Osteocalcin as a biochemical marker of bone turnover

Polak−Jonkisz, Dorota; Zwołińska, Danuta

doi:10.1111/j.1440-1797.1998.tb00369.x

Cited by 23 publications

(17 citation statements)

References 26 publications

(6 reference statements)

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“…It seems that these two factors are associated with bone formation, but the mechanism of this formation is still unclear. OCN is known as serum markers reflecting osteoblast activities including bone formation and turnover [26]. In the current study, tanshinol remarkably recovered OVX-induced up-regulation of ALP, OCN and TRACP-5b, which indicated a protective role of tanshinol in OVX-induced bone turnover.…”

Section: Discussionsupporting

confidence: 66%

Effects of tanshinol on markers of bone turnover in ovariectomized rats and osteoblast cultures

Han

Wang

2017

PLoS ONE

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This study was aimed to explore the role of tanshinol in osteoblastic cells, and the role in vivo using an ovariectomized (OVX) rat model of osteoporosis. MC3T3-E1 cells were pretreated with 0–400 μg/mL tanshinol, and then cell viability, apoptosis, alkaline phosphatase (ALP) activity and the expressions of Collagen Type I Alpha 1 (Col1A1), Runt Related Transcription Factor 2 (Runx2) and osteocalcin (OCN) were respectively detected. Rats underwent OVX surgery was intervened with 5 mg/kg tanshinol or 25 μg/kg β-estradiol (E2) for 12 weeks. The triglycerides (TG), total cholesterol (TC), high and low density lipoprotein cholesterol (HDL-C and LDL-C), ALP, OCN and Tartrate-resistant acid phosphatase-5b (TRACP-5b) contents were measured. Besides, the expressions of main factors in nuclear factor-kappa B (NF-κB) pathway were detected. The results showed that tanshinol significantly promoted MC3T3-E1 cells viability and ALP activity, while inhibited apoptosis (P < 0.05); Col1A1, Runx2 and OCN were all up-regulated by tanshinol (P < 0.05). In OVX rats, the contents of TG, TC, LDL-C, ALP, OCN and TRACP-5b were all increased (P < 0.05), while HDL-C was decreased (P < 0.05). Tanshinol significantly alleviated these aberrant regulations (P < 0.05). Inhibitory subunit of NF-κB (IκBα) and p65 were both remarkably phosphorylated by OVX, while this phosphorylation was partially neutralized by tanshinol (P < 0.05). In conclusion, we demonstrated that tanshinol exerted a bone-protective function by modulating the markers of bone turnover possibly via blocking NF-κB pathway. This study will provide new evidence that tanshinol is a potential therapeutic option for the relief of estrogen deficiency-induced osteoporosis.

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Section: Discussionsupporting

confidence: 66%

Effects of tanshinol on markers of bone turnover in ovariectomized rats and osteoblast cultures

Han

Wang

2017

PLoS ONE

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“…Of note, OC also rose significantly, but this could be for many reasons. Although OC is generally categorized as a marker of bone formation and correlates well with other formation markers in healthy individuals, increases in OC could reflect greater rates of turnover or remodeling as opposed to greater rates of bone formation or bone mass accretion, especially when resorption markers are also increased (35). Several mechanisms may explain the increase in turnover rates favoring resorption seen in the APLD group with the greatest effect possibly being attributed to low dietary calcium and vitamin D intakes and subsequently higher PTH levels.…”

Section: Discussionmentioning

confidence: 99%

Diets Higher in Dairy Foods and Dietary Protein Support Bone Health during Diet- and Exercise-Induced Weight Loss in Overweight and Obese Premenopausal Women

Josse

Atkinson

Tarnopolsky

et al. 2012

The Journal of Clinical Endocrinology & Metabolism

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“…OC is known as serum markers reflecting osteoblast activities including bone formation and turnover [19]. The effects of treatment with CSS, SR, and CS on OC level was shown in Table 2.…”

Section: Effect Of Css On Plasma Proteinsmentioning

confidence: 99%

The Mechanism of Cordyceps sinensis and Strontium in Prevention of Osteoporosis in Rats

Wei

Wang²,

Guo³

et al. 2010

Biol Trace Elem Res

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The effects of Cordyceps sinensis (Caterpillar fungus) and strontium ranelate on ovariectomized osteopenic rats was studied in this paper. After the rats were treated orally with C. sinensis, strontium, and C. sinensis rich in strontium ranelate (CSS) respectively, serum alkaline phosphatase (ALP), tartarate-resistant acid phosphatase (TRAP), serum osteocalcin (OC), homocysteine, C-terminal crosslinked telopeptides of collagen type I (CTX), estradiol, and interferon-gamma (IFN-γ) level were examined. The beneficial effects of CSS on improvement of osteoporosis in rats were attributable mainly to decrease ALP activity, TRAP activity, CTX level, and IFN-γ level. At the same time, CSS also increase the OC and estradiol level in ovariectomized osteopenic rats. This study demonstrates the value of C. sinensis rich in strontium ranelate in the management of postmenopausal osteoporosis in humans.

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Osteocalcin as a biochemical marker of bone turnover

Cited by 23 publications

References 26 publications

Effects of tanshinol on markers of bone turnover in ovariectomized rats and osteoblast cultures

Effects of tanshinol on markers of bone turnover in ovariectomized rats and osteoblast cultures

Diets Higher in Dairy Foods and Dietary Protein Support Bone Health during Diet- and Exercise-Induced Weight Loss in Overweight and Obese Premenopausal Women

The Mechanism of Cordyceps sinensis and Strontium in Prevention of Osteoporosis in Rats

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