Ototoxicity May Be Associated with Protease Inhibitor Therapy

Estudo da função auditiva em indivíduos com HIV/AIDS submetidos e não submetidos à terapia antirretroviral

“…The obtained results confirmed one study in which the author, to characterize the results of audiologic assessment in children and adults with HIV/AIDS, observed higher occurrence of conductive hearing loss in children (92.9% of the cases), whereas in the adult population there was higher occurrence of sensorineural hearing loss (44.4% of the cases) (26) . Upon comparing the subjects with HIV/AIDS submitted and not submitted to antiretroviral therapy, the data observed in the present study showed that there were no differences in occurrence of hearing loss in these two groups, confirming the results of some specific studies in the area (14,19,20) , and disagreeing with other studies that correlated the use of antiretroviral medication with higher occurrence of hearing impairment (5,9,(15)(16)(17)(18)21) . Considering the data found in the present study, we could observe that sensorineural hearing loss was associated with the presence of HIV virus and its adverse effects in the infected subject, in agreement with other studies published in the literature (10)(11)(12)14,24,25) .…”

“…It is important to emphasize that the existing abnormalities may occur due to the action of the virus upon the body, the immunosuppression and presence of opportunistic infections, as well as the action of antiretroviral medication and potentially ototoxic medication (5,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)24) . The specialized literature has shown widely diversified results concerning the occurrence of hearing loss in the population with HIV/AIDS.…”

“…Even though medications are necessary and essential to many patients, providing significant improvements and increase in survival (7) , there are reports in the literature that discuss their adverse effects (8,9) . The involvement of the inner ear, resulting from the action of HIV virus, is mentioned in studies with AIDS patients (10)(11)(12)(13)(14) , which also applies to auditory disorders resulting from use of antiretroviral treatment and ototoxic medication (9,(15)(16)(17)(18)(19)(20)(21) , which may lead to sensorineural hearing loss and, consequently, irreversible inner ear damage.…”

Potenciais evocados auditivos de média e longa latências em adultos com AIDS

“…Individuals with HIV/AIDS may also present an inner ear impairment due to the direct action of the virus (Chandrasekhar et al, 2000;Mata Castro et al, 2000;Khoza & Ross, 2002), as well as to the use of anti-retroviral drugs or ototoxic medicine (Sindom et al, 2000;Williams, 2001;Rey et al, 2002), causing a sensorineural hearing loss.…”

Saúde auditiva, o vírus da imunodeficiência humana e a síndrome da imunodeficiência adquirida: uma revisão

“…Importante ressaltar a ocorrência da meningite em casos de AIDS, infecção oportunista comum entre os indivíduos com AIDS 25,26 que pode levar a um quadro de deficiên-cia auditiva neurossensorial profunda bilateral. No tratamento de pacientes aidéticos ou portadores do HIV, pode ocorrer um problema auditivo pela utilização de drogas anti-retrovirais e/ou medicamentos com potencial ototóxico [27][28][29] . Um terceiro subtema aborda especificamente o tipo de patologias observadas na população de portadores de AIDS ou HIV e esta intimamente ligado a um quarto subtema encontrado esta a busca de alternativas para avaliação audiológica da população portadora de AIDS ou HIV.…”