Osteocalcin, deoxypyridinoline and interleukin‐1β in peri‐implant crevicular fluid of patients with peri‐implantitis

Abstract

The aim of the present study was to analyze the levels of osteocalcin, deoxypyridinoline (Dpd) and interleukin-1beta as markers of bone metabolism in peri-implant crevicular fluid (PICF) from peri-implantitis patients. PICF was sampled from a total of 34 endosseous titanium implants from 16 patients; nine females (mean age 52.8, range 40-62 years) and seven males (mean age 56.0, range 36-66 years). The implants had been in place for a period of 9-112 months (mean; 35.8 months) since the loading. These sites were categorized as six peri-implantitis, eight peri-implant mucositis and 20 healthy implant. PICF volume from peri-implantitis sites was significantly higher than mucositis and healthy implant sites (P < 0.01). Osteocalcin levels in PICF from mucositis sites were significantly higher than healthy implants (P < 0.05), whereas peri-implantitis sites were not significantly different from either mucositis or healthy implant sites. Dpd could not be detected in any of the samples examined. IL-1beta levels in PICF from peri-implantitis sites were significantly higher than levels from peri-implant mucositis (P < 0.05) and healthy implant sites (P < 0.01). In conclusion, osteocalcin in PICF may reflect increased local bone turnover around implants. Further, IL-1beta should be a useful marker for peri-implant inflammation.

Peri-Implant Infections of Oral Biofilm Etiology

“…However, the presence of a specific SNP does not necessarily translate into higher levels of IL-1β in PICF (Lachmann et al 2007;Jansson et al 2005;Melo et al 2012). Although there is good evidence of the involvement of IL-1β as a crucial mediator of the host inflammatory response in peri-implant tissues (Murata et al 2002;Salvi et al 2010;Ataoglu et al 2002), this needs to be complemented with further interventional studies, whereby IL-1β inhibitors are part of the treatment. Moreover, other members of the IL-1 family, such as IL-18, which may display differential regulation from IL-1β, should also be considered in PICF (Hamedi et al 2009;Bostanci et al 2009).…”

“…A few studies looking into other markers of bone metabolism, such as osteocalcin, reported that these are higher in PICF from peri-implant mucositis compared to healthy sites, whereas no differences were observed between periimplatitis and either mucositis or health. Hence, elevated levels of osteocalcin in PICF may 18 reflect increased local bone turnover around implants, rather than severe bone resoprtion (Murata et al 2002).…”

A Comparison Of Il-1β, E2 (Pge2), Pai-2 and Tnf-Α Levels in Gingival Crevicular Fluid (Gcf) and Peri-Implant Crevicular Fluid (Picf) from Groups of Patients with Healthy Teeth, Healthy Implants, Periodontitis and Peri-Implantitis

“…TNF-α stimulates bone resorption and fibroblasts to produce collagenase [29,30]. The detected levels of TNF-α in this study were very low for all four groups.…”

Increased IL-6 Levels in Peri-Implant Crevicular Fluid Correlate with Peri-Implantitis

“…Biochemical markers in peri-implant crevicular fluid may indicate peri-implantitis in early stage, allowing efficient intervention before substantial amounts of bone are lost. Some biochemical markers have been suggested to detect peri-implant disease (17)(18)(19)(20).…”