Osteoinduction of porous Ti implants with a channel structure fabricated by selective laser melting

Fukuda, A.; Takemoto, Mitsuru; Saito, Toshihiko; Fujibayashi, Shunsuke; Neo, Masashi; Pattanayak, Deepak K.; Matsushita, Tomiharu; Sasaki, Kiyoyuki; Nishida, N.; Kokubo, Tadashi; Nakamura, Takashi

doi:10.1016/j.actbio.2011.01.037

Cited by 288 publications

(172 citation statements)

References 38 publications

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“…The novel dithio-octonoate monomers exhibit high TBS to all metal adhesives tested after 2000 thermal cycles. These experimental results verified the excellent bondability of these new dithio -octonoate monomers to precious metals and alloys [30][31][32][33][34]. Comparison between dithio-octonoate monomers and sulfur-containing monomers in combination with precious metals and their alloys.…”

Section: Dithio-octonoate Monomers For Adhesion To Precious Metals Ansupporting

confidence: 61%

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Is the Ditio-Octonoate Monomer the Ideal for Adhesion to Precious Metals and their Alloys?

Estrada

2017

IJRRT

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A descriptive bibliographic review of the evidence provided in indexed articles and other bibliographic sources, such as books, theses and others, has been made. These were analyzed and after checking whether or not they met the inclusion/exclusion criteria of this work, finally were 27 articles of bibliographic review published in a hairpin that goes from 2007 to 2016. IntroductionThe use of metals in dentistry has great therapeutic advantages in many fields of dentistry, such as orthodontics, prostheses, conservative dentistry since its origins and more recently implantology [2]. Likewise, metals can be used on numerous and varied substrates: enamel, dentin, ceramics, resins or other metals [1]. Examples of adhesion of enamel or dentin to metals, orthodontic bands and brackets, or Maryland type adhesive bridges. It may be necessary to attach a metal to ceramics in the case of a metal crown, which by aesthetics will be covered or another metal (such as a cast post) to the metal of the crown and / or ceramics thereof, or even when it is free of metal [4].The first and foremost objective of dental adhesives is the long-lasting attachment to their substrates or adhesives, whether hard dental tissues or a wide range of materials (some new and others already contaminated when already in the mouth). The adhesive system, already discovered by Bouncoure and Bowen in the 1960s, has meant an improvement in speed, efficiency and convenience by simplifying the joining steps of two bodies of disparate origin and nature and reducing the time in the clinician's working time. The current trend in the development of dental adhesive systems follows the line of self-etch adhesives, multipurpose primers or adhesives that give a strong and durable adhesion indiscriminately to a multitude of adherents that coexist in the oral environment, ranging from tejdios (Enamel and dentin), precious metals (noble), alloys of precious metals and alloys of non-precious metals to dental porcelain, ceramics based on aluminum oxide (alumina) and zirconium-based ceramics [6,7].Do not overlook the many detractors of self-etch adhesives. On the one hand self-etching adhesives are easy to use and less prone to cause postoperative sensitivity. Although on the other hand, AbstractThe use of metals in dentistry presupposes the need for mechanisms of retention or adhesion of the same to different substrates; Such as enamel, dentin, ceramics, old resins and other metals [1].Throughout history these mechanisms have been changing and evolving, from the purely mechanical retention to the present mechanisms of adhesion [2,3]. It is in the decade of the 70 when they begin to develop adhesion materials. Prior to this, retention was basically mechanical, having also evolved from macromechanical retention systems to micromechanical retention systems [3]. It is at the end of the 70 when the first generation of adhesives appears; These monomers were 4-META (4-methacryloyloxyethyl trimellitate anhydride) and 10-MDP (10-methacryloyloxydecyl dihydrogen phosphate). Thes...

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Section: Dithio-octonoate Monomers For Adhesion To Precious Metals Ansupporting

confidence: 61%

“…Primers containing these sulfur-containing monomers have two very desirable advantages: simple application procedure and favorable adhesion result. The latter advantages are derived from the ability of sulfurcontaining monomers to form chemical bonds with metal atoms on the surfaces of precious metals [29,30].…”

Section: Discussionmentioning

confidence: 99%

Is the Ditio-Octonoate Monomer the Ideal for Adhesion to Precious Metals and their Alloys?

