Osteoradionecrosis: a review of pathophysiology, prevention and pharmacologic management using pentoxifylline, α-tocopherol, and clodronate

Rivero, Jose Antonio; Shamji, Omar; Kolokythas, Antonia

doi:10.1016/j.oooo.2017.08.004

Cited by 70 publications

(63 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Likewise, it has been proposed that previously noted injury-mitigating effects of pentoxifylline and dexamethasone treatments are the result of these drugs to regulate immune cell transit into radiation-damaged tissues. The combination of pentoxifylline and α-tocopherol has been demonstrated to be successful as well [114][115][116].…”

Section: Promising New Preventive/mitigative Agents Currently Under Pmentioning

confidence: 99%

“…As stated previously, radiation-induced fibrosis is a common long-term side effect of radiation damage within tissues and organ systems, including the reproductive system. There has been some experimental success in reversing induced fibrosis: treatments with agents such as copper/zinc SOD, MnSOD, or a combination of pentoxifylline and α-tocopherol [114][115][116], have shown positive results.…”

Section: Promising New Preventive/mitigative Agents Currently Under Pmentioning

confidence: 99%

See 1 more Smart Citation

Pharmacological management of ionizing radiation injuries: current and prospective agents and targeted organ systems

Singh

Seed²

2020

Expert Opinion on Pharmacotherapy

View full text Add to dashboard Cite

Introduction: There is a limited array of currently available medicinals that are useful for either the prevention, mitigation or treatment of bodily injuries arising from ionizing radiation exposure. Area covered: In this brief article, the authors review those pharmacologic agents that either are currently being used to counter the injurious effects of radiation exposure, or those that show promise and are currently under development. Expert opinion: Although significant, but limited progress has been made in the development and fielding of safe and effective pharmacotherapeutics for select types of acute radiation-associated injuries, additional effort is needed to broaden the scope of drug development so that overall health risks associated with both short-and long-term injuries in various organ systems can be reduced and effectively managed. There are several promising radiation countermeasures that may gain regulatory approval from the government in the near future for use in clinical settings and in the aftermath of nuclear/radiological exposure contingencies. ARTICLE HISTORY

show abstract

Section: Promising New Preventive/mitigative Agents Currently Under Pmentioning

confidence: 99%

Section: Promising New Preventive/mitigative Agents Currently Under Pmentioning

confidence: 99%

Pharmacological management of ionizing radiation injuries: current and prospective agents and targeted organ systems

Singh

Seed²

2020

Expert Opinion on Pharmacotherapy

View full text Add to dashboard Cite

show abstract

“…1,23,24 Adequate oral hygiene and risk reduction including abstinence from alcohol and tobacco are crucial in decreasing the risk of ORN. 23,25 Although a known risk factor for osteonecrosis, 26 there is limited data suggesting steroid use may conversely serve a protective function in ORN. 23,27 IMRT has demonstrated a lower incidence of ORN when compared with conventional RT.…”

Section: Medical Management Preventive Measuresmentioning

confidence: 99%

“…Treatment regimens aim to avoid major debilitating surgical resections, which remain a last resort. 1,[24][25][26][27] Microvascular Free Tissue Reconstruction…”

Section: Surgical Interventionmentioning

confidence: 99%

Osteoradionecrosis of the Maxilla: Conservative Management and Reconstructive Considerations

Shokri

Wang

Vincent

et al. 2020

Seminars in Plastic Surgery

View full text Add to dashboard Cite

The implementation of radiotherapy in the multimodal treatment of advanced head and neck cancer has greatly improved survival rates. In some patients, however, this benefit comes at the potential expense of the tissue surrounding the primary site of malignancy. Osteoradionecrosis (ORN) of the facial bones, in particular the maxilla, is a debilitating complication of radiation therapy. Exposure to ionizing radiation results in devitalization of underlying bone with necrosis of adjacent soft tissue. Controversy surrounding appropriate early intervention in ORN persists and no consensus for clinical treatment has been established. In the present article, we review the pathophysiology of maxillary ORN and discuss the role of both conservative medical therapy and reconstruction.

show abstract

“…The pathogenesis has been debated, and several theories exist involving that radiation results in hypoxic, hypovascular and hypocellular tissue, followed by tissue breakdown leading to a non‐healing wound. Other theories involve vascular inflammation, damage to osteoclasts and radiation‐induced fibroatrophic mechanisms with free radical formation, endothelial dysfunction, inflammation, microvascular thrombosis, fibrosis and remodelling, and finally bone and tissue necrosis …”

Section: Introductionmentioning

confidence: 99%

Follow‐up of need for dental treatment in 126 patients who have received radiation treatment to the head and neck region

Rinstad

Bergqvist

Mattsson

2019

Int J Dental Hygiene

View full text Add to dashboard Cite

show abstract

Osteoradionecrosis: a review of pathophysiology, prevention and pharmacologic management using pentoxifylline, α-tocopherol, and clodronate

Cited by 70 publications

References 44 publications

Pharmacological management of ionizing radiation injuries: current and prospective agents and targeted organ systems

Pharmacological management of ionizing radiation injuries: current and prospective agents and targeted organ systems

Osteoradionecrosis of the Maxilla: Conservative Management and Reconstructive Considerations

Follow‐up of need for dental treatment in 126 patients who have received radiation treatment to the head and neck region

Contact Info

Product

Resources

About