Osteoclastos: mucho más que células remodeladoras del hueso

Arboleya, Luis; Castañeda, Santos

doi:10.4321/s1889-836x2014000400007

Cited by 4 publications

(1 citation statement)

References 117 publications

(112 reference statements)

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“…Two such cell types that are not targeted by current drugs but are critical in RA pathogenesis are the fibroblast-like synovial (FLS) cells and the osteoclasts. The two cells contribute to joint damage and deformities resulting in long-term sequelae, whereas the FLS also contribute to inflammation and disease persistence by adopting a characteristic aggressive phenotype (6)(7)(8)(9)(10). We have recently reported the involvement of non-canonical WNT5A in the aggressive phenotype of RA FLS.…”

Section: Introductionmentioning

confidence: 99%

ROCK inhibition with Y-27632 reduces joint inflammation and damage in serum-induced arthritis model and decreases in vitro osteoclastogenesis in patients with early arthritis

Rodríguez-Trillo

Pena

García³

et al. 2022

Front. Immunol.

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Rheumatoid arthritis (RA) is a common chronic inflammatory disease affecting primarily peripheral joints, which is only partially controlled with current treatments. RA leads to pain, disability, deformities, and life expectancy shortening. Its pathogenesis is complex involving multiple cell types and signaling pathways that we incompletely understand. One of the pathways we have elucidated starts with WNT5A signaling and contributes to the aggressive phenotype of the RA synoviocytes through RYK-RhoA/ROCK signaling. Now, we have explored the contribution of ROCK to arthritis in vivo, using the K/BxN serum-transfer arthritis model; and to osteoclastogenesis, using the arthritis model and cells from patients with inflammatory arthritis. The mice and cells were treated with the ROCK inhibitor Y-27632 that caused a significant improvement of arthritis and reduction of osteoclastogenesis. The improvement in mouse arthritis was observed in the clinical evaluation and, histologically, in synovial inflammation, cartilage damage, bone erosion, and the abundance of multinucleated TRAP+ cells. Expression of inflammatory mediators in the arthritic joints, as assessed by real-time PCR, was also significantly reduced. The effect on bone was confirmed with in vitro assays using bone marrow precursors of arthritic mice and peripheral blood monocytes of patients with inflammatory arthritis. These assays showed dramatically reduced osteoclastogenesis and bone resorption. Overall, our findings suggest that ROCK inhibition could be part of a therapeutic strategy for RA by its dual action on inflammation and bone erosion.

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Section: Introductionmentioning

confidence: 99%

ROCK inhibition with Y-27632 reduces joint inflammation and damage in serum-induced arthritis model and decreases in vitro osteoclastogenesis in patients with early arthritis

Rodríguez-Trillo

Pena

García³

et al. 2022

Front. Immunol.

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Comparative study of the effects of osteoprotegerin and testosterone on bone quality in male orchidectomised rats

et al. 2018

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ORX resulted in femoral and vertebral bone loss and in microarchitectural deterioration. Treatment with OPG-Fc and testosterone recovered lumbar (L) and femoral (F) bone mineral densitometry bone mineral density (BMD) to SHAM levels. Femoral BMD was significantly higher after treatment with OPG-Fc than after testosterone treatment due to the presence of osteopetrotic changes in the metaphyseal region of long bones. Serum levels of ALP and CTX increased, while OPG levels were unchanged in ORX rats. Treatment with OPG-Fc decreased the levels of BGP, ALP, and CTX. Treatment with testosterone maintained biochemical markers of bone turnover at levels similar to or higher than those of ORX rats.

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Biomechanical Study of Proximal Femur for Designing Stems for Total Hip Replacement

2020

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Innovative hip implants should be designed in accordance with biomechanical models of the proximal femur and take into account both body weight and muscle action in order to improve usability and biomimetic performance. This article proposes a finite element analysis of the proximal femur using both cortical and trabecular regions and employing transverse isotropic properties with standardized loads taken from active and young patients. Maximum principal stresses are plotted to show the mechanical behavior of the femur and grouped to evaluate stress shielding. Tsai–Wu and the maximum principal stress fields are useful for finding the areas more prone to failure and analyzing the influence of the stems on femoral mechanics. Other parameters, such as the stem material, absence of neck and osteotomy level, are explained. This paper is expected to provide a guide for designers and surgeons of femoral stems for assessing qualitatively and quantitatively the risks of stress shielding.

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Osteoclastos: mucho más que células remodeladoras del hueso

Cited by 4 publications

References 117 publications

ROCK inhibition with Y-27632 reduces joint inflammation and damage in serum-induced arthritis model and decreases in vitro osteoclastogenesis in patients with early arthritis

ROCK inhibition with Y-27632 reduces joint inflammation and damage in serum-induced arthritis model and decreases in vitro osteoclastogenesis in patients with early arthritis

Comparative study of the effects of osteoprotegerin and testosterone on bone quality in male orchidectomised rats

Biomechanical Study of Proximal Femur for Designing Stems for Total Hip Replacement

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