Osteopromotion: A Soft‐Tissue Exclusion Principle Using a Membrane for Bone Healing and Bone Neogenesis

Linde, Anders; Alberius, Per; Dahlin, Christer; Bjurstam, Kerstin; Sundin, Yvonne

doi:10.1902/jop.1993.64.11s.1116

Cited by 153 publications

(93 citation statements)

References 12 publications

(2 reference statements)

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“…By placing biocompatible membranes of nonbiodegradable expanded polytetrafluoroethylene (ePTFE, GORE-TEX Membrane) or some type of biodegradable barrier over bone defects, it is possible to reestablish bone union as well as to create bone neogenesis (for review, see Linde et al 1 ). The membrane technique functions primarily by providing a space in which osteogenesis may take place without interference from other cell types, such as those from soft connective tissue, but also other mechanisms seem to be important.…”

Section: Introductionmentioning

confidence: 99%

Importance of delivery systems for growth-stimulatory factors in combination with osteopromotive membranes. An experimental study using rhBMP-2 in rat mandibular defects

Zellin

Linde

1997

J. Biomed. Mater. Res.

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111

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This study was undertaken to investigate whether the choice of carrier/delivery system might be crucial for rhBMP-2 induced osteogenesis beneath osteopromotive membranes. Standardized 5-mm transosseous rat mandibular defects were implanted with recombinant human BMP-2 (rhBMP-2) with or without membrane placement. Two doses of rhBMP-2 (1 microg and 8 microg per defect) were delivered with either collagen sponge or bioabsorbable poly(D,L-lactide-coglycolide) (PLA/PGA) beads plus allogenic blood as carriers. Membrane-covered defects (no BMP) served as controls. Virtually all defects treated with rhBMP-2 without membrane placement already were bridged by new bone after 12 days, independent of rhBMP-2 dose or carrier material, and lateral bone growth was extensive outside the original defect. Membrane placement significantly decreased the stimulatory activity of the BMP, as seen after 12 days, even though osteogenesis was more advanced with rhBMP-2 and membrane compared to membrane alone. After 24 days, defects treated with membrane and rhBMP-2 in the PLA/PGA carrier were totally bridged with regenerated bone, whereas defects covered with membrane without BMP implantation displayed an average bone bridging of only 53%. In an overall analysis of the bone regeneration, the PLA/PGA carrier material was found to be superior to the collagen carrier in the presence of membranes, which was, in turn, more efficient than membrane placement alone (no rhBMP-2). There was much less lateral bone growth when BMP implantation was combined with membrane placement. It was concluded that bone formation beneath osteopromotive membranes may be significantly enhanced by rhBMP-2 and that the delivery system can affect the amount of bone formation obtained. For eventual clinical use, membrane placement has the advantage of keeping the growth-stimulatory implant in place as well as obtaining the desired anatomical contour of the bone formed.

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Section: Introductionmentioning

confidence: 99%

Importance of delivery systems for growth-stimulatory factors in combination with osteopromotive membranes. An experimental study using rhBMP-2 in rat mandibular defects

Zellin

Linde

1997

J. Biomed. Mater. Res.

Self Cite

111

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“…And this regeneration is dependent on blood clot stability, local vascularization, defect size and protection against invasion of competitive nonosteogenic tissues [58,59]. Guided bone regeneration (GBR) was a technique developed to enhance bone repair, and in this procedure, an occlusive membrane is used to provide to the osteogenic cells better conditions to perform bone remodeling [60].…”

Section: Bone Remodeling and Latexmentioning

confidence: 99%

Natural Rubber Latex Biomaterials in Bone Regenerative Medicine

Kerche¹,

Cavalcante²,

EloizoJob³

2018

Biomaterials in Regenerative Medicine

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Natural rubber latex (NRL) is a white and milky solution that exudes from Hevea brasiliensis bark when perforated, and it has been appointed as a new promising biomaterial. NRL has been proven to be a very biocompatible material, and several new biomedical applications have been proposed. NRL has been proven to stimulate angiogenesis, cellular adhesion and formation of extracellular matrix, besides promoting replacement and regeneration of tissue. NRL also can be used as an occlusive membrane for guided bone regeneration (GBR) with promising results. Therefore, the aim of this chapter is to review NRL studies and to present NRL membrane as a promising biomembrane for use in bone trauma and injury.

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“…92 For example, enamel matrix derivative enhances the osteoinductive effect of demineralized freeze-dried bone allograft.…”

Section: Surgical Debridement and Bone Graftingmentioning

confidence: 99%

Peri-Implantitis: A Review of the Disease and Report of a Case Treated with Allograft to Achieve Bone Regeneration

Rashid¹,

Sheikh²,

Vohra³

et al. 2015

Dent Open J

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Dental implants offer excellent tooth replacement options however; peri-implantitis can limit their clinical success by causing failure. Peri-implantitis is an inflammatory process around dental implants resulting in bone loss in association with bleeding and suppuration. Dental plaque is at the center of its etiology, and in addition, systemic diseases, smoking, and parafunctional habits are also implicated. The pathogenic species associated with peri-implantitis include, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythia. The goal in the management of peri-implantitis is the complete resolution of peri-implant infection with function. Therapies using various biomaterials to deliver antibiotics have been used in the treatment of peri-implantitis e.g. fibers, gels, and beads. The use of guided tissue regeneration barrier membranes loaded with antimicrobials has shown success in re-osseointegrating the infected implants in animal models. Several uncertainties still remain regarding the management of peri-implantitis. The purpose of this article is to present a background of peri-implantitis along with a case of peri-implantitis successfully treated for bone regeneration.

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Osteopromotion: A Soft‐Tissue Exclusion Principle Using a Membrane for Bone Healing and Bone Neogenesis

Cited by 153 publications

References 12 publications

Importance of delivery systems for growth-stimulatory factors in combination with osteopromotive membranes. An experimental study using rhBMP-2 in rat mandibular defects

Importance of delivery systems for growth-stimulatory factors in combination with osteopromotive membranes. An experimental study using rhBMP-2 in rat mandibular defects

Natural Rubber Latex Biomaterials in Bone Regenerative Medicine

Peri-Implantitis: A Review of the Disease and Report of a Case Treated with Allograft to Achieve Bone Regeneration

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