Estrada

2017

IJRRT

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“…Furthermore, this scaffold has a varying pore size ranging from 1330 µm on the outside to 940 µm at the core. These values have been previously reported to be favorable for cell colonization as well as bone ingrowth and vascularization [66][67][68].…”

Section: Discussionmentioning

confidence: 83%

Mechanical Properties and In Vitro Behavior of Additively Manufactured and Functionally Graded Ti6Al4V Porous Scaffolds

Onal

Frith

Jurg

et al. 2018

Metals

115

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Abstract:Functionally graded lattice structures produced by additive manufacturing are promising for bone tissue engineering. Spatial variations in their porosity are reported to vary the stiffness and make it comparable to cortical or trabecular bone. However, the interplay between the mechanical properties and biological response of functionally graded lattices is less clear. Here we show that by designing continuous gradient structures and studying their mechanical and biological properties simultaneously, orthopedic implant design can be improved and guidelines can be established. Our continuous gradient structures were generated by gradually changing the strut diameter of a body centered cubic (BCC) unit cell. This approach enables a smooth transition between unit cell layers and minimizes the effect of stress discontinuity within the scaffold. Scaffolds were fabricated using selective laser melting (SLM) and underwent mechanical and in vitro biological testing. Our results indicate that optimal gradient structures should possess small pores in their core (~900 µm) to increase their mechanical strength whilst large pores (~1100 µm) should be utilized in their outer surface to enhance cell penetration and proliferation. We suggest this approach could be widely used in the design of orthopedic implants to maximize both the mechanical and biological properties of the implant.

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“…Selective laser melting (SLM) is an AM technology that may be used to manufacture metal components [22], [23], [24] and [25]. During this process, a focused laser beam is used to selectively heat a bed of metallic powder above the materials melting point causing the particles to melt and fuse together.…”

mentioning

confidence: 99%

Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants

Cox

Jamshidi

Eisenstein

et al. 2016

Materials Science and Engineering: C

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Additive manufacturing technologies have been utilised in healthcare to create patient-specific implants. This study demonstrates the potential to add new implant functionality by further exploiting the design flexibility of these technologies. Selective laser melting was used to manufacture titanium-based (Ti-6Al-4V) implants containing a reservoir. Pore channels, connecting the implant surface to the reservoir, were incorporated to facilitate antibiotic delivery. An injectable brushite, calciumphosphate cement, was formulated as a carrier vehicle for gentamicin. Incorporation of the antibiotic significantly (p=0.01) improved the compressive strength (5.8± 0.7 MPa) of the cement compared to non-antibiotic samples. The controlled release of gentamicin sulphate from the calcium phosphate cement injected into the implant reservoir was demonstrated in short term elution studies using ultraviolet visible spectroscopy. Orientation of the implant pore channels were shown, using micro-computed tomography, to impact design reproducibility and the back-pressure generated during cement injection which ultimately altered porosity. The amount of antibiotic released from all implant designs over a 6 hour period (b28% of the total amount) were found to exceed the minimum inhibitory concentrations of Staphylococcus aureus (16 μg/mL) and Staphylococcus epidermidis (1 μg/mL); two bacterial species commonly associated with periprosthetic infections. Antibacterial efficacy was confirmed against both bacterial cultures using an agar diffusion assay. Interestingly, pore channel orientation was shown to influence the directionality of inhibition zones. Promisingly, this work demonstrates the potential to additively manufacture a titanium-based antibiotic eluting implant, which is an attractive alternative to current treatment strategies of periprosthetic infections.

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Osteoinduction of porous Ti implants with a channel structure fabricated by selective laser melting

Cited by 288 publications

References 38 publications

Is the Ditio-Octonoate Monomer the Ideal for Adhesion to Precious Metals and their Alloys?

Is the Ditio-Octonoate Monomer the Ideal for Adhesion to Precious Metals and their Alloys?

Mechanical Properties and In Vitro Behavior of Additively Manufactured and Functionally Graded Ti6Al4V Porous Scaffolds

Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants

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