Osteogenic response to porous hydroxyapatite ceramics under the skin of dogs

Yamasaki, Hiroshi; Sakai, Hidetaka

doi:10.1016/0142-9612(92)90054-r

Cited by 251 publications

(177 citation statements)

References 22 publications

Supporting

Mentioning

167

Contrasting

Unclassified

Order By: Relevance

“…In the modern fields of the third generation bioceramics (Hench) or BIOceramics (Anderson), the full potential of calcium orthophosphates has only begun to be recognized. Namely, calcium orthophosphates, which were intended as osteoconductive bioceramics in the past, stand for materials to fabricate osteoinductive implants nowadays [177,459,504,[608][609][610][611][612][613][614][615][616][617][618][619][620][621]. The initial steps in this direction have been already made by both fabricating BCP-based scaffolds for bone tissue engineering through the design of controlled 3D-porous structures and increasing the biological activity through development of novel ion-substituted calcium orthophosphate bioceramics [12,461].…”

Section: Discussionmentioning

confidence: 99%

“…The effect of a HA-based biomaterial on gene expression in osteoblast-like cells was reported as well [766]. To conclude this part, the excellent biocompatibility of calcium orthophosphate bioceramics, its possible osteoinductivity [177,459,504,[608][609][610][611][612][613][614][615][616][617][618][619][620][621] and a high affinity for drugs [767], proteins and cells [786] make them very functional for the tissue engineering applications. The feasible production of scaffolds with tailored structures and properties opens up a spectacular future for calcium orthophosphates [766][767][768][769][770][771][772][773][774].…”

Section: Bioceramic Scaffolds From Calcium Orthophosphatesmentioning

confidence: 99%

See 1 more Smart Citation

Medical Application of Calcium Orthophosphate Bioceramics

Dorozhkin¹

2011

BIO

View full text Add to dashboard Cite

In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Bioceramic Scaffolds From Calcium Orthophosphatesmentioning

confidence: 99%

Medical Application of Calcium Orthophosphate Bioceramics

Dorozhkin¹

2011

BIO

View full text Add to dashboard Cite

show abstract

“…Habibovic et al (2005) investigated a 3D microenvironment of osteoinductive biomaterials and discovered that the presence of micropores within macropore walls was an essential prerequisite for osteoinduction. On the other hand, for the biological factors, these osteoinductive Ca-P biomaterials were found to be animal-species dependent (Ripamonti, 1991c;Ducheyne and Cuckler, 1992;Yamasaki and Sakai, 1992;Green et al, 1995;Nihouannen et al, 2005;Fellah et al, 2008). Based on these studies, osteogenesis was reported in baboons, monkeys, pigs, dogs, goats, and rabbits after undergoing different types of implantation (Ripamonti, 1991b;1996;Yang et al, 1997;Yuan et al, 2002;2006;Ye et al, 2007;Nihouannen et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Osteoinduction by Ca-P biomaterials implanted into the muscles of mice

Yang

Cheng

et al. 2011

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Abstract:The osteoinduction of porous biphasic calcium phosphate ceramics (BCP) has been widely reported and documented, but little research has been performed on rodent animals, e.g., mice. In this study, we report osteoinduction in a mouse model. Thirty mice were divided into two groups. BCP materials (Sample A) and control ceramics (Sample B) were implanted into the leg muscle, respectively. Five mice in each group were killed at 15, 30, and 45 d after surgery. Sample A and Sample B were harvested and used for hematoxylin and eosin (HE) staining, immunohistochemistry (IHC) staining, and Alizarin Red S staining to check bone formation in the biomaterials. Histological analysis showed that no bone tissue was formed 15 d after implantation (0/5) in either of the two groups. Newly-formed bone tissues were observed in Sample A at 30 d (5/5) and 45 d (5/5) after implantation; the average amounts of newly-formed bone tissues were approximately 5.2% and 8.6%, respectively. However, we did not see any bone tissue in Sample B until 45 d after implantation. Bone-related molecular makers such as bone morphogenesis protein-2 (BMP-2), collagen type I, and osteopontin were detected by IHC staining in Sample A 30 d after implantation. In addition, the newly-formed bone was also confirmed by Alizarin Red S staining. Because this is the report of osteoinduction in the rodent animal on which all the biotechnologies were available, our results may contribute to further mechanism research.

show abstract

“…An overwhelming majority of the early examples of CaP granule synthesis routines involved a high-temperature sintering step, which resulted in the production of wellcrystallized CaP granules [4][5][6][7][8][9][10][11][12]. High-temperature sintering as a means of production was again quite popular in the later examples of CaP granule manufacturing.…”

Section: Introductionmentioning

confidence: 99%

Preparation of porous apatite granules from calcium phosphate cement

Taş

2007

J Mater Sci: Mater Med

View full text Add to dashboard Cite

A versatile method for preparing spherical, micro-and macroporous (micro: 2-10 and macro: 150-550 lm pores), carbonated apatitic calcium phosphate (Ap-CaP) granules (2-4 mm in size) was developed by using NaCl crystals as the porogen. The entire granule production was performed between 21 and 37°C. A CaP cement powder, comprising a-Ca 3 (PO 4 ) 2 (61 wt.%), CaH-PO 4 (26%), CaCO 3 (10%) and precipitated hydroxyapatite, Ca 10 (PO 4 ) 6 (OH) 2 (3%), was dry mixed with NaCl crystals varying in size from 420 lm to 1 mm. Cement powder (35 wt.%) and NaCl (65 wt.%) mixture was kneaded with an ethanol-Na 2 HPO 4 initiator solution, and the formed dough was immediately agitated on an automatic sieve shaker for a few minutes to produce the spherical granules. Embedded NaCl crystals were then leached out of the granules by soaking them in deionized water. CaP granules were micro-and macroporous with a total porosity of 50% or more. Granules were composed of carbonated, poorly crystallized, apatitic CaP phase. These were the first spherical and porous CaP granules ever produced from a self-setting calcium phosphate cement. The granules reached their final handling strength at the ambient temperature through the cement setting reaction, without having a need for sintering.

show abstract

Osteogenic response to porous hydroxyapatite ceramics under the skin of dogs

Cited by 251 publications

References 22 publications

Medical Application of Calcium Orthophosphate Bioceramics

Medical Application of Calcium Orthophosphate Bioceramics

Osteoinduction by Ca-P biomaterials implanted into the muscles of mice

Preparation of porous apatite granules from calcium phosphate cement

Contact Info

Product

Resources

About