Osteosarcoma of the Larynx

Abstract

Malignant mesenchymal tumors of the larynx constitute 0.3% to 1% of all laryngeal cancers, and of these osteosarcoma is the rarest. Our review of the literature identified only 12 cases of osteosarcoma of the larynx, all of which occurred in men. Rarely, osteosarcoma of the larynx may follow radiation therapy for squamous cell carcinoma, or the larynx may be the site of metastatic osteosarcoma. We report a case of primary laryngeal osteosarcoma arising in the cricoid cartilage and the first case of osteosarcoma of the larynx occurring in a woman.

A Review of Primary Osteosarcoma of the Larynx and Case Report

“…An extensive Pubmed search resulted in only 25 published cases of primary laryngeal osteosarcoma. The mean age at presentation was 63.5 years, with an age range of 51-80 years (Table 1) [1,[5][6][7][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. In the reported cases (including the present case), only two cases occurred in females, with a male: female ratio of 13:1 (Table 1).…”

Osteosarcoma of the larynx: a case report

“…Osteosarcoma of the larynx is a very rare and aggressive tumor because of hematogenous spreading, and as it is difficult to be diagnosed [3]. Only few cases of primary larynx osteosarcomas are described in literature, and all of them have a poor prognosis.…”

“…From 1942 [1-9] to 2008 only fifteen cases were reported (M/F ratio 13:1; average age: 65). Of the fiftheen cases reported in literature, twelve were treated with surgery, two received a primary radiation therapy, and one had been treated with radiotherapy three years before for a squamous cell carcinoma of the larynx, and we do not know which therapy he was treated with [2,3]. Three of the five patients treated with radiation therapy died of disease, and no results are available about chemotherapy, as only a case received this treatment, and presented local recurrence.…”

“…Local recurrence occurred after an average time of 9.5 months [2,3]. Average time of distant spreading was 11.4 months and about 50% of the cases died of disease from 3 to 20 months after surgery [2,3].…”

Malignant mixed tumor of the larynx

“…Mesenchymal tumors occur in 0.3% to 1% of all laryngeal neoplasms. 2 Chondrosarcoma is the most common, 3 whereas the others, including fibrosarcoma, 4 rhabdomyosarcoma, 5 malignant fibrous histiocytoma, 6,7 osteosarcoma, 8 synovial sarcoma, 9 and liposarcoma, 10 are infrequent. The most common salivary gland -like tumors with laryngeal involvement are pleomorphic adenomas ( benign mixed tumors).…”