Osteopontin Reduces Biofi lm Formation in a Multi-Species Model of Dental Biofi lm

Connery, Amy K.; Peterson, Robin L.; Baker, David A.; Randolph, Christopher; Kirkwood, Michael W.

doi:10.1201/b16593-11

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…[5][6] Its use has increased over the last two decades in Western countries and a large number of investigations on its components and biological properties has been carried out. Therapeutic effects against different pathologies such as tumors [7][8][9][10] , heart diseases 1 , obesity 11 , diabetes 12 , liver ailments [13][14] , respiratory diseases 15 , inflammation [16][17] , viral [18][19] and bacterial infections [20][21] , caries and gingivitis [22][23][24] have been confirmed or recognized.…”

Section: Introductionmentioning

confidence: 99%

Components in Lentinus edodes mushroom with anti-biofilm activity directed against bacteria involved in caries and gingivitis

et al. 2018

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The present study investigated the compounds present in the low molecular mass fraction of Lentinus edodes mushroom (shiitake) extract and their anti-virulence activity against oral pathogens (reference and clinical Streptococcus mutans, Actinomyces naeslundii, and Prevotella intermedia strains). Oxalic, succinic, and quinic acids, and adenine, inosine, and uridine were identified by HPLC-DAD-ESI-MS/MS. Their anti-biofilm production and preformed biofilm disaggregation activities were studied using commercial standard compounds at different concentrations. As regards S. mutans, the highest activity was shown by adenine at 5 mg mL-1 both in the biofilm inhibition (BI 50%) and biofilm disaggregation tests (BD 20%). Considering A. naeslundii, BI values close to 80% were registered for oxalic acid at 1 mg mL-1 and 2 mg mL-1 and BD 50% for quinic acid at 3 mg mL-1. A weaker activity was found against P. intermedia. Furthermore, different mixtures of the commercial standards were tested showing that the activity of a compound can be strongly and sometimes negatively affected by the presence of the other compounds.

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Section: Introductionmentioning

confidence: 99%

Components in Lentinus edodes mushroom with anti-biofilm activity directed against bacteria involved in caries and gingivitis

et al. 2018

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“…The total bacterial numbers, as well as numbers of eight key taxa in the oral community, were investigated over time and results indicated that the shiitake extract lowered the numbers of some pathogenic taxa. [22]…”

Section: Introductionmentioning

confidence: 99%

The unexplored anticaries potential of shiitake mushroom

J¹,

Vinay²,

Jha³

et al. 2016

Phcog Rev

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Keeping an eye the escalating costs of dental services, the treatment cost of the consequences of dental caries can be reduced to manageable proportions by preventive measures aimed at decreasing the prevalence. One such measure is by increasing the consumption of caries preventive foods. Recently, there has been an upsurge of interest in mushrooms not only as a healthy food but also as a caries preventive food. The most common type of mushroom, Lentinula edodes also called as shiitake, is studied in-depth for its oral health benefits. The cultivation of shiitake dates way back to 1100 A.D. during the rule of Sung dynasty which is replaced by more modern and efficient sawdust substrate log cultures lately. Shiitake mushroom extract can be isolated in various forms such as freeze dried, oil, and ethyl acetate extracts. Various biologically active compounds such as erythritol, copalic acid, adenosine, carvacrol, and many more are responsible for this mushroom's antimicrobial activity. Anticariogenicity can be attributed to the induction of the detachment of cariogenic microorganisms from hydroxyapatite, changes in cell surface hydrophobicity, bactericidal activity, and disruption of signal transduction in Streptococcus mutans as proved through various in vivo and in vitro studies. Apart from these benefits, it has tremendous potential to be used as an antioxidant, anticancer, antigingivitis, antifungal, and antiviral agent. The one and only known adverse reaction due to shiitake mushroom consumption is the eruption of pruritic erythematous papules termed as shiitake dermatitis. This review highlights the unexplored anticaries potential of one such useful bioactive metabolite-shiitake mushroom.

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Osteopontin Reduces Biofi lm Formation in a Multi-Species Model of Dental Biofi lm

Cited by 2 publications

References 17 publications

Components in Lentinus edodes mushroom with anti-biofilm activity directed against bacteria involved in caries and gingivitis

Components in Lentinus edodes mushroom with anti-biofilm activity directed against bacteria involved in caries and gingivitis

The unexplored anticaries potential of shiitake mushroom

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