Antimicrobial Metal and Metal Oxide Nanoparticles in Bone Tissue Repair

Shineh, Ghazal; Mobaraki, Mohammadmahdi; Afzali, Elham; Alakija, Femi; Velisdeh, Zeinab Jabbari; Mills, David K.

doi:10.1007/s44174-024-00159-3

Cited by 3 publications

(2 citation statements)

References 198 publications

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“…In the case of both coated and uncoated IONPs, it was observed that their sizes varied within a range of approximately 6–254 nm and 3–200 nm, respectively, when employing the COP and GRS methods. However, it is often observed that smaller-sized IONPs tend to interact more frequently with pathogenic bacteria, resulting in dose reduction. − Consequently, smaller IONPs exhibit a greater level of antibacterial activity. − …”

Section: Parameters Influencing Antimicrobial Activitymentioning

confidence: 99%

Influence of Physicochemical Properties of Iron Oxide Nanoparticles on Their Antibacterial Activity

Shoudho,

Uddin,

Rumon

et al. 2024

ACS Omega

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The increasing occurrence of infectious diseases caused by antimicrobial resistance organisms urged the necessity to develop more potent, selective, and safe antimicrobial agents. The unique magnetic and tunable properties of iron oxide nanoparticles (IONPs) make them a promising candidate for different theragnostic applications, including antimicrobial agents. Though IONPs act as a nonspecific antimicrobial agent, their antimicrobial activities are directly or indirectly linked with their synthesis methods, synthesizing precursors, size, shapes, concentration, and surface modifications. Alteration of these parameters could accelerate or decelerate the production of reactive oxygen species (ROS). An increase in ROS role production disrupts bacterial cell walls, cell membranes, alters major biomolecules (e.g., lipids, proteins, nucleic acids), and affects metabolic processes (e.g., Krebs cycle, fatty acid synthesis, ATP synthesis, glycolysis, and mitophagy). In this review, we will investigate the antibacterial activity of bare and surface-modified IONPs and the influence of physiochemical parameters on their antibacterial activity. Additionally, we will report the potential mechanism of IONPs' action in driving this antimicrobial activity.

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Section: Parameters Influencing Antimicrobial Activitymentioning

confidence: 99%

Influence of Physicochemical Properties of Iron Oxide Nanoparticles on Their Antibacterial Activity

Shoudho,

Uddin,

Rumon

et al. 2024

ACS Omega

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“…To address these challenges, innovative approaches such as targeted therapies are being explored. These therapies allow for the local administration of drugs in higher concentrations, minimizing systemic toxicity and improving patient survival [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. Currently, anti-cancer drugs like 5-fluorouracil, paclitaxel, cisplatin, and docetaxel are used in oral cancer treatment [ 47 , 48 ].…”

Section: Introductionmentioning

confidence: 99%

Application of Scaffold-Based Drug Delivery in Oral Cancer Treatment: A Novel Approach

Saberian,

Jenča,

Petrášová

et al. 2024

Pharmaceutics

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This comprehensive review consolidates insights from two sources to emphasize the transformative impact of scaffold-based drug delivery systems in revolutionizing oral cancer therapy. By focusing on their core abilities to facilitate targeted and localized drug administration, these systems enhance therapeutic outcomes significantly. Scaffolds, notably those coated with anti-cancer agents such as cisplatin and paclitaxel, have proven effective in inhibiting oral cancer cell proliferation, establishing a promising avenue for site-specific drug delivery. The application of synthetic scaffolds, including Poly Ethylene Glycol (PEG) and poly(lactic-co-glycolic acid) (PLGA), and natural materials, like collagen or silk, in 3D systems has been pivotal for controlled release of therapeutic agents, executing diverse anti-cancer strategies. A key advancement in this field is the advent of smart scaffolds designed for sequential cancer therapy, which strive to refine drug delivery systems, minimizing surgical interventions, accentuating the significance of 3D scaffolds in oral cancer management. These systems, encompassing local drug-coated scaffolds and other scaffold-based platforms, hold the potential to transform oral cancer treatment through precise interventions, yielding improved patient outcomes. Local drug delivery via scaffolds can mitigate systemic side effects typically associated with chemotherapy, such as nausea, alopecia, infections, and gastrointestinal issues. Post-drug release, scaffolds foster a conducive environment for non-cancerous cell growth, adhering and proliferation, demonstrating restorative potential. Strategies for controlled and targeted drug delivery in oral cancer therapy span injectable self-assembling peptide hydrogels, nanocarriers, and dual drug-loaded nanofibrous scaffolds. These systems ensure prolonged release, synergistic effects, and tunable targeting, enhancing drug delivery efficiency while reducing systemic exposure. Smart scaffolds, capable of sequential drug release, transitioning to cell-friendly surfaces, and enabling combinatorial therapy, hold the promise to revolutionize treatment by delivering precise interventions and optimized outcomes. In essence, scaffold-based drug delivery systems, through their varied forms and functionalities, are reshaping oral cancer therapy. They target drug delivery efficiency, diminish side effects, and present avenues for personalization. Challenges like fabrication intricacy, biocompatibility, and scalability call for additional research. Nonetheless, the perspective on scaffold-based systems in oral cancer treatment is optimistic, as ongoing advancements aim to surmount current limitations and fully leverage their potential in cancer therapy.

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R-CovNet: hybridized model for automated classification of COVID-19 cases from chest X-ray images

Bania,

Sarmah

2024

Multimed Tools Appl

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Antimicrobial Metal and Metal Oxide Nanoparticles in Bone Tissue Repair

Cited by 3 publications

References 198 publications

Influence of Physicochemical Properties of Iron Oxide Nanoparticles on Their Antibacterial Activity

Influence of Physicochemical Properties of Iron Oxide Nanoparticles on Their Antibacterial Activity

Application of Scaffold-Based Drug Delivery in Oral Cancer Treatment: A Novel Approach

R-CovNet: hybridized model for automated classification of COVID-19 cases from chest X-ray images

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