Osteopontin: Relation between Adipose Tissue and Bone Homeostasis

Abstract

Osteopontin (OPN) is a multifunctional protein mainly associated with bone metabolism and remodeling. Besides its physiological functions, OPN is implicated in the pathogenesis of a variety of disease states, such as obesity and osteoporosis. Importantly, during the last decades obesity and osteoporosis have become among the main threats to health worldwide. Because OPN is a protein principally expressed in cells with multifaceted effects on bone morphogenesis and remodeling and because it seems to be one of the most overexpressed genes in the adipose tissue of the obese contributing to osteoporosis, this mini review will highlight recent insights about relation between adipose tissue and bone homeostasis.

Combination of biomarkers of vascular calcification and sTWEAK to predict cardiovascular events in chronic kidney disease

“…In addition, elevated serum OPG levels increased the risk of CVD and all-cause mortality in elderly women, and the association was more evident in women with poorer renal function (11). On the other hand, OPN belongs to the small integrin-binding ligand N-linked glycoprotein family (12). This protein is produced and secreted by different cell types such as macrophages, T cells, renal and vascular smooth muscle cells (VSMCs) as well as osteoblast and osteoclast (13).…”

RGD‐functionalized supported lipid bilayers modulate pre‐osteoblast adherence and promote osteogenic differentiation

“…The ECM protein osteopontin is expressed in bone, as well as in other organs, for example, kidney, heart, and inner ear (De Fusco et al, 2017;Denhardt & Guo, 1993). It is a signaling molecule that is upregulated in osteoblasts in response to mechanical loading (Young, Gerard-O'Riley, Kim, & Pavalko, 2009).…”

“…It is a signaling molecule that is upregulated in osteoblasts in response to mechanical loading (Young, Gerard-O'Riley, Kim, & Pavalko, 2009). Osteopontin is an essential protein in bone involved in matrix remodeling and tissue calcification (De Fusco et al, 2017). Thus, the higher OPN expression in preosteoblasts cultured on SLBs suggest that these cells were more osteogenic than on PLL-coated glass.…”

“…Cells on SLBs with 0.2 μM RGD showed increased OPN expression and a trend toward elevated RUNX2 expression compared to PLL.The ECM protein osteopontin is expressed in bone, as well as in other organs, for example, kidney, heart, and inner ear(De Fusco et al, 2017;Denhardt & Guo, 1993). Cells cultured on SLBs with and without RGD for 17 hr did express the osteogenic genes RUNX2, COL1a1, and OPN.…”

“…Cells cultured on SLBs with and without RGD for 17 hr did express the osteogenic genes RUNX2, COL1a1, and OPN. Osteopontin is an essential protein in bone involved in matrix remodeling and tissue calcification(De Fusco et al, 2017). It is a signaling molecule that is upregulated in osteoblasts in response to mechanical loading(Young, Gerard-O'Riley, Kim, & Pavalko, 2009).…”