Osteointegration of femoral stem prostheses with a bilayered calcium phosphate coating

Goyenvalle, Eric; Aguado, Eric; Nguyen, Jean–Michel; Passuti, N; Guéhennec, Laurent Le; Layrolle, Pierre; Daculsi, Guy

doi:10.1016/j.biomaterials.2005.07.039

Cited by 44 publications

(24 citation statements)

References 65 publications

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“…However, mortality after surgery due to pulmonary embolism, pneumonia, heart infarct or thrombosis is not a common complication reported in dogs. The use of porous-coated cementless prosthesis has been reported elsewhere (Chen et al, 1983;DeYoung et al, 1992;Marcellin-Little et al, 1999;Goyenvalle et al, 2006), nonetheless we did not find any report describing interlocking stems in association with bioactive coating in dogs. The Zurich total hip replacement model is a locked prosthesis intended for use in small animals, its rate of complications was reported around 11% (Hummel et al, 2010).…”

Section: Discussioncontrasting

confidence: 46%

“…In biologic fixation the implant is coated with porous material leading to osseous growth inside the pore. In bioactive fixation, a bioactive material (hydroxyapatite, bioglass) is deposited onto prosthesis surface inducing osseous formation (Jasty et al, 1997;Fenollosa et al, 2000;Goyenvalle et al, 2006). Fixation with polymethylmethacrylate (PMMA) cement is the most used in canine hip prostheses and it offers immediate stability to the implant (Massat, 1995;Schulz, 2000).…”

Section: Introductionmentioning

confidence: 99%

“…Structural modifications such as stem roughening surface, stem precoating with PMMA or bioceramics, and surgical technique alterations such as pulsating washing of femoral cavity, rigorous osseous hemostasia, drying of medullar cavity and insertion of the stem in a pressing way into the femur have been proposed (Schulz, 2000;Goyenvalle et al, 2006). In humans, bioactive coating of the implants (biologic fixation) is usually performed; requiring approximately twelve weeks for complete weight bearing of the limb (Park et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

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Modified cementless total coxofemoral prosthesis: development, implantation and clinical evaluation

Arias

Blanco²,

Doretto

et al. 2013

Arq. Bras. Med. Vet. Zootec.

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The aim of this study was to modify canine coxofemoral prostheses and the clinical evaluation of the implantation. Fifteen canine hips and femora of cadavers were used in order to study the surface points of modification in prostheses and develop a perforation guide. Femoral stems and acetabular components were perforated and coated with biphasic calcium phosphate layer. Twelve young adult male mongrel dogs were implanted with coxofemoral prostheses. Six were operated upon and implanted with cemented canine modular hip prostheses, establishing the control group. The remaining six were implanted with a novel design of cementless porous tricalcic phosphate-hydroxyapatite coated hip prostheses. Clinical and orthopedic performance, complications, and thigh muscular hypotrophy were assessed up to the 120 th post-operatory day. After 120 days, animals with cementless prostheses had similar clinical and orthopedic performance compared to the cemented group despite the increased pain thigh hypotrophy. Animals that underwent cementless hip prosthesis evidenced more pain, compared to animals with cemented hip prosthesis that required longer recuperation time. No luxations, two fractures and two isquiatic neurapraxies were identified in the course of the study.

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Section: Discussioncontrasting

confidence: 46%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Modified cementless total coxofemoral prosthesis: development, implantation and clinical evaluation

Arias

Blanco²,

Doretto

et al. 2013

Arq. Bras. Med. Vet. Zootec.

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“…It is generally reported in the literature that ceramic coatings improve the osseointegration of metallic scaffolds by promoting the filling of gaps between bone and implant 12 , enhancing bone contact with the implant surface 11,28 and possessing osteoinductive properties 29,30 . However, the results of experimental studies comparing titanium implants with and without ceramic coatings have conflicting results, with evidence either of lack of benefit [31][32][33][34][35] or superior results 11,12,28,36 with bone growth acceleration 37 .…”

Section: Discussionmentioning

confidence: 99%

“…However, the results of experimental studies comparing titanium implants with and without ceramic coatings have conflicting results, with evidence either of lack of benefit [31][32][33][34][35] or superior results 11,12,28,36 with bone growth acceleration 37 . Taking together the results of push-out tests and SEM images observations, it was not possible to demonstrate a benefit of the β-TCP coating.…”

Section: Discussionmentioning

confidence: 99%

Paired evaluation of calvarial reconstruction with prototyped titanium implants with and without ceramic coating

et al. 2014

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PURPOSE:To investigate the osseointegration properties of prototyped implants with tridimensionally interconnected pores made of the Ti 6 Al 4 V alloy and the influence of a thin calcium phosphate coating. METHODS:Bilateral critical size calvarial defects were created in thirty Wistar rats and filled with coated and uncoated implants in a randomized fashion. The animals were kept for 15, 45 and 90 days. Implant mechanical integration was evaluated with a push-out test.Bone-implant interface was analyzed using scanning electron microscopy. RESULTS:The maximum force to produce initial displacement of the implants increased during the study period, reaching values around 100N for both types of implants. Intimate contact between bone and implant was present, with progressive bone growth into the pores. No significant differences were seen between coated and uncoated implants. CONCLUSION:Adequate osseointegration can be achieved in calvarial reconstructions using prototyped Ti 6 Al 4 V Implants with the described characteristics of surface and porosity.

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Comparative in vivo evaluation of porous and dense duplex titanium and hydroxyapatite coating with high roughnesses in different implantation environments

Borsari

Fini

Giavaresi

et al. 2008

J Biomedical Materials Res

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Ti (PG60) and Ti plus HA (HPG60) dense coatings with ultrahigh roughness (Ra: 74 +/- 8 microm and 53 +/- 18 microm, respectively) were compared to high Ti (Ti60) and Ti plus HA (HT60) high roughened porous coatings (Ra: 40 +/- 7 microm and 36 +/- 3 microm, respectively). Surfaces were implanted in cortical and trabecular bone of young adult (YOUNG), aged (AGED) and estrogen-deficient sheep (OVX) and analyzed by means of histology, histomorphometry and push-out tests 3 months after implantation. A significantly lower value in affinity index (AI) of PG60 when compared to TI60 (p < 0.01) was observed in cortical bone. In trabecular bone, lower values in AI were found in TI60 and PG60 when compared to their HA-coated surfaces (p < 0.0005). Bone ingrowth (BI) of TI60 and PG60 was significantly lower than that of the HA-coated surfaces in trabecular bone (p < 0.05). Significantly lower values in BI in OVX sheep in comparison to YOUNG sheep in both cortical and trabecular bone were observed (p < 0.05). Data showed that high roughness and Ti and HA-coated surfaces are suitable for aged and osteoporotic patients. HA coatings represent the most successful strategy in trabecular bone.

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Osteointegration of femoral stem prostheses with a bilayered calcium phosphate coating

Cited by 44 publications

References 65 publications

Modified cementless total coxofemoral prosthesis: development, implantation and clinical evaluation

Modified cementless total coxofemoral prosthesis: development, implantation and clinical evaluation

Paired evaluation of calvarial reconstruction with prototyped titanium implants with and without ceramic coating

Comparative in vivo evaluation of porous and dense duplex titanium and hydroxyapatite coating with high roughnesses in different implantation environments

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