were positive. Concluding in the diagnosis of primary biliary cholangitis. Conclusion The present case shows an extremely rare association of two autoimmune diseases Guillain-Barré syndrome and primary biliary cholangitis, so much so that it represents the first case reported, not linked to SARS-CoV-2.

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Our Autoimmune Hepatitis Patients: Single Center Experience

Cited by 2 publications

References 32 publications

Role of signal transducer, and activator of the transcription 4 (STAT4) gene polymorphism as predictive marker for type-1 autoimmune hepatitis

Role of signal transducer, and activator of the transcription 4 (STAT4) gene polymorphism as predictive marker for type-1 autoimmune hepatitis

Concurrence of Guillain-Barré syndrome and primary biliary cholangitis not related to SARS-CoV-2: Case report

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