Osteochondroma in a young cat infected by feline leukemia virus

Reis, Matheus de Oliveira; Mello, Lauren Santos de; Hesse, Kivia L.; Lorenzett, Marina Paula; Reis, Kauê Danilo Helene Lemos dos; Campos, Fabrício Souza; Roehe, Paulo Michel; Pavarini, Saulo Petinatti

doi:10.1590/0103-8478cr20151558

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…Whereas the exact incidence of OC in cats is still uncertain, Turrel and Pool (1982) reported that it accounted for 20% (3/15 cases) of primary bone tumors in cats. In most cases of OC in cats, the presence of retrovirus, especially feline leukemia virus (FeLV), has been confirmed in sera (Gradner et al, 2008; Reis et al, 2017; Rosa and Kirberger, 2012). Moreover, FeLV‐like particles, FeLV antigens or FeLV gene have been detected in proliferating bone lesions in cats with OC (Doige, 1987; Szilasi et al, 2022; Turrel and Pool, 1982).…”

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confidence: 99%

A frameshift variant in the EXT1 gene in a feline leukemia virus‐negative cat with osteochondromatosis

et al. 2022

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Osteochondromatosis is a benign proliferative disorder characterized by cartilage-capped bony protuberances. In humans and most mammals, variants in the EXT1 or EXT2 gene are strongly correlated with the etiology of osteochondromatosis. However, in cats, osteochondromatosis has only been associated with feline leukemia virus infection. In this study, to explore other factors involved in the etiology of feline osteochondromatosis, we examined the EXT1 and EXT2 genes in a feline leukemia virus-negative cat with osteochondromatosis. Genetic analysis revealed a heterozygous single base pair duplication in exon 6 of the EXT1 gene (XM_023248762.2:c.1468dupC), leading to a premature stop codon in the EXT1 protein. Notably, this frameshift variant is recognized as one of the most common pathogenic variants in human osteochondromatosis. Our data suggest for the first time that genetic variants can have etiologic roles in osteochondromatosis in cats, as in humans and other animals.

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Section: Figurementioning

confidence: 99%

A frameshift variant in the EXT1 gene in a feline leukemia virus‐negative cat with osteochondromatosis

et al. 2022

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Un caso de osteocondroma en la oreja de un gato

Polat,

Karabulut,

Ekinci

2024

Rev MVZ Córdoba

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In this case report, we aimed to share the clinical and histopathological examination and treatment process of a 6-month-old hybrid cat brought with the complaint of swelling in the medial part of the right auricle. In clinical examination, it was determined that the mass had a hard and irregular surface structure. As a result of the clinical examination, it was decided to completely extirpate the mass and send it to the pathology department. The mass was widely separated from the surrounding tissues and extirpated with the help of cautery. Microscopic examination of the mass revealed that there were chondrocytes among the dense bone cell accumulations and that they formed islands in some areas. As a result of histopathological examinations, it was determined that the suspicious mass was osteochondroma. During the postoperative examinations, it was determined that there was no recurrence or complication in the patient. As a result, it was concluded that this presentation will contribute to the literature since osteochondroma masses are rare in the ear region.

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In Situ Hybridization of Feline Leukemia Virus in a Case of Osteochondromatosis

Szilasi

Koltai

Dénes

et al. 2022

Veterinary Sciences

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Osteochondromatosis, also known as multiple cartilaginous exostosis, polyostotic osteochondroma, and multiple osteochondromas, comprises one-fifth of all primary bone tumors in cats, with no breed or sex predisposition or hereditary pattern. Unlike in dogs, horses, and humans, it is predominantly seen in young cats (2–4 years old), after the maturation of the skeleton. Although the pathogenesis of osteochondromatosis is not fully understood, it is considered to be related to infection by feline leukemia virus (FeLV) or other retroviruses, such as the feline sarcoma virus. However, the presence of viral particles within tumor lesions has only been demonstrated by electron microscopy. The malignant transformation of osteochondromas, most typically to osteosarcoma or chondrosarcoma, has also been attributed to the viral infection. Here we report the case of osteochondromatosis in a 3.5-year-old male domestic European shorthair cat with concurrent FeLV infection confirmed by polymerase chain reaction. Viral RNA was visualized in representative tissues (spleen, mesenteric lymph node, liver, kidney, lung, brain) and in the osteochondromas with RNAscope in situ hybridization, which supports that FeLV infection may be involved in the pathogenesis of osteochondromatosis.

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Osteochondroma in a young cat infected by feline leukemia virus

Cited by 3 publications

References 7 publications

A frameshift variant in the EXT1 gene in a feline leukemia virus‐negative cat with osteochondromatosis

A frameshift variant in the EXT1 gene in a feline leukemia virus‐negative cat with osteochondromatosis

Un caso de osteocondroma en la oreja de un gato

In Situ Hybridization of Feline Leukemia Virus in a Case of Osteochondromatosis

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