Osteopoikilosis: Pain as a Presenting Symptom in Three Family Members

Aghdashi, Mir Amir; Aghdashi, Mirmousa; Rabiepoor, Masumeh

doi:10.4137/cmamd.s7035

Cited by 14 publications

(15 citation statements)

References 12 publications

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“…The disease which usually develops asymptomatically is coincidentally diagnosed with direct radiographs [2]. The patients are generally asymptomatic, yet pain can be a rare symptom of the disease [3]. Characteristically, the disease is observed in direct radiographs as multiple oval and round densities have 2 -10 mm size on epiphyseal and metaphyseal regions on long bones [4].…”

Section: Discussionmentioning

confidence: 99%

Bone Pathology: Osteopoikilosis

Tolunay¹,

Arslan²,

Bingöl³

et al. 2013

OJO

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Osteopoikilosis is a rare benign sclerotic bone dysplasia. The disease which usually develops asymptomatically is coincidentally diagnosed with direct radiographs. Our subject, a 52-year-old male was admitted to our policlinic two days ago due to turning of his left ankle causing pain and swelling on his left ankle. We asked for bilateral direct radiograph of left ankle. The left ankle radiograph indicates multiple, small oval/round hyperdense sclerotic regions. As a result of available clinical finding and radiological viewing, the patient was diagnosed with osteopoikilosis.

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Section: Discussionmentioning

confidence: 99%

Bone Pathology: Osteopoikilosis

Tolunay¹,

Arslan²,

Bingöl³

et al. 2013

OJO

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“…Typically, there is no increased uptake of radiopharmaceutical substance on nuclear medicine bone scan in OPK [2,8] as was found in our patient. Although the risk of malignant transformation with OPK is very rare, osteosarcoma, giant cell tumors, and chondrosarcoma have been associated with OPK [1,11].…”

Section: Discussionmentioning

confidence: 99%

“…NSAIDs are often used as an option for the treatment of pain. Analgesics such as acetaminophen and opioids can also be used [2,11,13]. Rare active lesions have been treated with bisphosphonate therapy, but the results are controversial [12].…”

Section: Discussionmentioning

confidence: 99%

Osteopoikilosis: what does the rheumatologist must know about it?

et al. 2012

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Osteopoikilosis (OPK) is a rare, benign, and asymptomatic bone dysplasia that is developed during childhood and persists throughout life. This condition is generally found incidentally on plain radiographies made by other reasons. The main differential diagnosis is osteoblastic metastasis. So, OPK must be in differential diagnosis when bone lesions are identified on plain radiograph to avoid alarming the patient with more serious disease and misdiagnosis. In this paper, we review the clinical manifestation, pathophysiology, diagnosis, and treatment of OPK.

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“…OPK is benign, usually asymptomatic, and is discovered incidentally on radiographs but some cases described in the literature report an association with pain and joint effusions (15–20%), skin manifestations, bone or rheumatic diseases, organ anomalies, and endocrine dysfunctions [ 4 – 6 , 9 ]. More extensive radiological investigations make the diagnosis, by showing multiple sclerotic lesions symmetrical with a predilection for epiphyseal and metaphyseal regions of long bones [ 2 , 4 , 10 ]. The differential diagnosis includes other osteoblastic bone diseases, particularly bone metastases.…”

Section: Introductionmentioning

confidence: 99%

Traumatic Fracture in a Patient with Osteopoikilosis

Mortier

Docquier

2014

Case Reports in Orthopedics

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We report a case of traumatic humeral neck fracture occurring in a patient with osteopoikilosis after a motorcycle accident. The radiograph revealed the fracture but also multiple bone lesions. A few years before, the patient had been operated for a maldiagnosed chondrosarcoma of the humeral head. Osteopoikilosis is a rare benign hereditary bone disease, whose mode of inheritance is autosomal dominant. It is usually asymptomatic and discovered incidentally on radiograph that shows the presence of multiple osteoblastic lesions. It can mimic other bone pathologies, in particular osteoblastic metastases. Osteopoikilosis is a diagnosis that should be kept in mind to avoid misdiagnosis, particularly with regard to cancer metastasis. This disorder does not require any treatment and complications are rare. However, there may be associated anomalies that require follow-up.

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Osteopoikilosis: Pain as a Presenting Symptom in Three Family Members

Cited by 14 publications

References 12 publications

Bone Pathology: Osteopoikilosis

Bone Pathology: Osteopoikilosis

Osteopoikilosis: what does the rheumatologist must know about it?

Traumatic Fracture in a Patient with Osteopoikilosis

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