Osteolytic Indicators Found in Total Knee Arthroplasty Synovial Fluid Aspirates

Kovacik, M.W.; Gradisar, Ivan A.; Haprian, J.J.; Alexander, Thomas S.

doi:10.1097/00003086-200010000-00022

Cited by 27 publications

(20 citation statements)

References 19 publications

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“…At the same time, plasma levels of TNF-α were significantly higher in patients with cemented prostheses than those with cementless varieties. These results suggest that cement promoted the release of proinflammatory cytokines such as TNF-α both locally and systematically, leading to prosthetic osteolysis in total hip arthroplasty [29]. But the postoperative years of cemented THA was significantly longer than that of cementless hips in this study, so further study including more samples to confirm the conclusion is needed.…”

Section: Discussionmentioning

confidence: 66%

Multiple biomarkers analysis for the early detection of prosthetic aseptic loosening of hip arthroplasty

Huang

et al. 2013

International Orthopaedics (SICOT)

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Section: Discussionmentioning

confidence: 66%

Multiple biomarkers analysis for the early detection of prosthetic aseptic loosening of hip arthroplasty

Huang

et al. 2013

International Orthopaedics (SICOT)

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“…The most comprehensive of these studies of retrieved implants reported a 20-fold increase in the number of osteoclasts on bone surfaces surrounding loose implants compared with bones surrounding well-fixed implants [3 I]. In addition, synovial fluid of patients with loose implants contains elevated levels of TRAP, presumably due to secretion of this enzyme by the increased number of osteoclasts [33,38]. Although the increase in the number of osteoclasts is consistent with the hypothesis that increased osteoclast differentiation is increased during implant loosening, these in vivo studies are not able to distinguish between increased osteoclast differentiation and increased osteoclast survival.…”

Section: Differentiation Of Precursors Into Mature Osteoclastsmentioning

confidence: 99%

The role of osteoclast differentiation in aseptic loosening

Greenfield

Ragab

et al. 2002

Journal Orthopaedic Research

106

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The major cause of orthopaedic implant loosening is thought to be accelerated osteoclastic bone resorption due to the action of cytokines produced in response to phagocytosis of implant-derived wear particles. This accelerated osteoclastic bone resorption could be due to increases in any of the following processes: recruitment of osteoclast precursors to the local microeiivironment, differentiation of precursors into mature multinucleated osteoclasts, activation of mature osteoclasts, and/or survival of osteoclasts. Our studies have focused on differentiation and survival to complement work by others who have focused on recruitment of precursors and activation. Taken together, our studies and those of other investigators provide strong evidence that increased recruitment of osteoclast precursors and their subsequent differentiation play major roles in wear particle-induced osteolysis. In contrast, increased osteoclast activation and survival appear to play minor roles. These studies suggest that development of therapeutic interventions that reduce either recruitment or differentiation of osteoclast precursors would improve the performance of orthopaedic implants.

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“…9,13 Our current and ongoing studies are aimed at determining whether spectroscopic methods can be used to answer some of the open questions in the biomedical community concerning the biocompatibility of prosthetic metal alloys 15 and the nature of prosthetic failure. 16,17 In this study, we use x-ray photoelectron spectroscopy (XPS) and Raman microscopy to identify the nature of wear particles. Knee synovial fluid was aspirated from different prosthetics patients and centrifuged, resulting in small wear deposits resembling flakes or pellets.…”

Section: Introductionmentioning

confidence: 99%

Surface analysis of prosthetic wear debris

Tokash

Stojilović

Ramsier

et al. 2005

Surface & Interface Analysis

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Total knee arthroplasty introduces foreign materials into the body that are intended to withstand significant biological and mechanical stresses while maintaining biocompatibility. Unfortunately many arthroplasty patients experience inflammation and pain, presumably due to wear debris that dislodges from the artificial joint over time. The failure mechanisms of prosthetic devices and the chemical make-up of the associated wear debris are presently unclear. In this study, we use x-ray photoelectron spectroscopy and Raman microscopy to identify the chemical composition of the wear debris. Knee synovial fluid was aspirated from seven different prosthetics patients and centrifuged, resulting in small deposits of wear debris. Our analysis identifies oxidized titanium in five of the seven sets of samples, indicating femoral component wear and potentially back-side wear of the tibial base plates of the prosthetics. Furthermore, samples with large percentages of titanium also contain sodium, whereas the others contain chlorine. This may indicate differences in the chemical composition of synovial fluid under different inflammatory conditions.

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Osteolytic Indicators Found in Total Knee Arthroplasty Synovial Fluid Aspirates

Cited by 27 publications

References 19 publications

Multiple biomarkers analysis for the early detection of prosthetic aseptic loosening of hip arthroplasty

Multiple biomarkers analysis for the early detection of prosthetic aseptic loosening of hip arthroplasty

The role of osteoclast differentiation in aseptic loosening

Surface analysis of prosthetic wear debris

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