OTUD3: A Lys6 and Lys63 specific deubiquitinase in early vertebrate development

Job, Florian; Mai, Carolin; Villavicencio‐Lorini, Pablo; Herfurth, Juliane; Neuhaus, Herbert; Hoffmann, Katja; Pfirrmann, Thorsten; Hollemann, Thomas

doi:10.1016/j.bbagrm.2022.194901

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Otud3 Is An Otud-subfamily Deubiquitinase1

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2024

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Cited by 2 publications

(2 citation statements)

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“…Consistent with our prediction, knockout of otud genes in Xenopus results in developmental impairments. 48 Also, elevated expression of otud genes leads to the acquisition of stem cell properties. 49 Fatecode also predicted the negative score between thbs1 and HSPCs, where thbs1 has been shown previously to limit the expression of essential self-renewal transcription factors, including oct3 and oct4 , sox2 , klf4 , and c-myc , within cells.…”

Section: Resultsmentioning

confidence: 99%

Fatecode enables cell fate regulator prediction using classification-supervised autoencoder perturbation

Sadria,

Layton,

Goyal

et al. 2024

Cell Reports Methods

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Section: Resultsmentioning

confidence: 99%

Fatecode enables cell fate regulator prediction using classification-supervised autoencoder perturbation

Sadria,

Layton,

Goyal

et al. 2024

Cell Reports Methods

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“…Since a small fraction of OTUD3 is localized in the nucleus of non-stressed cells, it may also participate in the DNA repair pathway by counteracting Lys6 ubiquitination when it is not required. These are of course speculations and the function of OTUD3 into the nucleus needs to be further investigated ( Job et al, 2022 ).…”

Section: Otud3 Is An Otud-subfamily Deubiquitinasementioning

confidence: 99%

Deubiquitinase OTUD3: a double-edged sword in immunity and disease

Xu,

He,

Zhang

et al. 2023

Front. Cell Dev. Biol.

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Deubiquitination is an important form of post-translational modification that regulates protein homeostasis. Ovarian tumor domain-containing proteins (OTUDs) subfamily member OTUD3 was identified as a deubiquitinating enzyme involved in the regulation of various physiological processes such as immunity and inflammation. Disturbances in these physiological processes trigger diseases in humans and animals, such as cancer, neurodegenerative diseases, diabetes, mastitis, etc. OTUD3 is aberrantly expressed in tumors and is a double-edged sword, exerting tumor-promoting or anti-tumor effects in different types of tumors affecting cancer cell proliferation, metastasis, and metabolism. OTUD3 is regulated at the transcriptional level by a number of MicroRNAs, such as miR-520h, miR-32, and miR101-3p. In addition, OTUD3 is regulated by a number of post-translational modifications, such as acetylation and ubiquitination. Therefore, understanding the regulatory mechanisms of OTUD3 expression can help provide insight into its function in human immunity and disease, offering the possibility of its use as a therapeutic target to diagnose or treat disease.

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OTUD3: A Lys6 and Lys63 specific deubiquitinase in early vertebrate development

Cited by 2 publications

References 115 publications

Fatecode enables cell fate regulator prediction using classification-supervised autoencoder perturbation

Fatecode enables cell fate regulator prediction using classification-supervised autoencoder perturbation

Deubiquitinase OTUD3: a double-edged sword in immunity and disease

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