Osteogenic sarcoma: noninvasive in vivo assessment of tumor necrosis with diffusion-weighted MR imaging.

Lang, Philipp; Wendland, Michael F.; Saeed, M.; Gindele, A; Rosenau, Werner; Mathur, Ashwini; Gooding, Charles A.; Genant, H K

doi:10.1148/radiology.206.1.9423677

Cited by 180 publications

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“…The signal intensity of DWI and the ADC values of the tissue change corresponding to the microstructure characteristics and physiological state of the tissues; these signal intensities have been used in various organs, including musculoskeletal tumors, and many studies have demonstrated the potential for providing information that can contribute to the differentiation between benign and malignant tumors (12)(13)(14)(15)(16). The most important component of signal attenuation on DWI in tumor tissues is the diffusion of water molecules in the extracellular spaces (12).…”

Section: Discussionmentioning

confidence: 99%

“…Diffusion-weighted MR imaging (DWI) is another method of assessing the functional properties of pathologic tissues and is useful for differentiation between benign and malignant tumors in various fields (8 -11), including the musculoskeletal system (12)(13)(14)(15)(16). DWI permits the quantitative assessment of water diffusion in tissues and therefore is used to measure the apparent diffusion coefficient (ADC), which reflects the mobility of water molecules in the tissues.…”

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confidence: 99%

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Characterization of chondroblastic osteosarcoma: Gadolinium‐enhanced versus diffusion‐weighted MR imaging

Yakushiji

Oka

Sato

et al. 2009

Magnetic Resonance Imaging

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Purpose: To detect differences in magnetic resonance imaging (MRI) between chondroblastic osteosarcoma and the other types of osteosarcomas or chondrosarcomas using gadolinium-enhanced versus diffusion-weighted sequences. Materials and Methods:Contrast-enhanced MRI and diffusion-weighted imaging (DWI) were performed in five chondroblastic osteosarcoma (CO) cases, 17 other types of osteosarcomas (OS), and 18 chondrosarcomas (CS). DWI was obtained with a single-shot echo-planar imaging (EPI) sequence using a 1.5T MR imager. The apparent diffusion coefficients (ADCs) of the minimum and maximum values were also obtained. The contrast-enhancement pattern was evaluated and minimum-maximum ADC value of CO was compared with other types of OS and CS.Results: Both CO and CS showed a similar enhancement pattern; both showed septonodular and peripheral rim enhancement. The minimum ADC value of CO (1.24 Ϯ 0.10 ϫ 10 Ϫ3 mm 2 /sec) was significantly higher than that of other types of OS (0.84 Ϯ 0.15 ϫ 10 Ϫ3 mm 2 /sec) and was significantly lower than that of CS (1.64 Ϯ 0.20 ϫ 10 Ϫ3 mm 2 /sec). In addition, the maximum ADC value of CO (2.28 Ϯ 0.20 ϫ 10 Ϫ3 mm 2 /sec) was significantly higher than that of other types of OS (1.33 Ϯ 0.26 ϫ 10 Ϫ3 mm 2 /sec).Conclusion: DWI appears to be more useful for differentiating between chondroblastic osteosarcoma and chondrosarcoma or other types of osteosarcoma than Gd-enhanced MRI.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Characterization of chondroblastic osteosarcoma: Gadolinium‐enhanced versus diffusion‐weighted MR imaging

Yakushiji

Oka

Sato

et al. 2009

Magnetic Resonance Imaging

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“…22,23 It is noteworthy that pathologic responses without any decrease in size were reported even in patients with solid tumors who received cytotoxic chemotherapy. Patients with myxoid liposarcoma who received trabectedin 24,25 and patients with osteosarcoma who received chemotherapy [26][27][28] are examples among sarcomas. We previously demonstrated that Choi criteria adapted to magnetic resonance imaging (MRI) correlated better with pathologic tumor response than RECIST in a series of 38 patients with high-grade soft tissue sarcomas who received preoperative chemotherapy with or without radiation therapy within a prospective phase 3 Italian Sarcoma Group/Spanish Sarcoma Group trial.…”

Section: Introductionmentioning

confidence: 99%

Tumor response assessment by modified Choi criteria in localized high‐risk soft tissue sarcoma treated with chemotherapy

