Osteosarcoma and acromegaly: A case report and review of the litereture

Lima, Giovanna Aparecida Balarini; Gomes, Eliane Gonçalves; Nunes, Rodolfo de Alkmim Moreira; Neto, Leonardo Vieira; Brabo, Eloá Pereira; Gadelha, Mônica R.

doi:10.1007/bf03349215

Cited by 18 publications

(12 citation statements)

References 41 publications

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“…Buckley found no consistent relation with height in a case-control study of 152 children with osteosarcoma [23], while Gelberg found a significant positive association with height one year before diagnosis [24]. Adult patients with acromegaly have been reported to be subject to osteosarcoma [25]. In our series, one child was treated with growth hormone (GH) for 3 years before diagnosis, following intrauterine growth retardation and a polymalformative syndrome, without biological GH deficiency.…”

Section: Discussionmentioning

confidence: 84%

Clinical characteristics and prognosis of osteosarcoma in young children: a retrospective series of 15 cases

et al. 2011

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BackgroundOsteosarcoma is the most common primary bone malignancy in childhood and adolescence. However, it is very rare in children under 5 years of age. Although studies in young children are limited in number, they all underline the high rate of amputation in this population, with conflicting results being recently reported regarding their prognosis.MethodsTo enhance knowledge on the clinical characteristics and prognosis of osteosarcoma in young children, we reviewed the medical records and histology of all children diagnosed with osteosarcoma before the age of five years and treated in SFCE (Société Française des Cancers et leucémies de l'Enfant) centers between 1980 and 2007.ResultsFifteen patients from 7 centers were studied. Long bones were involved in 14 cases. Metastases were present at diagnosis in 40% of cases. The histologic type was osteoblastic in 74% of cases. Two patients had a relevant history. One child developed a second malignancy 13 years after osteosarcoma diagnosis.Thirteen children received preoperative chemotherapy including high-dose methotrexate, but only 36% had a good histologic response. Chemotherapy was well tolerated, apart from a case of severe late convulsive encephalopathy in a one-year-old infant. Limb salvage surgery was performed in six cases, with frequent mechanical and infectious complications and variable functional outcomes.Complete remission was obtained in 12 children, six of whom relapsed. With a median follow-up of 5 years, six patients were alive in remission, seven died of their disease (45%), in a broad range of 2 months to 8 years after diagnosis, two were lost to follow-up.ConclusionsOsteosarcoma seems to be more aggressive in children under five years of age, and surgical management remains a challange.

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Section: Discussionmentioning

confidence: 84%

Clinical characteristics and prognosis of osteosarcoma in young children: a retrospective series of 15 cases

et al. 2011

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“…Similarly scattered case reports exist describing various tumors including brain tumors [112][113][114], osseous tumors [115], skin epidermoid tumors and melanomas [116], adrenal tumors [117][118][119][120], and different lymphohematopietic neoplasms (lymphoma, multiple myeloma, chronic myeloid or lymphocytic leukemia) [121][122][123].…”

Section: Other Tumorsmentioning

confidence: 96%

Acromegaly: Re-thinking the cancer risk

Loeper

Ezzat

2007

Rev Endocr Metab Disord

113

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Acromegaly is characterized by sustained elevation of circulating growth hormone (GH) and insulin-like growth factor I (IGF-I), and is clearly associated with increased morbidity and overall mortality mainly due to cardiovascular, metabolic, and respiratory diseases. Although cancer-related mortality varies widely amongst retroperspective studies, it appears to be consistently elevated mainly in patients with uncontrolled disease. We review individual tumor types including neoplasms of the colon, breast, prostate, and thyroid where in vitro, animal studies, and studies in non-acromegalic cancer patients have established a role for the GH/IGF-I axis in tumor progression and possibly initiation. We highlight deficiencies in data in acromegalic patients where the evidence is less convincing. Instead, we explore the hypothesis that acromegaly, independent of hormone secretion, is a disease that heralds genetic and/or epigenetic alterations predisposing to cancer risk elsewhere.

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“…The role of growth factors and osteosarcoma is further supported by case reports of osteosarcoma occurring in individuals with acromegaly (14). It is possible that subtle variations in genes that regulate growth, such as those in the growth hormone or the insulin-like growth factor (IGF) pathways, could lead to changes in cellular signaling, altered growth, and increased risk of tumorigenesis.…”

Section: Introductionmentioning

confidence: 97%

Analysis of Genes Critical for Growth Regulation Identifies Insulin-like Growth Factor 2 Receptor Variations with Possible Functional Significance as Risk Factors for Osteosarcoma

Savage

Woodson

Walk

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Osteosarcoma, the most common malignant primary bone tumor, typically occurs during the adolescent growth spurt. Germ-line genetic variation in genes critical in growth regulation could confer altered risk of osteosarcoma. Methods: Fifty-two common single nucleotide polymorphisms (SNP) in 13 genes were genotyped in a prospective case-control study of osteosarcoma (104 osteosarcoma cases and 74 orthopedic controls). Genotype data analyzed with contingency tables suggested the strongest association with insulin-like growth factor 2 receptor (IGF2R) SNPs. Additional SNPs were genotyped to capture IGF2R common haplotypes and resequencing was done across the IGF2R block associated with osteosarcoma risk. Percentage methylation was determined by pyrosequencing of the IGF2R variant allele located in a CpG island. Results: IGF2R Ex16+88G>A (rs998075) and IVS16+15C>T (rs998074) SNPs were associated with increased risk for

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Osteosarcoma and acromegaly: A case report and review of the litereture

Cited by 18 publications

References 41 publications

Clinical characteristics and prognosis of osteosarcoma in young children: a retrospective series of 15 cases

Clinical characteristics and prognosis of osteosarcoma in young children: a retrospective series of 15 cases

Acromegaly: Re-thinking the cancer risk

Analysis of Genes Critical for Growth Regulation Identifies Insulin-like Growth Factor 2 Receptor Variations with Possible Functional Significance as Risk Factors for Osteosarcoma

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