Osteoclast recruitment in response to human bone matrix is age related

Groessner‐Schreiber, Birte; Krukowski, Marilyn; Lyons, Catherine; Osdoby, Philip

doi:10.1016/0047-6374(92)90051-e

Cited by 37 publications

(26 citation statements)

References 27 publications

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“…In our study age influenced loss of BMD in the calcar region perhaps because thicker stems were used due to a wider femoral canal or because these patients are more sensitive to stress shielding. Differences in remodelling activity between younger and older patients have been reported, both at the cellular level [6] and at the macroscopic level [4]. Our findings suggest that younger patients may have a different remodelling pattern after insertion of orthopaedic implants.…”

Section: Discussionmentioning

confidence: 43%

Five-year DEXA study of 88 hips with cemented femoral stem

Digas

Kärrholm

2008

International Orthopaedics (SICOT)

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We performed repeated dual-energy X-ray absorptiometry (DEXA) measurements over five years in a homogeneous patient population to study the effect of a cemented stem on proximal femoral bone remodelling. Data from 88 patients (88 hips) implanted with total hip arthroplasty (THA) prostheses were extracted from three randomised studies. Femoral bone mineral density (BMD) was measured using a Lunar DPX-IQ densitometer for five years postoperatively. At one year the BMD changes had decreased between −2.0% [region of interest (ROI) 1] and −11.5% (ROI 7). During the follow-up period the BMD initially increased during the second year and thereafter decreased again in ROIs 5, 6 and 7. The loss of BMD at five years was more pronounced in region 7 (12.9%) and decreased with increasing age, total hip replacement (THR) on the right side and decreasing weight of the patient. We found that after the initial phase of early bone loss a period of recovery follows. Thereafter the BMD decreases again, which probably reflects the normal ageing of bone after uncomplicated cemented THA.Résumé Nous avons réalisé des examens avec des mesures répétées de densité osseuse (DEXA) sur une période de 5 ans dans une population homogène de patients ayant bénéficié de la mise en place d'une prothèse fémorale cimentée avec évaluation de remodelage osseux. Nous avons extrait les données de 88 patients (88 hanches) de trois études randomisées. La densité minérale osseuse fémorale a été mesurée par densitomètre Lunar DPX-IQ durant les cinq années post-opératoires. A un an, la densité minérale osseuse diminue de −2% (zone 1) et de −11,5% (zone 7). Durant la période d'observation la densité minérale osseuse augmente au cours de la deuxième année et puis diminue à nouveau en zones 5, 6 et 7. La perte de densité osseuse à cinq ans est moins importante en zone 7 (12,9%) et diminue lorsque l'âge augmente notamment du côté droit et en fonction du poids des patients. Nous avons ainsi montré, qu'après une phase initiale de déminéralisa-tion osseuse il existe une phase de reminéralisation puis la densité minérale osseuse diminue à nouveau ceci étant probablement dans les prothèses totales de hanches non compliquées le reflet de l'âge.

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Section: Discussionmentioning

confidence: 43%

Five-year DEXA study of 88 hips with cemented femoral stem

Digas

Kärrholm

2008

International Orthopaedics (SICOT)

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“…NCPs are synthesized and secreted by bone cells, and their expression is regulated, in part, by local growth factors and hormones (4-7). Accumulating evidence suggests that the extracellular matrix of bone exerts profound effects on cellular activity by retaining NCPs and growth factors that influence both immediate and long-term cell-matrix interactions (8)(9)(10)(11)(12)(13). Reduced recruitment of osteoclasts to devitalized particles of bone from human donors of increasing age suggests that bone matrix components may be partially responsible for impaired skeletal remodeling associated with aging (9).…”

Section: Introductionmentioning

confidence: 99%

Age- and gender-related changes in the distribution of osteocalcin in the extracellular matrix of normal male and female bone. Possible involvement of osteocalcin in bone remodeling.

