Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas

Monteiro, Leonardo de Almeida; Salgado, Breno S.; Oliveira, Deílson Elgui de; Calderón, Luis Gabriel Rivera; Montoya-Flórez, Luis Mauricio; Sanctis, Paula de; Rocha, Noeme Sousa

doi:10.1590/1678-5150-pvb-6489

Cited by 2 publications

References 80 publications

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A single-cell transcriptomic study reveals immune suppressive cancer cell-immune cell interactions in the triple negative canine breast cancers

Kim,

Borcherding,

Song

et al. 2023

Preprint

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Clinical trials show promising outcomes for dogs with advanced solid tumors following treatment with immune checkpoint inhibitors (ICIs). Triple-negative breast cancer (TNBC) is very aggressive with very low response rates to ICIs. No study defines how canine TNBC interacts with the immune system within the tumor microenvironment, which is investigated in this study at the single cell level. Single cell RNA sequencing (scRNA-seq) datasets, including 6 groups of 30 dogs, were subject to integrated bioinformatic analysis. Immune modulatory TNBC subsets were identified by functional enrichment with immune-suppressive gene sets, including anti-inflammatory and M2-like macrophages. Key genes and immune-suppressive signaling pathways for TNBC included angiogenesis and leukocyte chemotaxis. Interactome analysis identified significant interactions between distinct subsets of cancer cells and effector T cells, suggesting T cell suppression. This is the first study to define immune-suppressive cancer cell subsets at the single-cell level, revealing potential mechanisms by which TNBC induces immune evasion in dogs.

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A single-cell transcriptomic study reveals immune suppressive cancer cell-immune cell interactions in the triple negative canine breast cancers

Kim,

Borcherding,

Song

et al. 2023

Preprint

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Is Osteopontin a Good Marker for Bone Metastasis in Canine Mammary Gland Tumor and Prostate Cancer?

Grisoni Sanchez,

Figueiredo,

de Sartori Camargo

et al. 2023

Animals

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Osteopontin (OPN) is a protein synthesized by a large number of cells, and its overexpression has been associated with the development and prognosis of cancer. OPN overexpression has been claimed to be a marker for the development of bone metastasis in human cancers, but no prior research has investigated the association between OPN expression and the metastasis of canine mammary gland tumors (MGTs) and prostate cancer (PC). Therefore, we investigated OPN expression in MGTs and PC samples from 50 canine patients with or without metastasis (bone vs. other sites). Higher OPN expression was detected in primary tumor samples from animals with bone metastasis than in those without bone involvement (p = 0.0321). In MGT samples, a significantly lower survival rate was observed in patients with higher OPN expression (p = 0.0171). In animals with PC, there was a strong trend toward lower survival in animals with positive OPN expression; however, this trend was not statistically significant (p = 0.0779). From these findings, it can be concluded that OPN may be a promising target for future MGTs and PC studies because of its role in enhancing cell invasion and metastasis.

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Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas

Cited by 2 publications

References 80 publications

A single-cell transcriptomic study reveals immune suppressive cancer cell-immune cell interactions in the triple negative canine breast cancers

A single-cell transcriptomic study reveals immune suppressive cancer cell-immune cell interactions in the triple negative canine breast cancers

Is Osteopontin a Good Marker for Bone Metastasis in Canine Mammary Gland Tumor and Prostate Cancer?

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