Osteosarcoma in a Phthisical Feline Eye

Woog, John J.; Albert, Daniel M.; Gonder, John R.; Jl, Carpenter

doi:10.1177/030098588302000208

Cited by 40 publications

(31 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…coma of the eye, had a reported history of trauma; however, cases of post-traumatic osteosarcoma arising from the eye have been reported in cats. 39 Similarly, 10% of extraskeletal osteosarcomas in human beings develop at a site that has been i~~a d i a t e d . '~,~~ None of our dogs had a history of irradiation, but post-radiation sarcomas have been reported in dog^.^^,^^ Extraskeletal osteosarcomas in dogs are highly malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

Canine Extraskeletal Osteosarcoma and Chondrosarcoma: a Clinicopathologic Study of 14 Cases

1990

View full text Add to dashboard Cite

Abstract. Canine extraskeletal osteosarcomas are extremely rare tumors. Over a period of 25 years at the Animal Medical Center, approximately 1,000 cases of skeletal osteosarcomas have been diagnosed. During the same period 1 1 cases of extraskeletal osteosarcomas and three extraskeletal chondrosarcomas were diagnosed. Tumors of the mammary gland were excluded. Extraskeletal osteosarcomas were found in the adrenal gland, eye, gastric ligament, ileum, kidney, liver, spleen, testicle, and vagina. The chondrosarcomas were found in the mitral valves, lungs, and omentum. The mean age of the dogs with extraskeletal osteosarcoma was 11 years, and the mean age of the dogs with extraskeletal chondrosarcoma was 14 years. The sizes of the tumors ranged from 3 cubic centimeters to 8,3 15 cubic centimeters. Osteoblastic osteosarcomas were the most common histologic type (7/11, 63.6%); there was a single case of each of the following: fibroblastic, fibrous histiocytic, chondroblastic, and mixed osteo-chondroblastic osteosarcoma. Two of the dogs with chondrosarcomas had mesenchymal chondrosarcomas involving the lungs and omentum. The remaining dog had a regular chondrosarcoma involving the mitral valve. Distant metastases were present in seven of 11 dogs with extraskeletal osteosarcoma and in none of the dogs with chondrosarcoma. In contrast to human beings, in which most extraskeletal osteosarcomas occur in the soft tissues and the extremities, most canine extraskeletal osteosarcomas develop in the visceral organs.

show abstract

Section: Discussionmentioning

confidence: 99%

Canine Extraskeletal Osteosarcoma and Chondrosarcoma: a Clinicopathologic Study of 14 Cases

1990

View full text Add to dashboard Cite

show abstract

“…In 2000, Long et al [5] reported an 86-year-old woman with extraskeletal osteosarcoma following a 20-year history of phthisis bulbi secondary to multiple ocular procedures and uncontrolled glaucoma. While earlier descriptions of extraskeletal osteosarcoma arising in phthisical eyes in felines have been reported [6][7][8], Long et al's report is the only other example involving a phthisical human eye. Similar to our case, their patient's presentation included pain and proptosis.…”

Section: Discussionmentioning

confidence: 90%

Extraskeletal Osteosarcoma: A Rare Case Arising in Phthisis Bulbi with a Review of the Literature

et al. 2018

View full text Add to dashboard Cite

A 60-year-old male presented with an increasingly painful and swollen phthisical eye. Enucleation revealed a large mass obliterating the eye with extension into the adjacent extraocular muscle. Histologic examination showed high-grade osteosarcoma. Systemic work-up showed no disease elsewhere, and a diagnosis of orbital extraskeletal osteosarcoma was rendered. Complete resection was not possible, and neoadjuvant radiation was given. The patient subsequently developed pulmonary metastasis and died of disease 5 months after initial diagnosis. Given the highly aggressive nature of this malignancy, raising awareness that extraskeletal osteosarcoma may arise in the background of phthisis bulbi will facilitate timely and accurate diagnosis and treatment.

show abstract

“…The initial case was reported by one of the authors of this paper (DMA and associates) in 1983. 11 The following year, Dubielzig reported 3 cases of lens malignancy in the feline eye following ocular trauma. 12 In a subsequent study, it was established that rupture of the lens capsule was a major risk factor for development of the tumor and, on the basis of the histologic appearance, the name “feline ocular post-traumatic sarcoma” (FOPTS) was suggested.…”

Section: Resultsmentioning

confidence: 99%

“…8–10 More strikingly, malignant tumors of the lens can spontaneously occur in other species of non-human vertebrates. 11–18 During the last 25 years, considerable knowledge has accumulated regarding the “regulatory circuits” that must be disrupted in order for a cell to become malignant. The purpose of the present study was to determine in which species and, under what conditions, lens tumors occur by studying human and veterinary pathologic material available to us, combined with a review of the literature.…”

mentioning

confidence: 99%

The Significance of the Discordant Occurrence of Lens Tumors in Humans versus Other Species

Albert¹,

Phelps²,

Surapaneni³

et al. 2015

Ophthalmology

View full text Add to dashboard Cite

Purpose The purpose of this study was to determine in which species and under what conditions lens tumors occur. Design A review of data bases of available human and veterinary ocular pathological material and the previously reported literature. Participants Approximately 18,000 patients who had ocular surgical specimens submitted and studied at the University of Wisconsin School of Medicine and Public Health (UWSMPH) between 1920 and 2014 and 45,000 ocular veterinary cases from the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW) between 1983 and 2014. Methods Material in two major archived collections at the University of Wisconsin medical and veterinary schools were studied for occurrence of lens tumors. Tumor was defined as “a new growth of tissue characterized by progressive, uncontrolled proliferation of cells.” In addition, cases presented at 3 major eye pathology societies (Verhoeff-Zimmerman Ophthalmic Pathology Society, Eastern Ophthalmic Pathology Society, and The Armed Forces Institute of Pathology Ophthalmic Alumni Society) from 1975 through 2014 were reviewed. Finally, a careful search of the literature was carried out. Approval from the IRB to carry out this study was obtained. Main Outcome Measures The presence of tumors of the lens. Results The database search and literature review failed to find an example of a lens tumor in humans. In contrast, examples of naturally occurring lens tumors were found in cats, dogs, rabbits, and birds. 4.5% of feline intraocular and adnexal neoplasms (234/5153) in the veterinary school database were designated as feline ocular post-traumatic sarcoma (FOPTS), a tumor previously demonstrated to be of lens epithelial origin. Similar tumors were seen in rabbit eyes, a bird, and in a dog. All four species with lens tumors had a history of either ocular trauma or protracted uveitis. The literature search also revealed cases where lens tumors were induced in zebrafish, rainbow trout, hamsters, and mice, by carcinogenic agents (methylcholanthrene, thioacetamide), oncogenic viruses (SV40, HPV-16), and genetic manipulation. Conclusions Our results suggest that lens tumors do not occur in humans. In contrast, following lens capsule rupture, a lens tumor can occur in other species. We hypothesize that a genetic mechanism exists which prevents lens tumors in humans.

show abstract

Osteosarcoma in a Phthisical Feline Eye

Cited by 40 publications

References 12 publications

Canine Extraskeletal Osteosarcoma and Chondrosarcoma: a Clinicopathologic Study of 14 Cases

Canine Extraskeletal Osteosarcoma and Chondrosarcoma: a Clinicopathologic Study of 14 Cases

Extraskeletal Osteosarcoma: A Rare Case Arising in Phthisis Bulbi with a Review of the Literature

The Significance of the Discordant Occurrence of Lens Tumors in Humans versus Other Species

Contact Info

Product

Resources

About