Osteosarcoma of the Larynx

Abstract

About 11,600 cases of laryngeal cancer were reported in the United States in 1995, accounting for 1% of all reported cancers. Fewer than 1% of laryngeal cancers are sarcomas, osteosarcoma being the rarest type. Twelve cases of laryngeal osteosarcoma have been cited in the literature. A 47-year-old man presented with hoarseness following a benign vocal polypectomy. The entire larynx appeared swollen, although both vocal folds moved well. Biopsies did not reveal pathologic tissue. Computed tomographic imaging revealed a destructive, expansile lesion of the thyroid cartilage. A computed tomography-guided biopsy of this cartilage revealed a high-grade sarcoma. Laryngeal osteosarcoma was diagnosed following total laryngectomy. Laryngeal osteosarcoma is a highly malignant neoplasm with early hematogenous spread. Survival statistics for peripheral osteosarcoma are poor. Limited experience reveals that a combination of surgery and radiotherapy with adjuvant chemotherapy can offer some palliation. The literature and published cases of laryngeal osteosarcoma are reviewed.

A Review of Primary Osteosarcoma of the Larynx and Case Report

“…The use of radiotherapy has been shown to be ineffective [3,4]. Adjuvant chemotherapy has been suggested in view of its use in the analogous skeletal counterpart to increase survival rates [13]. In essence, the authors submit that the diagnosis of primary laryngeal osteosarcoma in this case is justified by the meticulous morphological, immunohistochemical and ultrastructural exclusion of epithelial differentiation.…”

“…An extensive Pubmed search resulted in only 25 published cases of primary laryngeal osteosarcoma. The mean age at presentation was 63.5 years, with an age range of 51-80 years (Table 1) [1,[5][6][7][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. In the reported cases (including the present case), only two cases occurred in females, with a male: female ratio of 13:1 (Table 1).…”

Laryngeal osteosarcoma: Case report and literature review

“…Osteosarcoma of the larynx is extremely rare and demonstrates many differences from osteosarcoma of other head and neck sites. Only 24 cases of laryngeal osteosarcoma were reported from 1942 to 2009 (Table ), excluding 2 patients who were not described in detail and were lost to follow‐up shortly after surgery. Among these 24 cases, the median age at diagnosis was 64 years (range, 47–80 years), and most patients were men (92%).…”

Osteosarcoma of the larynx: rare clinical case

“…Только в 2 из всех зарегистрированных 26 случаев заболевание диагностировано у женщин (соотношение мужчин и женщин 13:1) [1][2][3][4][5][6][7][8]. Средний возраст больных составляет 63,5 года, варьирует от 51 до 80 лет [1,2,6,7,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. Этиологические факторы возникновения остеосаркомы гортани до конца не изучены, но наиболее часто упоминается воздействие ионизирующего излучения, ароматических углеводородов и онкогенных вирусов [1,2].…”

“…По данным литературы, средняя выживаемость больных составляет 12,6 ± 3,6 мес, при этом только у 23,5 % пациентов она достигает 2 лет [1]. Адъювантная химиотерапия была использована по аналогии с лечением скелетных остеосарком, данные литературы о ее результатах противоречивы и ненадежны [13]…”