Osteonevus of Nanta: a case report in a combined melanocytic nevus

Melo, Elaine Dias; Couto, Patrícia Amaral; Schettini, Antônio Pedro Mendes; Rodrigues, Carlos Alberto Chirano

doi:10.1016/j.abd.2019.04.017

Cited by 4 publications

(5 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two primary hypotheses have been proposed: the presence of either bone metaplasia or a hamartomatous lesion. 3 With regards to the former hypothesis, repeated trauma, chronic inflammation, or even melanocytic proliferation are capable of inducing the differentiation of dermal fibroblasts into osteoblasts. 7 According to the second hypothesis, there are mesenchymal stem cells (capable of differentiating into osteocytes) present at aberrant sites that ultimately lead to the formation of a hamartoma with coexistence of cells from both mesodermal and ectodermal origins.…”

Section: Discussionmentioning

confidence: 99%

“…1 This condition was first described in an intradermal nevus by Heidingsfeld in 1908 and later named osteonevus of Nanta in 1911; since then, cases of osseous metaplasia occurring in blue and combined nevi have also been reported. 2 , 3 Osteonevus of Nanta is commonly diagnosed in adults, with most cases being reported in women between the fourth and the fifth decades of life. 4 Its precise incidence is not known, but it is considered a rare condition, with an estimated incidence of approximately 0.14% among pigmented skin lesions.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Osteonevus of Nanta in a 3-year-old child with dermatoscopic characterization

Tartaglia,

Ciolfi,

Sartor

et al. 2023

JAAD Case Reports

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Osteonevus of Nanta in a 3-year-old child with dermatoscopic characterization

Tartaglia,

Ciolfi,

Sartor

et al. 2023

JAAD Case Reports

View full text Add to dashboard Cite

“…In particular, keratin in hair or nails may be associated with ossifying lesions of melanocytic nevi, [26,27] ingrown nails, [28] and pyogenic granulomas [29,30] . In melanocytic nevus with aberrant ossification, a foreign body reaction occurs in response to damaged hair follicles or free hair shafts [26,27] . Reportedly, ossifying pyogenic granulomas often appear at or around the nail bed [29,30] .…”

Section: Discussionmentioning

confidence: 99%

“…[29,30] In melanocytic nevus with aberrant ossification, a foreign body reaction occurs in response to damaged hair follicles or free hair shafts. [26,27] Reportedly, ossifying pyogenic granulomas often appear at or around the nail bed. [29,30] Hence, the foreign body reactions observed in these lesions are considered to be associated with nail keratin.…”

Section: Discussionmentioning

confidence: 99%

Ossifying pilomatricoma and a novel hypothesis for its pathogenesis

et al. 2022

View full text Add to dashboard Cite

Rationale:Pilomatricoma is a benign skin appendageal tumor derived from hair follicle matrix cells that commonly affects the head, neck, and upper extremities of the pediatric population. Since the original tumor description, diverse variants have been reported in the literature. Pilomatricoma with florid osseous metaplasia is described as an ossifying pilomatricoma and is recognized as a distinct variant of this benign tumor. However, the pathogenesis of this variant remains unclear. In this study, we present an uncommon case of ossifying pilomatricoma and address the pathogenesis of metaplastic ossification through a comprehensive literature review.Patient concerns:A 14-year-old boy presented with an asymptomatic protuberant mass in the preauricular region.Diagnosis:Based on its clinicopathological features, we diagnosed the lesion as an ossifying pilomatricoma.Interventions and outcomes:The lesion was surgically removed under local anesthesia. The postoperative course was uneventful during the 6-month postoperative follow-up.Lessons:We suggest that metaplastic ossification in ossifying pilomatricoma represents another feature of foreign body reaction to keratinous materials containing shadow cells in old lesions and a walling-off phenomenon to prevent exposure of surrounding tissues to keratinous materials.

show abstract

“…In some cases, as in ours, adipocytes may be present. Mononuclear infiltrate, foreign body granuloma or mixed granulomas are frequent findings 6 …”

Section: Discussionmentioning

confidence: 99%