Stacchiotti

Verderio²,

Messina

et al. 2012

Cancer

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BACKGROUND. The objective of this study was to compare the prognostic relevance of Response Evaluation Criteria in Solid Tumors (RECIST) versus Choi criteria for the assessment of response in patients with high-risk soft tissue sarcoma of the extremities or trunk wall who received preoperative chemotherapy with or without radiotherapy in a phase 3 trial. METHODS. Patients received 3 cycles of preoperative epirubicin þ ifosfamide with or without radiotherapy. The diagnostic concordance between RECIST and Choi criteria and their correlation with overall survival (OS) and freedom from progression (FFP) were evaluated in a univariate Cox regression model. RESULTS. In 243 of 321 eligible patients, RECIST, Choi criteria, and histology were predictive for OS and FFP. In the subgroup of 69 patients who received chemotherapy alone and were evaluable by both RECIST and Choi criteria, Choi criteria were associated significantly with OS and FFP, whereas RECIST predicted only FFP, and the pattern of agreement observed between the 2 criteria was unsatisfactory. On a dichotomous scale, comparing objective response (complete and partial responses) and lack of response (stable and progressive disease) to preoperative chemotherapy according to RECIST and Choi criteria, only Choi criteria were predictive of OS and FFP, and fair agreement between RECIST and Choi criteria was observed. When lack of progression and progression were compared (complete and partial responses þ stable disease vs progressive disease), both assessment criteria were significantly predictive of OS and FFP, and there was substantial agreement between the 2 criteria. CONCLUSIONS. Response to chemotherapy with or without radiotherapy was associated with a better outcome in patients with high-risk soft tissue sarcoma. Choi criteria were better predictors than RECIST in patients who received preoperative chemotherapy alone. Cancer 2012;118:5857-66.

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Section: Functional Imaging Techniques: Technical Basesmentioning

confidence: 99%

“…DWI enables the visualization of Brownian random motions of water molecules in the extracellular, intracellular, and intravascular spaces [5] . DWI provides information on tissue cellularity and integrity of cell membranes, since the degree of restriction to water diffusion in biological tissues is inversely correlated to these features [6][7][8][9] .Restricted diffusion is present in tissues with narrowed extracellular spaces as a consequence of a high cellular density, which increases the number of hydrophobic cellular membranes, whereas in cystic or necrotic lesions water diffusion is relatively ''free'' [10] . The b value is a technical parameter that regulates the sensitivity of this sequence to water molecules' diffusion.…”

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confidence: 99%

Prognostication and response assessment in liver and pancreatic tumors: The new imaging

Robertis¹,

Martini²,

Demozzi³

et al. 2015

WJG

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Diffusion-weighted imaging (DWI), dynamic contrastenhanced magnetic resonance imaging (DCE-MRI) and perfusion computed tomography (CT) are technical improvements of morphologic imaging that can evaluate functional properties of hepato-bilio-pancreatic tumors during conventional MRI or CT examinations. Nevertheless, the term "functional imaging" is commonly used to describe molecular imaging techniques, as positron emission tomography (PET) CT/MRI, which still represent the most widely used methods for the evaluation of functional properties of solid neoplasms; unlike PET or single photon emission computed tomography, functional imaging techniques applied to conventional MRI/CT examinations do not require the administration of radiolabeled drugs or specific equipments. Moreover, DWI and DCE-MRI can be performed during the same session, thus providing a comprehensive "one-step" morphological and functional evaluation of hepato-bilio-pancreatic tumors. Literature data reveal that functional imaging techniques could be proposed for the evaluation of these tumors before treatment, given that they may improve staging and predict prognosis or clinical outcome. Microscopic changes within neoplastic tissues induced by treatments can be detected and quantified with functional imaging, therefore these techniques could be used also for posttreatment assessment, even at an early stage. or altered cellular membranes will present diffusion restriction, which is depicted as signal hyperintensity areas on high b-value DW images and hypointensity on the apparent diffusion coefficient (ADC) maps; ADC measurement can also quantify water molecules' diffusion. As dedifferentiation or therapies may induce microscopic changes in neoplastic tissues that could modify water molecules' diffusion, DWI can distinguish between different degrees of malignancy and can be also proposed for post-treatment monitoring. Moreover, DWI can be performed in a single session with DCE-MRI, thus providing a comprehensive "one-step" morphological and functional evaluation of hepatobilio-pancreatic tumors.Perfusion imaging techniques evaluate changes in signal intensity (DCE-MRI) or density (pCT) after contrast medium injection, being therefore able to assess microvascularization through the evaluation of the dynamics of contrast medium distribution from vessels to the neoplastic tissue. Perfusion parameters are therefore theoretically good candidates for the evaluation of microscopic vascular differences between lesions with different pathological grade and for the assessment of treatment response, especially after chemoembolization or during treatments with antiangiogenic drugs.This editorial analyzes up-to-date literature data regarding the application of functional imaging techniques, apart from molecular imaging, to hepatic and pancreatic tumors, with particular emphasis on correlations to pathological features, prognostic stratification and therapeutic response assessment. FUNCTIONAL IMAGING TECHNIQUES: TECHNICAL BASESIn 1965 Stejskal and Tanne...

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Osteogenic sarcoma: noninvasive in vivo assessment of tumor necrosis with diffusion-weighted MR imaging.

Cited by 180 publications

References 0 publications

Characterization of chondroblastic osteosarcoma: Gadolinium‐enhanced versus diffusion‐weighted MR imaging

Characterization of chondroblastic osteosarcoma: Gadolinium‐enhanced versus diffusion‐weighted MR imaging

Tumor response assessment by modified Choi criteria in localized high‐risk soft tissue sarcoma treated with chemotherapy

Prognostication and response assessment in liver and pancreatic tumors: The new imaging

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