Osteoporose bei Jungtieren

Dämmrich, K

doi:10.1177/030098586700400502

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…These two puppies started showing OI clinical signs within the first 3 weeks of life, similar to the OI cases described in Golden Retrievers, Collies, Beagles, Bedlington Terrier, Dachshunds and Lagotto Romagnolos. 17,[22][23][24][25]27,29,32,33 On clinical presentation, the puppies had valgus orientation of the carpus and one also had varus orientation on the right hindlimb. There was limited range of motion on manipulation and contracture of the limbs, a finding commonly observed in human cases; however, similar perinatal limb deformities can also be associated with soft tissue or ligamentous laxity.…”

Section: Discussionmentioning

confidence: 99%

Osteogenesis Imperfecta in Two Finnish Lapphund Puppies

Tse¹,

Porter²,

Demeter

et al. 2021

VMRR

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Two 8-week-old Finnish Lapphund dogs presented with pain on manipulation, abnormal long bone conformation, retrognathism, and stunted growth compared to their litter mates. Multiple long bone fractures were evident on radiographs. Clinical pathology showed an atypically normal serum alkaline phosphatase activity for dogs this age. Due to poor quality of life, the dogs were humanely euthanized and subjected to a complete necropsy. On necropsy, all bones were soft and easily broken. Histologic examination revealed that the secondary spongiosa was diminished with abnormal bony trabeculae embedded in abundant loose vascular stroma. No Haversian canals were observed and the cortices contained abundant woven bone separated by fibrovascular tissue consistent with the diagnosis of osteogenesis imperfecta (OI). Inbreeding of the sire and female offspring led to a suspicion of recessive inheritance and the particular genetic collagen disorder remains to be identified in this breed.

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Section: Discussionmentioning

confidence: 99%

Osteogenesis Imperfecta in Two Finnish Lapphund Puppies

Tse¹,

Porter²,

Demeter

et al. 2021

VMRR

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Osteogenesis Imperfecta in Two Litters of Dachshunds

Seeliger¹,

Leeb²,

Peters³

et al. 2003

Vet Pathol

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Abstract.A clinical, morphologic, ultrastructural, and genetic study was performed on five rough-coated dachshund semisiblings with osteogenesis imperfecta (OI). Clinical signs consisted of pain, spontaneous bone and teeth fractures, joint hyperlaxity, and reduced bone density on radiography. Primary teeth were extremely thin-walled and brittle. The hallmark of the disease was a severe osteopenia characterized by impairment of lamellar bone formation in the long bones, skull, and vertebral column. No deformity or dwarfism was present. The columns of chondrocytes and primary trabeculae in the epiphyses and metaphyses were histologically normal. An abrupt failure of secondary spongiosa and lamellar bone formation was evident in the medullary and cortical zones in all animals. The few existing trabeculae consisted of woven bone. There was no increase in the number and size of osteoclasts or lacunae. In the teeth, the dentine layers were thin and lacked a tubular pattern. Ultrastructurally, osteoid apposition on bone surfaces was reduced, and small numbers of large cytoplasmic vacuoles were present in a few osteoblasts. Molecular analyses of the collagen type I-encoding genes COL1A1 and COL1A2 revealed several nucleotide differences compared with the published canine sequences but were not significant for OI. Therefore, OI in these Dachshund litters was characterized by a severe, generalized osteopenia and dentinopenia. This pattern of reduced bone formation is suggestive of defective production of collagen type I.

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Osteoporose bei Jungtieren

Cited by 2 publications

References 14 publications

Osteogenesis Imperfecta in Two Finnish Lapphund Puppies

Osteogenesis Imperfecta in Two Finnish Lapphund Puppies

Osteogenesis Imperfecta in Two Litters of Dachshunds

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