Special Issue: “Skin Disease and Comorbidities”

Yamanaka, Keiichi

doi:10.3390/jcm10245754

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…Chronic dermatological conditions contribute to the burden of non-communicable diseases in the older adults [9][10][11][12]. A significant association has been demonstrated between chronic inflammatory skin diseases such as psoriasis, atopic dermatitis and immunobullous skin diseases and long standing systemic and psychiatric disorders including cardiovascular diseases, renal diseases, metabolic problems as well as extra-cutaneous malignancies [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

A Retrospective Review of Chronic Non-Communicable Dermatoses Among Older Adults at a Tertiary Healthcare Facility in Southwestern Nigeria

Ajani,

Olanrewaju,

Enitan

et al. 2023

Dermatol Pract Concept

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Introduction: Aging is a ubiquitous human trait that predisposes older persons to chronic diseases. Compared with systemic non-communicable diseases, a significant gap exists in literature on the burden of non-communicable dermatoses (NCDs) amongst older adults, particularly in low and middle-income countries. Objectives: The aim of this study was to document the epidemiology and clinical pattern of non-communicable skin diseases among older adults in Nigeria. Methods: We conducted a retrospective review of medical records of ambulant adults aged ≥60 years referred for dermatological care at a teaching hospital in Southwestern Nigeria between February 2017 and February 2022. The frequency and pattern of NCDS were recorded for descriptive statistical analysis using SPSS 20 statistics software. The level of statistical significance was set at 0.05. Result : A total of 553 medical records were reviewed with a female: male ratio of 1.3:1 The mean age of the study population was 68.85 ±7.87. Six out of every 10 patients (60.6%) had at least one chronic NCD. The incidence of chronic NCDs declined with increasing age. Chronic eczemas (22.4%), pigmentary dermatoses (9.4%), and skin tumors (8.7%) were the most frequent chronic non-communicable dermatoses recorded. Older males had a significantly higher incidence of chronic eczemas while chronic urticarias and skin tumors demonstrated significant female preponderance. Conclusion: There is a high burden of Chronic NCDs with significant gender disparities among older adults with skin problems in Nigeria. Pre-emptive planning and resource allocation towards specialist geriatric-dermatology services are needed to address the skin-health needs of the growing geriatric population.

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Section: Introductionmentioning

confidence: 99%

A Retrospective Review of Chronic Non-Communicable Dermatoses Among Older Adults at a Tertiary Healthcare Facility in Southwestern Nigeria

Ajani,

Olanrewaju,

Enitan

et al. 2023

Dermatol Pract Concept

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“…Interleukin (IL)-23 produced by various IL-23-producing cells induces IL-17 production from various IL-17-producing cells such as T-helper (Th)17, IL-17 producing CD8+ T cells (Tc17), and innate lymphoid cells type 3 (ILC3). IL-17 stimulates keratinocytes to produce inflammatory cytokines/chemokines, which further activate IL-23-producing cells and recruit IL-17producing cells and neutrophils(Yamanaka, 2021).…”

mentioning

confidence: 99%

Investigating the Impact of Secukinumab Bulk and Liposome Forms on Lymphocytes from Psoriasis Patients, as Compared to Healthy Controls, to Determine the Improvement in Bioavailability of Secukinumab Nanoliposomes

Layas,

Isreb,

Ghaderi

et al. 2024

Preprint

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Psoriasis is a multi-factorial immune-mediated disease that affects approximately 2% of the UK population and 2.5% worldwide. The condition can impact multiple organs, including the skin and joints. In moderate to severe cases, systemic and topical medications may not provide adequate relief, and as a result, biologic treatments are often administered as a monotherapy or in combination with other treatments. While biologic treatments are more effective than systemic and topical medications in treating psoriasis, patients require close supervision and monitoring while receiving this type of treatment. Liposomes are highly versatile and can be employed for therapy and research applications. They enhance drug retention at the site of administration, thereby reducing systemic side effects. Our study was the first to investigate the genotoxicity of secukinumab, an ideal biologic treatment for psoriasis (a human IgG1k antibody, anti-IL17A), in bulk and liposome nanoparticles on the lymphocytes of psoriasis patients compared to healthy individuals. We evaluated and com-pared the genotoxicity of secukinumab in bulk and liposomal form using the Comet and micronucleus assays. Both assays demonstrated that secukinumab in both forms did not ex-hibit genotoxicity and reduced DNA damage following treatment of the lymphocytes from healthy individuals and psoriatic patients with secukinumab bulk and liposomes format. Both concentrations of secukinumab used (2.1 and 2.8 µg/mL) effectively decreased H2O2-induced DNA damage in both groups to nearly the level of the negative control. Secukinumab bulk and liposome form significantly decreased H2O2-induced damage and efficiently attenuated its adverse effects both in the Comet (p<0.0001) and micronucleus assays (p<0.01). Overall, secukinumab in both forms exhibited protective and an-ti-genotoxic effects by demonstrating its potential to reduce DNA damage caused by oxida-tive stress and by not inducing any further damage in the lymphocytes of either healthy in-dividuals or patients.

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Special Issue: “Skin Disease and Comorbidities”

Abstract: The skin is one of the largest immune organs that involve innate and acquired immune systems, and is able to respond to internal and exogenous stimuli, producing a large amount of inflammatory cytokines, resulting in systemic inflammation [...]

Cited by 2 publications

References 18 publications

A Retrospective Review of Chronic Non-Communicable Dermatoses Among Older Adults at a Tertiary Healthcare Facility in Southwestern Nigeria

A Retrospective Review of Chronic Non-Communicable Dermatoses Among Older Adults at a Tertiary Healthcare Facility in Southwestern Nigeria

Investigating the Impact of Secukinumab Bulk and Liposome Forms on Lymphocytes from Psoriasis Patients, as Compared to Healthy Controls, to Determine the Improvement in Bioavailability of Secukinumab Nanoliposomes

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