Targeting the Role of PRME in Regulating Bone Remodelling During Postmenopausal Osteoporosis
Anish Rajamohanan Jalaja,
Aswathy Nair,
Vijayalakshmi Bindumadhavan
et al.
Abstract:Postmenopausal osteoporosis (PMO) is an old age disorder associated with estrogen deficiency, which reduces bone mass and makes bones more prone to fracture. The present study was proposed to evaluate the invivo osteogenic efficiency of Pterospermum rubiginosum methanolic bark extract (PRME) in the PMO model. Molecular docking studies on transcription factor NFATC1 showed excellent interactions with phytochemical ligands with the lowest binding energies. Female Sprague Dawley (SD) rats (n=24) were divided into… Show more
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