Osteogenic Hydrogels: Gelatin Templated Polypeptide Co‐Cross‐Linked Hydrogel for Bone Regeneration (Adv. Healthcare Mater. 1/2020)

Qiao, Yusen; Liu, Xingzhui; Zhou, Xichao; Zhang, Wen; Xiao, Wei; Pan, Guoqing; Cui, Wenguo; Santos, Hélder A.; Shi, Qin

doi:10.1002/adhm.202070001

Cited by 15 publications

(11 citation statements)

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“…To fabricate adhesive micromotor carriers, the resultant colloidal suction‐cup‐like microparticles were employed as templates for biocompatible hydrogel to replicate, as schemed in Figure 3 a . To improve the biocompatibility, methacrylated gelatin (GelMA), a kind of hydrogel with good biocompatibility, [ 31 , 32 ] was utilized to replicate the structure of the suction‐cup‐like colloidal microparticles Figure S3 , Supporting Information. First, these suction‐cup‐like microparticles were pre‐dried and then soaked in a viscous melted gelatin solution.…”

Section: Resultsmentioning

confidence: 99%

Suction‐Cup‐Inspired Adhesive Micromotors for Drug Delivery

et al. 2021

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Micromotors have opened novel avenues for drug delivery due to their capacity for self-propelling. Attempts in this field trend towards ameliorating their functions to promote their clinical applications. In this paper, an ingenious suction-cup-inspired micromotor is presented with adhesive properties for drug delivery in the stomach. The micromotors are fabricated by using hydrogel replicating the structure of suction-cup-like microparticles, which derive from self-assembly of colloidal crystals under rapid solvent extraction, followed by loading magnesium (Mg) in the bottom spherical surface. The Mg-loaded micromotors can realize spontaneous movement due to the continual generation of hydrogen bubbles in gastric juice. The combination of unique suction-cup-like structure with excellent motion performance makes the micromotor an ideal carrier for drug delivery as they can efficiently adhere to the tissue. Moreover, benefiting from the porous structure, the hydrogel micromotors exhibit a high volume-surface ratio, which enables efficient drug loading. It is demonstrated that the suction-cup-inspired micromotors can adhere efficiently to the ulcer-region in the stomach and release drugs due to their distinctive architecture and spontaneous motion, exhibiting desirable curative effect of gastric ulcer. Thus, the suction-cup-inspired micromotors with adhesive properties are expected to advance the development of micromotor in clinical applications.

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Section: Resultsmentioning

confidence: 99%

Suction‐Cup‐Inspired Adhesive Micromotors for Drug Delivery

et al. 2021

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“…After reading the full text, only 23 literatures finally met the inclusion criteria. The required data were extracted from the 23 included literatures, and the basic information of the included literatures are shown in Table . − The compressive moduli of GelMA-based composites, that is, the experimental group, and pure GelMA, that is, the control group, are shown in Table . The literature screening flow chart is shown in Figure .…”

Section: Results and Discussionmentioning

confidence: 99%

Effect of Different Additives on the Mechanical Properties of Gelatin Methacryloyl Hydrogel: A Meta-analysis

et al. 2021

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Gelatin methacryloyl (GelMA) hydrogel has adjustable physicochemical properties and a three-dimensional network structure for cell growth and hence a hot issue in the field of tissue engineering. However, its poor mechanical properties limit the application in the scaffold, especially as a bone scaffold. To date, many research studies have been carried out by adding some additives into GelMA to construct GelMA-based composites to improve the mechanical properties. However, there is a controversy as to whether the additives can improve the mechanical properties of GelMA. Herein, meta-analysis was used to evaluate the influence of the additives on the mechanical properties of GelMA-based composites, which can provide reference for the further enhancement of mechanical properties of GelMA. In this study, meta-analysis was adopted to investigate the influence of additives on the mechanical properties of GelMA composites; composites with different concentrations of GelMA, that is, ≥10% (w/v), 5–10% (w/v), and ≤5% (w/v) were found in 23 literatures and heterogeneity could be found among these references. Accordingly, it is found that additives can improve the mechanical properties in each concentration.

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“…Synthesis of 4OI-BP@Gel Solutions: To acquire the 4OI-BP@Gel hydrogel, 5% (w/v) GelMA [38] and 50 μg/mL of 4OI-BP were fully dissolved in deoxygenated water. Specifically, 4OI-and 4OI-BP-loaded GelMA hydrogels were named 4OI@Gel and 4OI-BP@Gel, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…[36,37] In the gelatin process, shown in Figure 1H, the GelMA prepolymer was modified to a hydrogel via UV light at 365 nm for 30 Seconds. [38] The 4OI-BP@Gel can also easily form hydrogel under the same UV light. Scanning electron microscopy (SEM) was used to observe the pore morphology of the hydrogel (Figure 1G).…”

Section: Characterizations Of Bp Nanosheets Bp-polyethylene Glycol (P...mentioning

confidence: 99%

Bioinspired Multifunctional Black Phosphorus Hydrogel with Antibacterial and Antioxidant Properties: A Stepwise Countermeasure for Diabetic Skin Wound Healing

Ding

Sun

et al. 2022

Adv Healthcare Materials

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Cutaneous wound healing, especially diabetic wound healing, is a common clinical challenge. Reactive oxygen species (ROS) and bacterial infection are two major detrimental states that induce oxidative stress and inflammatory responses and impede angiogenesis and wound healing. A derivative of the metabolite itaconate, 4-octyl itaconate (4OI) has attracted increasing research interest in recent years due to its antioxidant and anti-inflammatory properties. In this study, 4OI-modified black phosphorus (BP) nanosheets are incorporated into a photosensitive, multifunctional gelatin methacrylamide hydrogel to produce a new photothermal therapy (PTT) and photodynamic therapy (PDT) system with antibacterial and antioxidant properties for diabetic wound regeneration. Under laser irradiation, the 4OI-BP-entrapped hydrogel enables rapid gelation, forming a membrane on wounds, and offers high PTT and PDT efficacy to eliminate bacterial infection. Without laser irradiation, BP acts as a carrier and controls the release of 4OI, with which it synergistically enhances antioxidant activity, thus alleviating excessive ROS damage to endothelial cells, promoting neovascularization, and facilitating faster diabetic wound closure. These findings indicate that 4OI-BP-entrapped multifunctional hydrogel provides a stepwise countermeasure with antibacterial and antioxidant properties for enhanced diabetic wound healing and may lead to novel therapeutic interventions for diabetic ulcers.

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Osteogenic Hydrogels: Gelatin Templated Polypeptide Co‐Cross‐Linked Hydrogel for Bone Regeneration (Adv. Healthcare Mater. 1/2020)

Cited by 15 publications

References 0 publications

Suction‐Cup‐Inspired Adhesive Micromotors for Drug Delivery

Suction‐Cup‐Inspired Adhesive Micromotors for Drug Delivery

Effect of Different Additives on the Mechanical Properties of Gelatin Methacryloyl Hydrogel: A Meta-analysis

Bioinspired Multifunctional Black Phosphorus Hydrogel with Antibacterial and Antioxidant Properties: A Stepwise Countermeasure for Diabetic Skin Wound Healing

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