Ingram¹,

Park²,

Clarke³

et al. 1994

J. Clin. Invest.

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IntroductionWith increasing age, bone undergoes changes in remodeling that ultimately compromise the structural integrity ofthe skeleton. The presence of osteocalcin in bone matrix may alter bone remodeling by promoting osteoclast activity. Whether ageand/or gender-related differences exist in the distribution of osteocalcin within individual bone remodeling units is not known. In this study, we determined the immunohistochemical distribution of osteocalcin in the extracellular matrix of iliac crest bone biopsies obtained from normal male and female volunteers, 20-80 yr old. Normal bone metabolism is the result of a highly integrated relationship between bone resorption and formation. With age, the structural integrity of the skeleton declines along with the functional capacity of various organ systems. Although overall bone mass decreases with age in females and males, the rate of bone loss in females is greater than males ( 1-3). The mechanisms by which bone remodeling is altered with age and gender are poorly understood. The organic phase of normal bone consists of 90% type I collagen and the remaining 10% is composed of noncollagenous proteins (NCPs).' NCPs are synthesized and secreted by bone cells, and their expression is regulated, in part, by local growth factors and hormones (4-7). Accumulating evidence suggests that the extracellular matrix of bone exerts profound effects on cellular activity by retaining NCPs and growth factors that influence both immediate and long-term cell-matrix interactions (8-13). Reduced recruitment of osteoclasts to devitalized particles of bone from human donors of increasing age suggests that bone matrix components may be partially responsible for impaired skeletal remodeling associated with aging (9).Osteocalcin is a 6.5-kD vitamin K-dependent, gamma-carboxyglutamic acid-containing NCP secreted by osteoblasts and odontoblasts. Due to its high affinity for calcium and hydroxyapatite, osteocalcin is incorporated into the extracellular matrix of bone ( 14-16). A growing body of evidence suggests that this matrix protein is involved in bone remodeling. Significant differences in the concentration ofextractable osteocalcin between cortical and trabecular bone in humans provides evidence of distinct regulatory mechanisms among these areas (10). Osteocalcin-deficient bone particles obtained from warfarn-treated rats recruit fewer osteoclasts and are resorbed less than normal particles using in vivo assays ( 1 1, 17, 18). Osteopetrotic rat bone contains low concentrations of osteocalcin, and osteoclast activity in these animals is reduced ( 19).The possibility that NCPs are involved in regulating sitespecific cell-matrix interactions is supported by studies that have immunolocalized NCPs within the extracellular matrix of bone from several species (13,(20)(21)(22). Presently, it is not known whether age or gender differences exist in the microanatomical distribution of NCPs within bone remodeling units. In this study, the immunohistochemical distribution of osteocalcin in ...

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“…In this research, the starch mixed with α-TCP not only increase the porosity, but also produce pores with sizes ranging from 30 to 90 µm (Figure 6a,b,c)). The size of these pores are comparable to that of human average cell size (74.66 ~ 82.45 µm ) [27], especially for that of osteoclast (20 ~ 150 µm) [28], which will be suitable for osteoclast to migrate in the pores and resorb the bone-like materials, thus leaving space for osteoblast (10 ~ 50 µm) [29], to make new bone tissues.…”

Section: Dense Sintered Blocks Prepared From α-Tcp and Starchmentioning

confidence: 99%

Optimization of Sintering Conditions for Improvement of Mechanical Property of a-Tricalcium Phosphate Blocks

Iy¹

2016

Glob J Biotechnol Biomater Sci

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Bioactive ceramic materials have been under research as bone substitute for several decades. To repair the high-load bearing bones, mainly cortical bones, there is a need for the substitute to possess comparable mechanical strength to cortical bone, of which the compressive strength ranges between 100 and 230 MPa. Two prevailing bone repairing material, β-tricalcium phosphate (β-TCP, β-Ca 3 (PO 4 ) 2 ) and hydroxyapatite (HAp: Ca 10 (PO 4 ) 6 (OH) 2 ) have been widely researched and sintered into dense blocks to meet the mechanical requirements. α-tricalcium phosphate (α-TCP, α-Ca 3 (PO 4 ) 2 ), a high temperature polymorph of β-TCP, received relatively less attention and α-TCP dense sintered blocks have not been reported yet. In this research, we fabricated α-TCP dense blocks by sintering under various temperatures (1150-1400 °C) and the highest compressive strength was around 230 MPa. Intermediate porous blocks (porosity: 33%) were also fabricated from mixed powder of α-TCP and starch. In vitro properties variation of the intermediate porous blocks were investigated by soaking samples in simulated body fluid (SBF) and the compressive strength was maintained above 100 MPa after soaking for 14 d.

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Osteoclast recruitment in response to human bone matrix is age related

Cited by 37 publications

References 27 publications

Five-year DEXA study of 88 hips with cemented femoral stem

Five-year DEXA study of 88 hips with cemented femoral stem

Age- and gender-related changes in the distribution of osteocalcin in the extracellular matrix of normal male and female bone. Possible involvement of osteocalcin in bone remodeling.

Optimization of Sintering Conditions for Improvement of Mechanical Property of a-Tricalcium Phosphate Blocks

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