Osteogenesis Hormonal Regulation: Review

Abstract

Background. The endocrine system occupies a leading place not only in the regulation of growth and development mechanisms, but also in compensation reactions when the body is exposed to extreme factors. Coordinated hormonal regulation contributes to the correct response of the macroorganism adaptive processes, aimed at restoring and maintaining homeostasis. A cascade of endocrine changes accompanies the processes of both physiological and reparative regeneration of bone tissue at all its stages. The aim of the study was to analyze the currently known mechanisms of hormonal regulation of physiological and reparative bone tissue regeneration. Materials and Methods. The search and analysis of scientific literary sources was carried out in the electronic databases PubMed and eLIBRARY. Search depth 10 years. Results. The review considers both fundamental aspects and new data on the main histogenetic mechanisms of osteogenesis hormonal regulation. The ways and points of interaction of the endocrine and skeletal systems are highlighted, the main functions of hormones in the participation of bone remodeling in different age periods are determined. Conclusion. In violations of physiological regulation, hormonal imbalance is assigned a key role, while under conditions of reparative osteogenesis, the role of qualitative and dynamic changes in the endocrine system has been studied insufficiently. Hormonal regulation of reparative regeneration to date has no clear assessment criteria and requires further research.