Otomastoiditis caused by <i>Candida auris</i>: Case report and literature review

Choi, Hyoung Il; An, Jin; Hwang, Jae Joon; Moon, Soo-youn; Son, Jun Seong

doi:10.1111/myc.12617

Cited by 37 publications

(35 citation statements)

References 17 publications

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“…Since then, sporadic cases of human infections with C. auris [27][28][29][30] Venezuela, the UK and the USA. [4][5][6][7][8][9][10][11][12][13][14][15][16][17]31 Here we report C. auris bloodstream infections from Oman, the second country on the Arabic peninsula after Kuwait 13 and confirming the fast expansion of this fungus.…”

Section: Discussionmentioning

confidence: 99%

The first cases of Candida auris candidaemia in Oman

Mohsin

Hagen

Al-Balushi

et al. 2017

Mycoses

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Candida auris has been recognised as a problematic healthcare-associated emerging yeast which is often misidentified as Candida haemulonii by commercial systems. Correct early identification of C. auris is important for appropriate antifungal treatment and implementing effective infection control measures. Here we report emergence of the first C. auris cases in Oman, initially misidentified as C. haemulonii.

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Section: Discussionmentioning

confidence: 99%

The first cases of Candida auris candidaemia in Oman

Mohsin

Hagen

Al-Balushi

et al. 2017

Mycoses

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Section: Introductionmentioning

confidence: 99%

“…Recently, the newly described yeast species Candida auris has emerged as resistant fungal pathogen responsible for hospital outbreaks, in hospitals and especially in intensive care units (ICU), in Asia, the Middle East, Africa, Latin-America, North-America and Europe. [1][2][3][4][5][6][7][8][9][10][11] C. auris has the capacity to survive in the environment for up to 2 weeks despite usual cleaning measures. This feature could be due to the use of cationic surface-active products like quaternary ammonium, disinfectants that until very recently its efficacy against this species was unknown.…”

Section: Introductionmentioning

confidence: 99%

An outbreak due to Candida auris with prolonged colonisation and candidaemia in a tertiary care European hospital

Ruiz-Gaitán

Moret

Tasias-Pitarch

et al. 2018

Mycoses

251

285

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Multidrug-resistant Candida auris has emerged as a cause of insidious hospital outbreaks and complicated infections. We present the analysis of an ongoing C. auris outbreak including the largest published series of C. auris bloodstream infection. All C. auris-positive patients from April-2016 to January-2017 were included. Environmental, clinical and microbiological data were recorded. Definitive isolate identification was performed by ITS-rDNA sequencing, and typing by amplified fragment length polymorphism fingerprinting. One hundred and forty patients were colonised by C. auris during the studied period (68% from surgical intensive care). Although control measures were implemented, we were not able to control the outbreak. Forty-one invasive bloodstream infections (87.8% from surgical intensive care) were included. Clinical management included prompt intravascular catheter removal and antifungal therapy with echinocandins. All isolates were fluconazole- and voriconazole-resistant, but echinocandin- and amphotericin B-susceptible. Thirty-day mortality rate was 41.4%, and severe septic metastasis as spondylodiscitis and endocarditis were observed in 5 patients (12%). C. auris was also recovered from inanimate patient surroundings and medical equipment. Despite antifungal treatment, high mortality and late complication rates were recorded. Molecular typing suggested a clonal outbreak different from those previously published.

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“…The rapid emergence of C. auris and the resistance to the three major classes of antifungal drugs (azoles, echinocandins and polyenes) 9 , the horizontal transmission among hospitalized patients, leading to healthcare-associated infection outbreaks, and the high mortality rates associated, make C. auris one of the most current causes of invasive infections in hospitals and reason of concern due to its evolution and worldwide spread 4 . Furthermore, fungal otomastoiditis, which is a rare and possibly fatal disease for immunosuppressed patients, has C. auris 10,11 as its etiologic agent. There have been increasing cases of otologic infection caused by C. auris 10 .…”

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confidence: 99%

“…Furthermore, fungal otomastoiditis, which is a rare and possibly fatal disease for immunosuppressed patients, has C. auris 10,11 as its etiologic agent. There have been increasing cases of otologic infection caused by C. auris 10 . Although the origin of the infections is inconclusive, it is not yet known whether these Isolates are in the hospital environment or are of endogenous origin 12 .…”

mentioning

confidence: 99%

Candida Auris: Emergence and Epidemiology of a Highly Pathogenic Yeast

Santos¹,

Lana²,

Mezzari³

2017

Clin. Biomed. Res.

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Candida auris is a multidrug-resistant emerging yeast, which was responsible for healthcare-associated infection outbreaks, and was cataloged as a new species in 2009, after being isolated from a patient's ear canal secretion in Japan. Since the notification of this first occurrence, numerous cases have been reported throughout the world, including Brazil. C. auris affects mainly inpatients, patients in intensive care units, exposed to broad-spectrum antifungal medications and who make use of vascular catheters. Currently, this yeast is one of the main responsible for invasive infections in hospitals and has been cause of concern by authorities and organs due to its rapid dissemination and difficult treatment caused by its low susceptibility to antifungal agents traditionally used in clinical practice. As a contributor to the severity of infections associated with C. auris, the transmission mechanism is still unknown, which implies in a lack of control of the microorganism and high mortality rates. Thus, this literature review presents relevant information in order to alert the importance of C. auris as an etiological agent of systemic infections, as well as its epidemiology and the real challenges of the treatment.

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Otomastoiditis caused by Candida auris: Case report and literature review

Cited by 37 publications

References 17 publications

The first cases of Candida auris candidaemia in Oman

The first cases of Candida auris candidaemia in Oman

An outbreak due to Candida auris with prolonged colonisation and candidaemia in a tertiary care European hospital

Candida Auris: Emergence and Epidemiology of a Highly Pathogenic Yeast

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