Comparative in vivo evaluation of porous and dense duplex titanium and hydroxyapatite coating with high roughnesses in different implantation environments

Abstract

Ti (PG60) and Ti plus HA (HPG60) dense coatings with ultrahigh roughness (Ra: 74 +/- 8 microm and 53 +/- 18 microm, respectively) were compared to high Ti (Ti60) and Ti plus HA (HT60) high roughened porous coatings (Ra: 40 +/- 7 microm and 36 +/- 3 microm, respectively). Surfaces were implanted in cortical and trabecular bone of young adult (YOUNG), aged (AGED) and estrogen-deficient sheep (OVX) and analyzed by means of histology, histomorphometry and push-out tests 3 months after implantation. A significantly lower value in affinity index (AI) of PG60 when compared to TI60 (p < 0.01) was observed in cortical bone. In trabecular bone, lower values in AI were found in TI60 and PG60 when compared to their HA-coated surfaces (p < 0.0005). Bone ingrowth (BI) of TI60 and PG60 was significantly lower than that of the HA-coated surfaces in trabecular bone (p < 0.05). Significantly lower values in BI in OVX sheep in comparison to YOUNG sheep in both cortical and trabecular bone were observed (p < 0.05). Data showed that high roughness and Ti and HA-coated surfaces are suitable for aged and osteoporotic patients. HA coatings represent the most successful strategy in trabecular bone.

Adjustment of the antibacterial activity and biocompatibility of hydroxypropyltrimethyl ammonium chloride chitosan by varying the degree of substitution of quaternary ammonium

“…The osteointegration of orthopaedic implants is very important to the functional reconstruction of the damaged tissue (Borsari et al, 2009;Landor et al, 2007). Because of this, the implant surface needs to have low cytotoxicity and good biocompatibility with bone cells.…”

Development of a versatile procedure for the biofunctionalization of Ti-6Al-4V implants

“…Consequently, various surface modification procedures such as deposition of calcium phosphates [9], acid etching [10], plasma spraying [11] and alkaline treatment [12] were proposed to monitor interaction between the material and the organism and to improve the osseointegration of Ti alloys.…”

Prospects of Using Titanium Implants With Predetermined Osteogenic Properties

“…Вишневский и др. Перспективы применения титановых имплантатов с заданными остеогенными свойствами (нанокристаллическим гидроксиапа-титом, флуоридом, метафосфатом или октафосфатом кальция) их по-верхностей [1, 6, 10, 12, 28,34,55].…”