Osteopontin Serum Concentration and Metabolic Syndrome in Male Psoriatic Patients

Abstract

Psoriasis (Ps) is an immune-mediated inflammatory skin disease that is widely associated with the clinical features of metabolic syndrome (MetS), including hypertension, abdominal obesity, insulin resistance, type 2 diabetes and dyslipidemia. Osteopontin (OPN), a multifunctional protein involved in the modulation of inflammatory processes, may contribute to the development of atherosclerosis and MetS. Therefore, the aim of the study was the assessment of the correlation between OPN concentration in the peripheral blood and the presence of MetS as well as its particular components in the Ps patients. The study comprised 107 male Ps patients (50 patients with MetS and 57 without MetS) and 38 healthy volunteers (HVs). The concentration of OPN in serum was determined using enzyme-linked immunosorbent assay (ELISA) method. Fasting blood glucose and lipid profile components: total cholesterol (total CHOL), high-density lipoprotein cholesterol (HDL-CHOL), low-density lipoprotein cholesterol (LDL-CHOL), triglycerides (TG) were examined. Ps patients with MetS had significantly higher obesity, systolic blood pressure, TG, CHOL/HDL, LDL/HDL and TG/HDL ratios than Ps patients without MetS. OPN serum concentration was significantly higher in the Ps patients than in the HVs (p = 0.022) but not significantly different between the Ps patients with and without MetS (p = 0.275). OPN serum concentration in Ps patients correlated negatively with total CHOL (p = 0.004) and TG (p = 0.009). OPN is increased in Ps patients and may serve as a biomarker of some lipid abnormalities in them.

Is Metformin a Possible Beneficial Treatment for Psoriasis? A Scoping Review

“…Chronic inflammation is essential in the pathophysiology of psoriasis, being a predisposing factor for the development of other diseases, such as diabetes. Patients with psoriasis have a higher risk of developing abdominal obesity, insulin resistance, and dyslipidemia, leading to the development of metabolic syndrome [76]. Due to predisposition to obesity of patients with psoriasis and systemic inflammation, both may contribute to the development of insulin resistance and type 2 diabetes in these patients [77].…”

Special Issue: “Skin Disease and Comorbidities”

“…Psoriasis patients with MetS had significantly higher obesity, systolic blood pressure, TG, CHOL/HDL, LDL/HDL, and TG/HDL ratios than psoriasis patients without MetS. OPN serum concentration was significantly higher in psoriasis patients than in the heartly controls [14].…”

Metabolic comorbidities of psoriasis (Review)

“…Obesity is one of the comorbidities commonly associated with psoriasis; it is more prevalent among patients with severe compared with mild psoriasis, and approximately twice as common among patients with psoriasis compared with the general population, with numerous studies showing that patients with psoriasis are more frequently overweight (BMI ≥25 but <30 kg/m 2 ) or even obese (BMI ≥30 kg/m 2 ) (3,6,(12)(13)(14). Obesity is recognized as an independent risk factor for psoriasis, but is also an important risk factor for cardiovascular disease, type 2 diabetes mellitus, obstructive sleep apnea and osteoarthritis, and it is a leading cause of premature death, with recent population-based studies showing an increasing number of adults and children affected (12,(15)(16)(17)(18)(19). It has long remained unclear whether obesity is a risk factor for the development of psoriasis or its consequence.…”

“…One of the most significant comorbidities found in patients with psoriasis is the metabolic syndrome, a pathological condition with a wide range of manifestations, such as visceral obesity, insulin resistance/elevated fasting glucose level, dyslipidemia (elevated LDL-cholesterol, decreased HDL-cholesterol and elevated triglyceride levels) and hypertension, which represent major risk factors for cardiovascular diseases (8,(35)(36)(37). There are some differences between the major criteria for the clinical diagnosis of metabolic syndrome, but the latest guidelines (IDF/NHBLI/AHA/World Heart Federation/International Atherosclerosis Society/International Association for the Study of Obesity, 2009) propose the presence of ≥3 of the following 5 criteria: Increased waist circumference with population-specific and country-specific criteria (in Europid >94 cm for men or >80 cm for women), triglyceride level ≥1.7 mmol/l (≥150 mg/dl) or drug treatment, HDL cholesterol <1.0 mmol/l (<40 mg/dl) in men or <1.3 mmol/l (<50 mg/dl) in women or drug treatment, high blood pressure ≥130/85 mmHg or drug treatment and fasting plasma glucose ≥5.6 mmol/l (≥100 mg/dl) or drug treatment (8,19,22,38). Metabolic syndrome can be associated with moderate-to-severe psoriasis with a high prevalence (~50%), with patients with psoriasis (women more than men) having at least twice the risk of associating metabolic syndrome or individual components of the metabolic syndrome compared with patients without psoriasis (8,9,12,18,38).…”