Osteomielite pelo Paracoccidioides brasiliensis

Lambertucci, José Roberto; Botelho, Jean Sávio; Melo, Frederico Henrique Corrêa de

doi:10.1590/s0037-86822002000300015

Cited by 5 publications

(3 citation statements)

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“…Other radiological findings, described in 19 cases of osteoarticular PCM as osteolytic lesions and marginal sclerosis, as described by MONSIGNORE et al. 25 , bone flattening 15 irregularities of the trabecular bone 23 , joint swelling and the destruction of articular cartilage, which were indistinguishable from other infectious processes 10 , were also present among our findings.…”

Section: Discussionsupporting

confidence: 86%

DOSE RESPONSE EFFECT OF Paracoccidioides brasiliensis IN AN EXPERIMENTAL MODEL OF ARTHRITIS

Loth

Biazim

Santos

et al. 2014

Rev. Inst. Med. trop. S. Paulo

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Paracoccidioidomycosis (PCM) is caused by the dimorphic fungus Paracoccidioides brasiliensis (Pb) and corresponds to prevalent systemic mycosis in Latin America. The aim of the present work was to evaluate the dose response effect of the fungal yeast phase for the standardization of an experimental model of septic arthritis. The experiments were performed with groups of 14 rats that received doses of 103, 104 or 105 P. brasiliensis (Pb18) cells. The fungi were injected in 50 µL of phosphate-buffered saline (PBS) directly into the knee joints of the animals. The following parameters were analyzed in this work: the formation of swelling in knees infused with yeast cells and the radiological and anatomopathological alterations, besides antibody titer by ELISA. After 15 days of infection, signs of inflammation were evident. At 45 days, some features of damage and necrosis were observed in the articular cartilage. The systemic dissemination of the fungus was observed in 11% of the inoculated animals, and it was concluded that the experimental model is able to mimic articular PCM in humans and that the dose of 105 yeast cells can be used as standard in this model.

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Section: Discussionsupporting

confidence: 86%

DOSE RESPONSE EFFECT OF Paracoccidioides brasiliensis IN AN EXPERIMENTAL MODEL OF ARTHRITIS

Loth

Biazim

Santos

et al. 2014

Rev. Inst. Med. trop. S. Paulo

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“…(Table 1). [1][2][3]8,[10][11][12] Bones that are most affected by the disease are those of the chest wall, 7 including ribs, sternum, scapula, and acromion. This finding may be explained by the common routine of performing a chest radiography when paracoccidioidomycosis is suspected.…”

Section: Discussionmentioning

confidence: 99%

Unifocal Bone Paracoccidioidomycosis, Brazil

Correa-de-Castro

Pompílio²,

Odashiro³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. We report a 47 year-old man from the State of Mato Grosso do Sul, Brazil, with unifocal tibial paracoccidioidomycosis. A radiograph showed an osteolytic lesion on the tibial middle third diaphysis. The diagnosis was confirmed by histopathologic analysis, and treatment with sulfamethoxazole and trimethoprim was started. After three months, the patient showed significant clinical improvement. Ten months after treatment, the patient showed lesion bone healing. This case describes the rare occurrence of an osteolytic lesion caused by endemic Paracoccidioides brasiliensis in Latin America.

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“…Our patient also had pleural involvement with peripleuritis and subcutaneous abscesses on the chest wall with costal and sternal osteomyelitis. Bone involvement has been frequently described in the disease 5,10,15 , although there is no reference to the involvement of the endothoracic fascia with peripleuritis. This clinical finding implies the involvement of pleuroparietal lymph nodes with peripleural abscesses, some of which rupture through weak points in the chest wall.…”

Section: Discussionmentioning

confidence: 99%

Disseminated paracoccidioidomycosis with peripleuritis in an AIDS patient

Corti

Villafañe

Negroni

et al. 2004

Rev. Inst. Med. trop. S. Paulo

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SUMMARYParacoccidioidomycosis is one of the most frequent systemic and endemic mycoses of Latin America caused by a dimorphic fungus. In AIDS patients, paracoccidioidomycosis appears as a severe and disseminated disease with a wide spectrum of clinical findings. The CD4 counts are usually less than 200 cell/µL. We present a case of disseminated paracoccidioidomycosis with peripleuritis and subcutaneous abscesses on the chest wall as initial manifestation of AIDS. In endemic countries, paracoccidioidomycosis should be included as an opportunistic infection in AIDS.

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Osteomielite pelo Paracoccidioides brasiliensis

Cited by 5 publications

References 0 publications

DOSE RESPONSE EFFECT OF Paracoccidioides brasiliensis IN AN EXPERIMENTAL MODEL OF ARTHRITIS

DOSE RESPONSE EFFECT OF Paracoccidioides brasiliensis IN AN EXPERIMENTAL MODEL OF ARTHRITIS

Unifocal Bone Paracoccidioidomycosis, Brazil

Disseminated paracoccidioidomycosis with peripleuritis in an AIDS patient

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