Osteogenic Sarcoma Metastatic to the Choroid

Spaulding, Abbot G.; Woodfin, M. Clarke

doi:10.1001/archopht.1968.00980050086013

Cited by 10 publications

(9 citation statements)

References 3 publications

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“…Several instances of ocular spread of various carcinomatous and sarcomatous malignancies have been noted in the veterinary literature [1 , 2,16]. In addition, osteosarcoma metastatic to the choroid has been described in man (17,24]. No abnormalities of long bones suggestive of primary tumor site were apparent, however, on physical examination of this cat at presentation.…”

Section: Discussionmentioning

confidence: 94%

Osteosarcoma in a Phthisical Feline Eye

et al. 1983

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Abstract. Eight years ago a cat sustained injury to the left globe and phthisis bulbi ensued. Two months prior to presentation, a firm intraorbital and periorbital mass developed and enucleation was done; histologic examination revealed osteogenic sarcoma. This is the first histologically documented report of osteosarcoma occurring in association with phthisis bulbi.Intraocular bone formation has been noted in a variety of conditions affecting eyes in man and animals [7,15]. Although intraocular ossification is a relatively frequent finding on examination of enucleated globes, we found only one report in the literature of osteogenic sarcoma occurring in a globe previously known to contain bone [8]. This paper describes a case of osteogenic sarcoma in a phthisical eye of a cat. Case HistoryA ten-year-old female, gray-white, domestic short-haired cat sustained an injury to the left globe eight years ago, with the subsequent development of phthisis bulbi. In late January 1980, a firm enlarging mass was described in the left orbit and was interpreted clinically to represent enlargement of the phthisical eye. A general physical examination revealed no swellings involving the long bones, ribs, or other skeletal structures. Topical therapy did not resolve the orbital mass. Mineralization of orbital and periorbital tissues was found in skull radiographs. No osteolysis or periosteal elevation involving the orbital rim or zygomatic arch was present. The cat was referred for surgery and enucleation was done.Following discharge, the cat became lethargic and anorectic, soon developed seizures, and subsequently became stuporous. The cat continued to deteriorate neurologically and was killed. Permission for necropsy was denied. ResultsOn gross examination the enucleation specimen consisted of two crescentic masses of tissue measuring 1.5 X 1.5 X 0.6 em. One crescentic mass was tan in color and lobulated on its margin. The boundaries of the globe were not well-defined grossly.Microscopic examination revealed a globe containing viable bone, necrotic bone, and a neoplastic growth. The only recognizable anterior segment structures were the 209

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Section: Discussionmentioning

confidence: 94%

Osteosarcoma in a Phthisical Feline Eye

et al. 1983

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“…To our knowledge, there have been 9 published cases of intraocular metastases from bone sarcoma [5, 6, 8-14], only 2 of which were from chondrosarcoma [5, 6]. In 1996, George and Zamber [5] described the first case of chondrosarcoma metastatic to the eye.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Chondrosarcoma Metastasis to the Choroid

Kim¹,

Wong²,

Lu³

et al. 2019

Ocul Oncol Pathol

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We report a rare case of chondrosarcoma metastatic to the choroid. A 64-year-old male with a history of chondrosarcoma metastatic to the lungs and to the spine presented with blurred vision. A choroidal tumor was found. Fine-needle biopsy confirmed the histologic identity of the tumor as chondrosarcoma. Metastatic spread of chondrosarcoma to the eye is extremely rare. When present, lesions may grow rapidly, and systemic prognosis is poor. Co-management with medical oncology is of utmost importance. This is the third case of chondrosarcoma metastatic to the choroid in the literature and the first with bilateral involvement.

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“…Metastatic osteosarcoma of the eye, a rarely reported entity, can involve eyelid choroid or orbital strectures [1][2][3][4][5][6][7][8]. To date there are only three case reports of osteosarcoma with orbital metastasis.…”

Section: Discussionmentioning

confidence: 99%

Orbital metastasis: a rare presentation of osteosarcoma

et al. 2007

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Non-pulmonary metastases in osteosarcoma are increasingly recognized because of improved longevity in patients receiving modern treatment. One rare site of metastasis is the orbit, with only three cases reported so far. This report describes a 16-year-old male patient, who underwent above-knee amputation for right tibial osteosarcoma and later presented with a painful protrusion of the right eyeball and near-normal vision. The uncommon features in the present case are the site of metastasis and near-normal vision.

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Osteogenic Sarcoma Metastatic to the Choroid

Cited by 10 publications

References 3 publications

Osteosarcoma in a Phthisical Feline Eye

Osteosarcoma in a Phthisical Feline Eye

Chondrosarcoma Metastasis to the Choroid

Orbital metastasis: a rare presentation of osteosarcoma

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