Otoimmün büllü hastalıkların klinik ve demografik özellikleri: 85 hastanın retrospektif analizi

Gül, Ülker; Kılıç, Arzu; Çakmak, Seray Külcü; Soylu, Seçil; Gönül, Müzeyyen

doi:10.4274/turkderm.78300

Cited by 2 publications

(7 citation statements)

References 21 publications

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“…Furthermore, the PV/BP ratio in our study was 0.96, and this ratio was reported to be between 1.1-1.5 in previous reports from Turkey. Although the demographic and clinical characteristics of ABD patients were in accordance with previous studies, most of the DH patients in our study were female (3,6,7,10,13). It is known that DH affects males more frequently, but the predominance of female patients was also reported if there was an accompanying autoimmune disease, as in our study (10,13).…”

Section: Discussionsupporting

confidence: 86%

“…In the literature, BP was reported as the most frequent ABD in developed countries, but in our country, it was the second most common ABD after PV. A significant increase in the number of patients has also been noted in recent years, probably due to prolongation of the lifespan (3,6,7). Furthermore, the PV/BP ratio in our study was 0.96, and this ratio was reported to be between 1.1-1.5 in previous reports from Turkey.…”

Section: Discussionsupporting

confidence: 70%

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Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Akarsu¹,

Özbağçıvan²,

Dolaş³

et al. 2017

Turk J Med Sci

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IntroductionAutoimmune bullous diseases (ABDs) are a group of rarely seen organ-specific diseases caused by pathogenic autoantibodies against target antigens that function in the intercellular or the mesenchymal/dermal junction of the epidermis. Clinically, ABDs display quite a wide spectrum of vesicle or bulla formations on the skin and/or the mucous membranes. ABDs are classified mainly as intraepidermal bullous disease (pemphigus) and subepidermal bullous diseases (pemphigoid, dermatitis herpetiformis, and acquired epidermolysis bullosa), according to the depth of blister formation on the skin and types of autoantibodies against structural proteins (1). Generally, pemphigus vulgaris (PV) and bullous pemphigoid (BP) form the greater portion of ABDs, and therefore they are the most frequently known ABDs (1,2).The demographic, clinical, and etiological characteristics of ABDs and the incidence of subgroups vary according to geographic regions (1,2). In Turkey, despite the absence of national data, the first annual incidence estimations in the Mediterranean and Aegean regions of the country were reported as 2.4 and 1.8 per million by Uzun et al. and Bozdag and Bilgin, respectively (3,4). However, it was observed that these limited numbers of published data were of retrospective nature and focused on pemphigus only (3-5). Nevertheless, one of the two recently published retrospective studies from Turkey covered pemphigus with other ABDs, and the other included patients with hereditary bullous diseases and other ABDs (6,7). In this study we aimed to evaluate demographic data, clinical characteristics, related triggering factors, and comorbidities of newly diagnosed patients with ABDs at our clinic.Background/aim: The distribution and the demographic, etiological, and clinical features of autoimmune bullous diseases (ABDs) vary according to geographic regions of the world. The limited number of reported studies in Turkey are mostly retrospective and generally include only pemphigus. The aim of our study was to evaluate the demographic data, clinical features, associated triggering factors, and comorbidities in patients newly diagnosed with ABDs. Materials and methods:In this descriptive and prospective study, the demographic data, inhabited regions, smoking and drinking habits, presence of comorbidities, and specific and general potential triggering factors of ABDs considered by the patients were examined. Furthermore, the distribution of lesions and autoimmune bullous skin disorder intensity scores were recorded.Results: Of the total 59 ABD patients, 26 (44.1%) were diagnosed with pemphigus, 25 (42.4%) were diagnosed with pemphigoid, and 8 (13.5%) were diagnosed with dermatitis herpetiformis. Although there were some differences between the subgroups of ABDs, the onset of the disease was associated with a triggering factor (stress, foods, physical trauma, chemical agents, ultraviolet rays, medications, infections, malignancies, and pregnancy, in a decreasing frequency) in 96.6% of the patients. Autoimmune diseases, ...

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 70%

Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Akarsu¹,

Özbağçıvan²,

Dolaş³

et al. 2017

Turk J Med Sci

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“…[5][6][7] In studies conducted in Turkey, in support of the literature, PV has been reported as the most frequently seen ABD, followed by BP. [1,[7][8][9] Similarly, in our study, the frequency was 51.4% for PV and 41.5% for BP.…”

Section: Discussionsupporting

confidence: 65%

“…

A utoimmune bullous diseases (ABDs) are a group of diseases characterized by vesiculobullous lesions in the mucosa and/or skin as a result of the development of autoantibodies against some target antigens present in the skin. [1,2] ABDs are divided into two main classes as intraepidermal and subepidermal ABDs depending on the level of bullae formation. The main event in intraepidermal ABDs is acantholysis, which is the separation of keratinocytes from autoantibodies developed against desmogleins, which are the intercellular adhesion molecules.

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mentioning

confidence: 99%

“…In pemphigoid group disease, target antigens are localized in the dermoepidermal junction, whereas in DH, the target antigen is epidermal transglutaminase. [1,3] In the literature, there are many studies investigating the association of ABDs with other diseases, mainly autoimmune Objectives: The purpose of the present study was to define the accompanying diseases of patients with autoimmune bullous diseases (ABDs). Methods: One hundred forty-two patients with ABD who were followed up in the dermatology and venereology inpatient clinic of Şişli Hamidiye Etfal Training and Research Hospital between January 1999 and December 2015 were enrolled in the study.…”

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confidence: 99%

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Comorbidity profiles among patients with autoimmune bullous diseases; a retrospective study

2018

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Objectives: The purpose of the present study was to define the accompanying diseases of patients with autoimmune bullous diseases (ABDs). Methods: One hundred forty-two patients with ABD who were followed up in the dermatology and venereology inpatient clinic of Şişli Hamidiye Etfal Training and Research Hospital between January 1999 and December 2015 were enrolled in the study. Age, gender, and accompanying diseases of the participants were recorded and compared with the healthy subjects. Results: Eighty patients with pemphigus, 62 patients with pemphigoid, and 217 healthy subjects were included in the study. The pemphigoid group had a statistically significant higher prevalence of hypertension, diabetes mellitus, coronary artery diseases, cataract, malignancy, dementia, Alzheimer’s disease, Parkinson’s disease, and cerebrovascular events relative to the pemphigus and control groups (p<0.01, p<0.01, p=0.001, p<0.01, p=0.02, p=0.008, p=0.001, p=0.001, and p<0.01, respectively). The prevalence of asthma, benign prostatic hyperplasia, and cataract was higher in the pemphigus group than in the controls (p=0.02, p=0.04, and p=0.02, respectively). Conclusion: To the best of our knowledge, this is the first study comparing accompanying diseases between controls and patients with pemphigus and pemphigoid. It is disputable whether the diseases mentioned occur due to some common pathophysiological pathways or coexist just coincidentally. We believe that it is important to evaluate accompanying diseases in patients with ABD.

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Otoimmün büllü hastalıkların klinik ve demografik özellikleri: 85 hastanın retrospektif analizi

Cited by 2 publications

References 21 publications

Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Comorbidity profiles among patients with autoimmune bullous diseases; a retrospective study

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