Osteogenic potential of a 3D printed silver nanoparticle-based electroactive scaffold for bone tissue engineering using human Wharton's jelly mesenchymal stem cells

Abstract

This study aims to perform biological assessments of an electroactive scaffold based on PCL/AgNPs that was fabricated using a green synthesis approach followed by a 3D printing method without toxic solvents, which has not been explored previously.

Silver/Graphene Oxide Nanostructured Coatings for Modulating the Microbial Susceptibility of Fixation Devices Used in Knee Surgery

“…For instance, the use of AgNPs as doping agents in bone cements based on calcium phosphate [125] and resin [126] has been reported as a promising strategy for the management of periprosthetic infections caused by relevant Gram-negative and Gram-positive strains. The sole modification of titanium surfaces [127,128] and biodegradable polyester scaffolds [129] with AgNPs has been validated for the fabrication of osteogenic and anti-infective orthopedic devices. In comparison with bare titanium-based devices, implants coated with AgNP-loaded organosilica-based hybrid materials [130] and wires modified with silver multilayer coatings [131] reduced post-implantation in-flammation and led to enhanced bone healing during ligament reconstruction surgery in animal models.…”