Osthole inhibits bone metastasis of breast cancer

Wu, Chun-Yu; Sun, Zhijing; Guo, Baofeng; Ye, Yiyi; Han, Xin; Qin, Yuenong; Liu, Sheng

doi:10.18632/oncotarget.17024

Cited by 29 publications

(21 citation statements)

References 31 publications

(49 reference statements)

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“…In recent years, multiple treatments have been developed for breast cancer, such as local surgical treatment, radiotherapy and chemotherapy, endocrine therapy, molecular targeted treatment, auxiliary treatment of traditional Chinese medicine and so on, which significantly improves the quality of life and prolongs the survival period of patients ( 7 – 11 ). A large number of clinical data and experimental studies have shown that the adjuvant treatment of breast cancer patients with traditional Chinese medicine can improve the body's metabolism, reduce the toxic and side effects of radiotherapy and chemotherapy, improve the surgical resection rate and endocrine therapy efficacy, and so on ( 12 , 13 ). The development of traditional Chinese medicine plays an important role in reducing the recurrence and metastasis of tumor, prolonging the survival time, and improving the quality of patients' life ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Aloperine inhibits proliferation, migration and invasion and induces apoptosis by blocking the Ras signaling pathway in human breast cancer cells

Tian

et al. 2018

Mol Med Report

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Aloperine (Alo), as a quinolizidine alkaloid extracted from S. alopecuroide, has the positive activities of anti-inflammatory, anti-allergenic, antitumor and anti-viral. However, the role and mechanism of Alo in breast cancer have not been studied yet. In the present study, Alo markedly inhibited the proliferation and suppressed the colony formation ability of the breast cancer cell lines MCF-7 and MDA-MB-231 in a dose-dependent manner by Cell Counting kit-8 and colony formation assays, respectively. In addition, the results of confocal microscopy analysis and flow cytometry detection revealed that Alo induced the apoptosis of MCF-7 and MDA-MB-231 cells, and western blotting indicated that Alo upregulated the protein levels of Bax, caspase-3 and caspase-9, and downregulated the expression of Bcl-2. Furthermore, the results of wound healing, Transwell migration and invasion assays demonstrated that Alo inhibited the migration and invasion of MCF-7 and MDA-MB-231 cells, and reduced the protein levels of matrix metalloproteinase (MMP)-2 and MMP-9. Alo also downregulated the protein expressions of Ras, phosphorylated (p)-Raf proto-oncogene, serine/threonine kinase 1 and p-extracellular signal-regulated kinase 1/2. Furthermore, ISIS 2503, a Ras inhibitor, inhibited colony formation, induced apoptosis, and suppressed the migration and invasion of MCF-7 and MDA-MB-231 cells. These effects were more marked in the presence of ISIS 2503 and Alo, when compared with those of either agent alone. In conclusion, the present study reported a novel use of Alo in inhibiting the proliferation, migration and invasion, and inducing the apoptosis of human breast cancer cells by blocking the Ras signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Aloperine inhibits proliferation, migration and invasion and induces apoptosis by blocking the Ras signaling pathway in human breast cancer cells

Tian

et al. 2018

Mol Med Report

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“…Osthole, a natural coumarin extract from the fruit of Cnidium monnieri (L.) [ 21 ], has several beneficial pharmacological properties, such as antiseizure [ 22 ], antiosteoporosis [ 23 ], and antitumour [ 24 ] activities. Recently, studies found that osthole attenuates chronic kidney failure by inhibition of inflammation [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation

Jin

Qian

et al. 2018

Mediators of Inflammation

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Inflammation is a key factor in the pathogenesis of ALI. Therefore, suppression of inflammatory response could be a potential strategy to treat LPS-induced lung injury. Osthole, a natural coumarin extract, has been reported to protect against acute kidney injury through an anti-inflammatory mechanism, but its effect on ALI is poorly understood. In this study, we investigated whether osthole ameliorates inflammatory sepsis-related ALI. Results from in vitro studies indicated that osthole treatment inhibited the LPS-induced inflammatory response in mouse peritoneal macrophages through blocking the nuclear translocation of NF-κB. Consistently, the in vivo studies indicated that osthole significantly prolonged the survival of septic mice which was accompanied by inflammation suppression. In the ALI mouse model, osthole effectively inhibited the development of lung tissue injury, leukocytic recruitment, and cytokine productions, which was associated with inhibition of NF-κB nuclear translocation. These findings provide evidence that osthole was a potent inhibitor of NF-κB and inflammatory injury and suggest that it could be a promising anti-inflammatory agent for therapy of septic shock and acute lung injury.

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“…In addition to the effects of osthol in breast cancer, this compound reduces the metastasis of this cancer to the bone marrow. In an in vivo study [ 54 ], the researchers used a mouse model to investigate the preventive effect of osthol against the metastasis of human breast cancer cells to the bone. Results showed that osthol blocked breast cancer cell growth, migration and invasion, along with enhancement of apoptosis of breast cancer cells.…”

Section: Cellular and Molecular Mechanisms Of Anticancer Effects Omentioning

confidence: 99%

Potential Anticancer Properties of Osthol: A Comprehensive Mechanistic Review

et al. 2018

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Cancer is caused by uncontrolled cell proliferation which has the potential to occur in different tissues and spread into surrounding and distant tissues. Despite the current advances in the field of anticancer agents, rapidly developing resistance against different chemotherapeutic drugs and significantly higher off-target effects cause millions of deaths every year. Osthol is a natural coumarin isolated from Apiaceaous plants which has demonstrated several pharmacological effects, such as antineoplastic, anti-inflammatory and antioxidant properties. We have attempted to summarize up-to-date information related to pharmacological effects and molecular mechanisms of osthol as a lead compound in managing malignancies. Electronic databases, including PubMed, Cochrane library, ScienceDirect and Scopus were searched for in vitro, in vivo and clinical studies on anticancer effects of osthol. Osthol exerts remarkable anticancer properties by suppressing cancer cell growth and induction of apoptosis. Osthol’s protective and therapeutic effects have been observed in different cancers, including ovarian, cervical, colon and prostate cancers as well as chronic myeloid leukemia, lung adenocarcinoma, glioma, hepatocellular, glioblastoma, renal and invasive mammary carcinoma. A large body of evidence demonstrates that osthol regulates apoptosis, proliferation and invasion in different types of malignant cells which are mediated by multiple signal transduction cascades. In this review, we set spotlights on various pathways which are targeted by osthol in different cancers to inhibit cancer development and progression.

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Osthole inhibits bone metastasis of breast cancer

Cited by 29 publications

References 31 publications

Aloperine inhibits proliferation, migration and invasion and induces apoptosis by blocking the Ras signaling pathway in human breast cancer cells

Aloperine inhibits proliferation, migration and invasion and induces apoptosis by blocking the Ras signaling pathway in human breast cancer cells

Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation

Potential Anticancer Properties of Osthol: A Comprehensive Mechanistic Review

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