Osteogenic potential of simvastatin loaded gelatin-nanofibrillar cellulose-β tricalcium phosphate hydrogel scaffold in critical-sized rat calvarial defect

Sukul, Mousumi; Min, Young‐Ki; Lee, Sun-Young; Lee, Byong-Taek

doi:10.1016/j.eurpolymj.2015.10.022

Cited by 31 publications

(19 citation statements)

References 62 publications

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“…The main role of CNF in these scaffolds was to decelerate degradation, inducing sustained release of an osteoinductive biomolecule (simvastatin). The scaffolds provided enhanced bone formation and better collagen matrix deposition compared to the control . Besides the biological benefits, cellulose nanofibers have imparted printability to gelatin‐based hydrogels, wherein CNFs enhanced the structural integrity and increased the mechanical stability of the composites .…”

Section: Gelatin–polysaccharides Composites In Cell Culture and Tissumentioning

confidence: 99%

“…The scaffolds provided enhanced bone formation and better collagen matrix deposition compared to the control. 100 Besides Bacterial cellulose-gelatin composite hydrogels have been used as versatile 3D scaffolds for culturing breast cancer cells to provide in vitro models of tumor microenvironments. 102 Significant function of human breast cancer cell line (MDA-MD-231) in these scaffolds was reported.…”

Section: Gelatin-cellulosementioning

confidence: 99%

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Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Afewerki

Sheikhi

Kannan

et al. 2018

Bioengineering & Transla Med

268

210

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Gelatin is a promising material as scaffold with therapeutic and regenerative characteristics due to its chemical similarities to the extracellular matrix (ECM) in the native tissues, biocompatibility, biodegradability, low antigenicity, cost‐effectiveness, abundance, and accessible functional groups that allow facile chemical modifications with other biomaterials or biomolecules. Despite the advantages of gelatin, poor mechanical properties, sensitivity to enzymatic degradation, high viscosity, and reduced solubility in concentrated aqueous media have limited its applications and encouraged the development of gelatin‐based composite hydrogels. The drawbacks of gelatin may be surmounted by synergistically combining it with a wide range of polysaccharides. The addition of polysaccharides to gelatin is advantageous in mimicking the ECM, which largely contains proteoglycans or glycoproteins. Moreover, gelatin–polysaccharide biomaterials benefit from mechanical resilience, high stability, low thermal expansion, improved hydrophilicity, biocompatibility, antimicrobial and anti‐inflammatory properties, and wound healing potential. Here, we discuss how combining gelatin and polysaccharides provides a promising approach for developing superior therapeutic biomaterials. We review gelatin–polysaccharides scaffolds and their applications in cell culture and tissue engineering, providing an outlook for the future of this family of biomaterials as advanced natural therapeutics.

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Section: Gelatin–polysaccharides Composites In Cell Culture and Tissumentioning

confidence: 99%

Section: Gelatin-cellulosementioning

confidence: 99%

Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Afewerki

Sheikhi

Kannan

et al. 2018

Bioengineering & Transla Med

268

210

View full text Add to dashboard Cite

show abstract

“…Furthermore, local delivery of SV at the desired site of action has been shown to have positive effects on bone formation. 15,16 Although there are some reports about the administration of SV enhancing the bone regeneration around implants, few studies involved the relationship between local delivery of SV and implant-bone interface, especially for the in vivo studies in either normal or osteoporosis models. 17,18 As the polymeric micellar system is considered promising for enhancing the bioavailability and reducing the toxic side effects of hydrophobic drugs, SV-loaded polymeric micelles with sustained-release profiles were developed with preferable bioavailability in our previous study.…”

Section: Introductionmentioning

confidence: 99%

Study of a new bone-targeting titanium implant–bone interface

Liu¹,

Zhang²,

Li³

et al. 2016

IJN

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“…Statins, HMG-CoA reductase inhibitors, can have pleiotropic effects on bone formation by up-regulating BMP-2 mRNA expression [27]. Several studies have been performed to investigate the effects of systemic use of statins on bone healing but there are limited studies on local application.…”

Section: Resultsmentioning

confidence: 99%

Histopathologic evaluation of the effects of local simvastatin application and photobiomodulation by light-emitting diode on bone healing of rat calvarial defects

Burdurlu

Deniz

Olgaç

2017

Biotechnology & Biotechnological Equipment

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The purpose of this study was to evaluate the effect of photombiomodulation (PBM) and locally applied simvastatin on bone formation in critical size defects of the experimental rat model calvarium. A total of 28 Spraque-Dawley male rats, mean age of 18 weeks, were used. Bilateral 5 mm critical sized calvarial defects were created. Then 0.5 mg/mL simvastatin solution was inoculated into gelatin sponge and locally applied on one side. The other side served as control.Half of the animals were subjected to PBM treatment and the remaining half were left for spontaneous healing. The animals were sacrificed by guillotine at days 8 and 15. The specimens were histopathologically analysed. The histopathologic evaluation revealed that the new bone formation levels were significantly higher at the 15th day compared to the 8th day. The bone formation levels with PBM and simvastatin treatment either combined or applied individually were significantly higher than the control ones. PBM and local simvastatin applications had favourable effects on the early phase of new bone formation and reduced the bone healing period in the rat model. Further human trials must be performed for evaluation of the reliability of this protocol.

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Osteogenic potential of simvastatin loaded gelatin-nanofibrillar cellulose-β tricalcium phosphate hydrogel scaffold in critical-sized rat calvarial defect

Cited by 31 publications

References 62 publications

Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Study of a new bone-targeting titanium implant–bone interface

Histopathologic evaluation of the effects of local simvastatin application and photobiomodulation by light-emitting diode on bone healing of rat calvarial defects

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Osteogenic potential of simvastatin loaded gelatin-nanofibrillar cellulose-β tricalcium phosphate hydrogel scaffold in critical-sized rat calvarial defect

Cited by 31 publications

References 62 publications

Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Study of a new bone-targeting titanium implant&ndash;bone interface

Histopathologic evaluation of the effects of local simvastatin application and photobiomodulation by light-emitting diode on bone healing of rat calvarial defects

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Product

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Study of a new bone-targeting titanium implant–bone interface