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With an acceptable safety profile, celecoxib combined with FOLFOX7 achieved RR and PFS in the lower range of that obtained with FOLFOX7 alone. These results indicate the lack of synergy between FOLFOX7 and celecoxib. PFS of 6 months appears lower than PFS obtained in OPTIMOX1 study with simplified LV5FU2 in maintenance therapy.

In the present work, AgNPs were prepared using a simple bio-reduction method. This is ecologically welcoming and cost-effective method. Yellow colored blooms concentrate of Argemone mexicana and Turnera ulmifolia are used as bio reducing agents in the study. The formation of silver nanoparticles was confirmed by UV-Vis spectrophotometer and characterization of the nanoparticles was done by FTIR, SEM, XRD and EDX. The Antibacterial action of silver nanoparticles was tested against Staphylococus aureus, Pseudomonas aeruginosa, Escherichia coli and Klebsiella aerogenes. The phytochemical analysis of the blooms concentrate has shown the existence of saponins, alkaloids, amino acids, phenols, tannins, terpenoids, flavonoids and cardiac glycosides. In vitro anti-oxidant action of both A. mexicana and T. ulmifolia AgNPs were studied by DPPH assay and reducing power assay.

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In the current study, we have built up a novel, green approach technique for the synthesis of silver nanoparticles (Ag NPs) from Rauvolfia tetraphylla leaves extract. The synthesized nanoparticles were thoroughly characterized using different analytical techniques like X-ray diffraction, Fourier transform infrared spectroscopy, UV-Vis spectroscopy (UV-Vis), scanning electron microscopy, energy-dispersive X-ray spectroscopy and transmission electron microscope analysis. It is confirmed as a cubic phase with average particle size about 40 nm with a spherical shape. Further, the characterized material was inspected for the photocatalytic degradation of most common environmental pollutants (carcinogenic organic dyes) like Methylene blue (M.B), Rhodamine B (Rh. B) and Rose bengal (R.B) with degradation efficiency of 81, 55 and 80% respectively. In addition, it was examined by optical property (photoluminescence) with blue emission by the excitation at 370 to 400 nm, which is useful for blue LEDs (light emitting diode). Furthermore, it also shows the superior anti-bacterial activity against gram-positive bacterias such as Pseudomonas aeruginosa, Escherichia coli and Klebsiella aerogenes and gram-negative bacteria Staphylococcus aureus. Ag NPs synthesized using Rauvolfia tetraphylla leaf extract exhibited a good photocatalytic and antibacterial activity. Hence, it's a first to report the synthesis of Ag NPs using natural reducing agent Rauvolfia tetraphylla leaf extract for Luminescence and Dye degradation applications.

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