Osteoprotective Effects of <i>Tribulus terrestris</i> L.: Relationship Between Dehydroepiandrosterone Levels and Ca<sup>2+</sup>-Sparing Effect

Marques, Marcia Alessandra Arantes; Lourenço, Bruno Henrique Lopes Botelho; Reis, Michelle de Paula; Pauli, Karoline Bach; Soares, André Luiz de Seixas; Belettini, Salviano Tramontin; Donadel, Guilherme; Palozi, Rhanany Alan Calloi; Froehlich, Diego Lacir; Lívero, Francislaine Aparecida dos Reis; Gasparotto, Arquimedes; Lourenço, Emerson Luiz Botelho

doi:10.1089/jmf.2018.0090

Cited by 7 publications

(5 citation statements)

References 29 publications

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“…Previous work by our group [2] demonstrated that in 30 days, there was a significant bone loss, which was not observed in the present study, considering the bone structure as a whole. Although no differences were observed in the general bone structures evaluated (BMD and BMC), as shown in Figure 2, when specific regions were compared, such as pelvis and legs, which represent the bone areas of greatest impact in rodents, significant differences were observed, mainly in the legs, in relation to bone mineral content, as observed in Figure 4, demonstrating the potential of Plinia cauliflora as a protective agent of this loss.…”

Section: Discussioncontrasting

confidence: 90%

“…In Ref. [2], the authors evaluated the effect of Tribullus terrestris using the same methodology as the present study and demonstrated that increased bone mass was related to increased DHEA, respectively.…”

Section: Discussionmentioning

confidence: 94%

“…Osteoporosis (OSP) is an ancient pathology, first observed in Egypt in 990 before Christ [1]. With the aging population in Brazil, the prevalence of osteoporosis has been increasing [2]. It causes more than 8.9 million fractures per year worldwide, without previous symptoms [3].…”

Section: Introductionmentioning

confidence: 99%

“…It is a systemic, progressive, and silent disease, with osteometabolic character [2]. Physiological processes occurs permanent bone remodeling throughout the patient's life.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Plinia cauliflora effect in the prevention of osteoporosis in ovariectomized rats

Fidelis de Padua Almeida,

Donadel,

Dalmagro

et al. 2023

Osteoporosis - Pathophysiology, Diagnosis, Management and Therapy

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Osteoporosis (OSP) decreases bone mass and affects millions of people; the diagnosis is often late. Considering the side effects of conventional treatments, search for natural therapies should be a constant. Among natural treatments, herbal medicines stand out with very promising results. One of the plants that has drawn a lot of attention to prevent OSP is Plinia cauliflora (PC) Kausel. The objective was to evaluate the effect of PC extract in the OSP prevention in ovariectomized rats. In total, 60 female Wistar rats were divided into six experimental groups: positive control, negative control, sham, and three groups to test different doses (37.5, 75, and 150 mg) of PC bark extract. Bone mineral density (BMD), bone mineral content (BMC), hormone dosage, and osteocalcin were evaluated. One of the regions evaluated was the legs, where prolonged treatment with extract of PC in 75 mg, had a gain of 1.4 times of BMC. The levels of osteocalcin were found to be high at the lowest dose (37.5 mg), increasing the BMC by 70%, and moderately increasing the levels of dehydroepiandrosterone, proving that the pathway that increases BMC is through osteocalcin. PC resulted in increased BMC related mainly to increased osteocalcin, at the lowest dose preserving the bone matrix.

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Section: Discussioncontrasting

confidence: 90%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

“…It is a systemic, progressive, and silent disease, with osteometabolic character [2]. Physiological processes occurs permanent bone remodeling throughout the patient's life.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of Plinia cauliflora effect in the prevention of osteoporosis in ovariectomized rats

Fidelis de Padua Almeida,

Donadel,

Dalmagro

et al. 2023

Osteoporosis - Pathophysiology, Diagnosis, Management and Therapy

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“…Brazil has an excellent tradition in the use of different natural products, due mainly to the large diversity in plant species in their natural biomes [4]. In general, traditional preparations from medicinal plants concentrate many metabolites [5], which, despite their effectiveness, can cause significant adverse effects [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Safety Investigations of Two Formulations for Vaginal Use Obtained from Eugenia uniflora L. Leaves in Female Rats

et al. 2022

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Medicinal plants have great prominence in research into the development of new medicines. Eugenia uniflora L. (Myrtaceae) is an edible and medicinal plant with economic value in the northeast region of Brazil. Several preparations from E. uniflora leaves and its fruits are employed as a source of nutrients and bioactive compounds. In this study we evaluated the preclinical toxicology of crude extract and vaginal gel obtained from the leaves of E. uniflora (5%, 10%, and 15%) aiming to provide safety for its use in the treatment of vulvovaginitis. Both formulations were applied to the vaginal cavity for 14 days. Detailed observations of the vaginal region, including pruritus, swelling, irritation, burning, pain, and vaginal secretion, as well as the estrous cycle were evaluated. On the fifth day, blood samples were obtained from the supraorbital plexus for biochemical and hematological analyses. The animals were subsequently euthanized. All animals underwent necropsy and macroscopic examination of the vaginal mucosa and reproductive system. A histological examination was also performed. No clinically significant changes were detected during the entire experimental period. All biochemical, hematological, or histopathological parameters were within the normal range for the species. The data obtained allow us to suggest that the E. uniflora vaginal formulations are safe in this experimental model.

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Food/medicinal herbs and their influence on health and female reproduction

Sirotkin¹,

Kolesárová²

2022

Environmental Contaminants and Medicinal Plants Action on Female Reproduction

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Osteoprotective Effects of Tribulus terrestris L.: Relationship Between Dehydroepiandrosterone Levels and Ca²⁺-Sparing Effect

Cited by 7 publications

References 29 publications

Evaluation of Plinia cauliflora effect in the prevention of osteoporosis in ovariectomized rats

Evaluation of Plinia cauliflora effect in the prevention of osteoporosis in ovariectomized rats

Safety Investigations of Two Formulations for Vaginal Use Obtained from Eugenia uniflora L. Leaves in Female Rats

Food/medicinal herbs and their influence on health and female reproduction

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Osteoprotective Effects of Tribulus terrestris L.: Relationship Between Dehydroepiandrosterone Levels and Ca2+-Sparing Effect

Cited by 7 publications

References 29 publications

Evaluation of Plinia cauliflora effect in the prevention of osteoporosis in ovariectomized rats

Evaluation of Plinia cauliflora effect in the prevention of osteoporosis in ovariectomized rats

Safety Investigations of Two Formulations for Vaginal Use Obtained from Eugenia uniflora L. Leaves in Female Rats

Food/medicinal herbs and their influence on health and female reproduction

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Product

Resources

About

Osteoprotective Effects of Tribulus terrestris L.: Relationship Between Dehydroepiandrosterone Levels and Ca²⁺-Sparing Effect