Osteoporosis Diagnosis, Management, and Referral Practice After Fragility Fractures

Snodgrass, Phillip; Zou, Anthony; Gruntmanis, Uģis; Gitajn, Ida Leah

doi:10.1007/s11914-022-00730-1

Cited by 17 publications

(15 citation statements)

References 31 publications

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“…As the population becomes older, the statistics of geriatrics diagnosed and undergoing femur fracture surgeries is sharply increasing. Femur fractures are related to a mortality rate of 6.2%–8.3% within the first 30 days postoperative and 30% mortality during one year [ 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

The Anion Gap and Mortality in Critically Ill Patients with Hip Fractures

Zhang

Shu

et al. 2022

Contrast Media & Molecular Imaging

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Objectives. Epidemiological evidence suggests that anion gap (AG) has been reported to serve as an independent predictor for mortality in different diseases. We studied the effect of AG on both short and long-term mortalities in critically ill patients with hip fracture. Methods. A large clinical database was utilized to perform retrospective cohort analysis. AG was subdivided into three groups. The Cox proportional hazards regression model was employed to approximate the hazard ratio (HR) with a confidence interval (CI) of 95% for the link between AG and mortality. 30-day mortality is the primary outcome, while 90-day and 1-year mortalities represented our secondary outcomes for this study. Results. The participants in this study were that who provided essential data on AG and the number of patients with hip fractures was 395, and they were all aged ≥16 years. The participants comprised 199 (50.4%) females as well as 196 (49.6%) males with an average age of 71.9 ± 19.4 years, and a mean AG of 12.4 ± 3.3 gmEq/L. According to an unadjusted model for 30-day all-cause mortality, the HR (95% CI) of AG ≥ 12.5 gmEq/L was 1.82 (1.11, 2.99), correspondingly, compared to the reference group (AG < 12.5 gmEq/L). This correlation was still remarkable after adjustment for r age, sex, race, SBP, DBP, WBC, heart failure, and serum chloride (HR = 1.70, 95% CI: 1.02–2.02; 2.82). For 90-day all-cause mortality, a similar correlation was observed. Conclusions. We noted that AG was an independent indicator of both short and long-term mortalities among hip fractures individuals in this retrospective single-center cohort study. AG is a simple, readily available, and inexpensive laboratory variable that can serve as a possible risk stratification tool for hip fracture.

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Section: Discussionmentioning

confidence: 99%

The Anion Gap and Mortality in Critically Ill Patients with Hip Fractures

Zhang

Shu

et al. 2022

Contrast Media & Molecular Imaging

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“…Due to population ageing, there are an increasing number of older adults living with chronic musculoskeletal conditions, particularly osteoporosis [1]. Fractures linked to osteoporosis -known as fragility fractures -are showing a rapid increase in incidence globally [2,3]. Fragility fractures most commonly occur from low-trauma injury, such as a fall from standing height or lower [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Exercise to Prevent and Manage Frailty and Fragility Fractures

Dent

Daly

Hoogendijk

et al. 2023

Curr Osteoporos Rep

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Purpose of Review This review identifies exercise-based recommendations to prevent and manage frailty and fragility fractures from current clinical practice guidelines. We also critically assess recently published literature in relation to exercise interventions to mitigate frailty and fragility fractures. Recent Findings Most guidelines presented similar recommendations that included the prescription of individually tailored, multicomponent exercise programs, discouragement of prolonged sitting and inactivity, and combining exercise with optimal nutrition. To target frailty, guidelines recommend supervised progressive resistance training (PRT). For osteoporosis and fragility fractures, exercise should include weight-bearing impact activities and PRT to target bone mineral density (BMD) at the hip and spine, and also incorporate balance and mobility training, posture exercises, and functional exercise relevant to activities of daily living to reduce falls risk. Walking as a singular intervention has limited benefits for frailty and fragility fracture prevention and management. Summary Current evidence-based clinical practice guidelines for frailty, osteoporosis, and fracture prevention recommend a multifaceted and targeted approach to optimise muscle mass, strength, power, and functional mobility as well as BMD.

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“…With the progression of an aging population worldwide, the incidence of osteoporosis is constantly increasing ( 1 ). The number of patients with osteoporosis vertebral compression fractures (OVCFs) is concurrently increasing, with the main symptoms being lower back pain and spinal deformity ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Innovative minimally invasive implants for osteoporosis vertebral compression fractures

Luo

Yang

et al. 2023

Front. Med.

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With increasing population aging, osteoporosis vertebral compression fractures (OVCFs), resulting in severe back pain and functional impairment, have become progressively common. Percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP) as minimally invasive procedures have revolutionized OVCFs treatment. However, PVP- and PKP-related complications, such as symptomatic cement leakage and adjacent vertebral fractures, continue to plague physicians. Consequently, progressively more implants for OVCFs have been developed recently to overcome the shortcomings of traditional procedures. Therefore, we conducted a literature review on several new implants for OVCFs, including StaXx FX, Vertebral Body Stenting, Vesselplasty, Sky Bone Expander, Kiva, Spine Jack, Osseofix, Optimesh, Jack, and V-strut. Additionally, this review highlights the individualized applications of these implants for OVCFs. Nevertheless, current clinical studies on these innovative implants remain limited. Future prospective, randomized, and controlled studies are needed to elucidate the effectiveness and indications of these new implants for OVCFs.

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Osteoporosis Diagnosis, Management, and Referral Practice After Fragility Fractures

Cited by 17 publications

References 31 publications

The Anion Gap and Mortality in Critically Ill Patients with Hip Fractures

The Anion Gap and Mortality in Critically Ill Patients with Hip Fractures

Exercise to Prevent and Manage Frailty and Fragility Fractures

Innovative minimally invasive implants for osteoporosis vertebral compression fractures

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