Osteosarcoma with Cutaneous Metastases

Ouseph, Madhu M.; Sharan, Gautam; Sharma, Prashant; Rathi, Akanksha; Jain, Shyama; Singh, Kishore; Bahadur, Anil Kumar

doi:10.1159/000325695

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…In our study, 66% of CSM were noted over the trunk and ventrum, while the head and neck region were affected in 24% of cases. In humans, skin metastasis from OSA seems to most commonly affect the scalp . No site of predilection was apparent from the 6 cases previously reported in dogs, as CSM were noted throughout the entire body; over the thigh, hip, larynx, and tarsus; or interscapular and dorsal lumbar areas .…”

Section: Discussionmentioning

confidence: 88%

“…A majority of humans affected with CSM from OSA are reported to have had other sites of metastasis (lung, bone, lymph nodes, pleura, liver, central nervous system, etc.) detected concurrently or within 6 months . Considering the 6 previously reported cases of CSM from OSA in dogs, 2 had CSM diagnosed at the initial diagnosis with no other concomitant metastatic sites, and 4 had CSM diagnosed 1, 6, 7, and 19 months after the first metastatic event (pulmonary in all cases).…”

Section: Discussionmentioning

confidence: 95%

“…detected concurrently or within 6 months. [24][25][26][27][28][29][30][31][32] Considering the 6 previously reported cases of CSM from OSA in dogs, 2 had CSM diagnosed at the initial diagnosis with no other concomitant metastatic sites, 16,17 and 4 had CSM diagnosed 1, 18 6, 6 7, 12 and 19 12 months after the first metastatic event (pulmonary in all cases). All but 1 dog were then diagnosed with widespread metastasis within 4 months of the diagnosis of CSM.…”

Section: Discussionmentioning

confidence: 99%

“…In humans, skin metastasis from OSA seems to most commonly affect the scalp. 24,25,[28][29][30]32,35,[37][38][39][40] No site of predilection was apparent from the 6 cases previously reported in dogs, as CSM were noted throughout the entire body 16,17 ; over the thigh, 6,18 hip, larynx, and tarsus 12 ; or interscapular and dorsal lumbar areas. 18 The least common location for CSM in our study was the limbs, representing only 10% of all CSM events.…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous and subcutaneous metastasis of appendicular osteosarcoma in dogs: 20 cases

Parachini‐Winter

Curran

Pellin

et al. 2019

Veterinary Internal Medicne

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Background Metastasis of appendicular osteosarcoma is most common to the lungs and is generally considered a terminal event in dogs. Behavior and prognosis associated with cutaneous or subcutaneous metastases (CSM) is poorly defined. Objective Describe the population and gather prognostic information regarding appendicular osteosarcoma with CSM in dogs. Animals Twenty dogs with appendicular osteosarcoma and CSM. Methods Retrospective case series. Medical records were searched to identify dogs diagnosed with appendicular osteosarcoma that developed CSM. Demographic data, order of metastatic events, and CSM clinical features were evaluated. Kaplan‐Meier survival curves were constructed and log‐rank tests were used to compare survival between groups of dogs. Results In 19 dogs (95%), CSM was an incidental finding. Seventeen dogs (85%) developed pulmonary metastasis, and 1 dog (5%) developed bone metastasis. No other metastatic sites were detected before euthanasia. The median CSM‐free interval and CSM survival time were 160 days (range: 0‐542 days) and 55 days (range: 5‐336 days), respectively. The median CSM survival time was significantly longer for dogs treated with surgery and chemotherapy (94 days) or chemotherapy only (64 days) than for dogs that did not receive these treatments (11 days) (P = .002 and P = .03, respectively). No other factors were associated with survival after diagnosis of CSM. Conclusion and Clinical Importance The skin or subcutaneous tissue can be the first osteosarcoma metastatic site detected. After CSM diagnosis, the prognosis is grave with median survival <2 months. Although this finding could have been biased by case selection, treatment with surgery and chemotherapy may improve outcome.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cutaneous and subcutaneous metastasis of appendicular osteosarcoma in dogs: 20 cases

Parachini‐Winter

Curran

Pellin

et al. 2019

Veterinary Internal Medicne

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Cutaneous Metastasis of Osteosarcoma in the Scalp

Ragsdale¹,

Lehmer²,

Ragsdale³

et al. 2011

The American Journal of Dermatopathology

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As a primary malignant bone tumor, osteosarcoma is second only to chondrosarcoma. Although it commonly metastasizes and is aggressive in nature, it rarely colonizes the skin. This is a report of a 22-year-old male with osteosarcoma of the pelvis and metastasis to the lungs and chest wall who developed a clinically unsuspected solitary cutaneous metastasis in the scalp. Instead of the expected cyst, incisional biopsy disclosed a solid tan nodule of chondro-osseous sarcoma. Although rare, cutaneous metastases from osteosarcoma may appear in skin, especially the scalp, or in skin over the primary tumor. New skin lesions in a patient with a history of osteosarcoma warrant investigations including imaging and biopsy.

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