Osteoporosis: New biomedical engineering aspects

Singh, Kanika; Lee, Sung Hak; Kim, Kyung Chun

doi:10.1007/bf02916343

Cited by 9 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, this technique has several disadvantages e.g. radiation effects, no early detection, invasive but time-consuming and unaffordable measurement [3,4]. Hence, urgent need for easy, rapid and cost-effective tools for early detection and home care of the OP just like diabetes are required.…”

Section: Introductionmentioning

confidence: 97%

“…In addition, the OP causes degradation in the bone condition especially of old persons because of increasing skeletal fragility with aging and possibly leads them to death. The medication given at right time can control the OP only if detected at the early stage [1][2][3][4]. The OP is still considered to be under-diagnosed and under-treated, hence challenges lie in identifying and understanding the totality of features and characteristics.…”

Section: Introductionmentioning

confidence: 98%

“…For example, these biomarkers are well established for the early detection of cancer [1]. Likewise, as bone metabolism is responsible for the bone condition [4][5][6][7], such biomarkers from blood analysis can be another kind of bonemarkers for predicting of the OP and bone fractures. Unfortunately, conventional blood analysis is mostly complicated, tedious and time consuming.…”

Section: Introductionmentioning

confidence: 99%

“…The degrading the bone conditions in the OP [2][3][4] is primarily due to excessive demineralization of bone, bone mineral density (BMD) has been thought as a basis for the diagnosis of the OP and typically measured by a dual-energy X-ray Absorptiometry (DXA) in the hospitals. However, this technique has several disadvantages e.g.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Spectroscopic techniques as a diagnostic tool for early detection of osteoporosis

Singh

Lee

et al. 2010

J Mech Sci Technol

Self Cite

View full text Add to dashboard Cite

Osteoporosis (OP) a kind of bone disease, is very serious in particular for old persons, and may lead them to immobility and death. Early detection of the diseases is the first consideration for the patients to have more options to live a healthy life. The biomarkers or bonemarkers provide a promising challenge in clinical proteomics for early disease detection. In this paper, optical techniques such as Fourier Transform Infrared Spectroscopy (FTIR) and UV/Visible spectroscopy are employed to find the bone markers and emphasis has been given on noninvasive modalities for early detection of osteoporosis. Blood plasma samples procured from two groups, patients and healthy persons were tested. Both of the optical techniques revealed obvious differences in the spectra; between two groups, for example, increase in intensity for OP persons. New peaks were found at 1646, 1540, 1456 and 1077 cm-1 in FTIR spectra. Except 1588 cm-1, we showed decrease in spectral intensity of OP persons. In UV/Visible spectroscopy results, new peaks appeared in the OP patients spectra at the wavelength of 279 nm and 414 nm. These differences in the spectra of the two types samples, allow rapid and cost-effective discrimination of the potential patients with the optical techniques which were verified by the bone densitometer in the hospitals. The new and novel technique is quick, reliable and effective.

show abstract

Section: Introductionmentioning

confidence: 97%