The Mechanism of Cordyceps sinensis and Strontium in Prevention of Osteoporosis in Rats

Wei, Qi; Wang, Pu-jie; Guo, Wenjun; Yan, Ya‐Bo; Zhang, Yang; Lei, Wei

doi:10.1007/s12011-010-8829-4

Cited by 11 publications

(4 citation statements)

References 26 publications

(25 reference statements)

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“…In a rat ovariectomy model of estrogen deficiency, OVX caused significant increase in bone remodeling after 12 weeks of treatment. This finding agrees with those of other investigators [25, 26]. Furthermore, OVX significantly increased the level of RANKL and decreased the OPG level as well as the OPG/RANKL ratio in serum, demonstrating that the efficiency of ECH in OVX bone loss was mainly associated with the enhancing bone formation and inhibiting bone resorption probably through increasing the ratio of OPG/RANKL.…”

Section: Discussionsupporting

confidence: 93%

Efficacy and Safety of Echinacoside in a Rat Osteopenia Model

Yang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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This study aimed to investigate the efficacy and safety of echinacoside (ECH) using an osteopenia rat model. Forty-eight 6-month-old female Sprague-Dawley rats were randomly divided into one sham-operated group (SHAM) and five OVX (ovariectomized) subgroups: SHAM with vehicle 0.5% carboxymethylcellulose sodium (0.5% CMC-Na) and OVX with vehicle (OVX), OVX with 17β-estradiol (E2), and OVX with ECH of graded doses (ECH-L, ECH-M, and ECH-H). The effects of ECH and E2 on serum biochemical parameters, bone mineral density (BMD), bone biomechanical properties, bone microarchitecture, and immunohistochemistry were examined, and safety assessments were also evaluated. The results showed that ECH treatments improved total femur BMD, bone microarchitecture, and biomechanical properties and decreased serum marker levels in comparison to OVX group. Moreover, ECH administration significantly increased osteoprotegerin (OPG) level, and decreased receptor activator of nuclear factor-κB ligand (RANKL) level in serum, as well as in proximal femur. Importantly, ECH treatment ameliorated the lipid parameters without the overall incidences of adverse events of uterus and mammary gland compared to OVX and SHAM groups. This study demonstrated that administration of ECH for 12 weeks can effectively and safely prevent OVX-induced osteoporosis in rats via increasing the OPG/RANKL ratio.

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Section: Discussionsupporting

confidence: 93%

Efficacy and Safety of Echinacoside in a Rat Osteopenia Model

Yang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…C. sinensis rich in strontium ranelate reduced bone loss in experimental OVX osteopenic rats, in which a decrease in alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP) activities, a decrease in the interferon gamma (IFN-γ) level, and an increase in the osteocalcin (OC) and estradiol levels in plasma were observed [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

Effect of Cordyceps spp. and Cordycepin on Functions of Bones and Teeth and Related Processes: A Review

et al. 2022

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Cordyceps spp. (belonging to the Ascomycota group) are entomopathogenic mushrooms that have traditionally been used in ethnomedicine in Asian countries such as China, Japan, Korea, and India. They are unique parasites of larvae of selected species of moths. Cordyceps militaris is one of the best sources of cordycepin. Worldwide, osteoporosis is one of the most common bone diseases, whose pharmacotherapy includes various medical interventions; however, the research and development of new molecules and new drugs is required. The impact of adenosine receptors (ARs) on the purinergic signaling pathway may regulate proliferation, differentiate dental pulp stem cells and bone marrow, and modulate osteogenesis and bone repair. The aim of the review was to collect and analyze the available data on the effects of Cordyceps spp. or cordycepin on bone function and related processes. To the best of our knowledge, this is the first systematic review in this perspective, not necessarily using mushroom raw material or even the isolated parent compound cordycepin, but new molecules that are analogs of nucleosides, such as those from C. militaris. This review found that Cordyceps spp. or isolated cordycepin interacts via the AR, 5′ adenosine monophosphate-activated protein kinase (AMPK), and adenosine-5′-triphosphate (ATP) signaling pathway and evaluated their impact on bones, teeth, and dental pulp. Cordyceps spp. was found to have the potential to develop regenerative medicines, thus providing an opportunity to expand the treatment or intervention methods in the recovery after traumatic injuries, convalescence, and terminal-stage or devastating diseases.

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“…When ovariectomized rats were treated with cordyceps together with strontium, beneficial effects were obvious, such as improved bone mechanical strength and bone mineral content, and decreased urinary calcium excretion [89]. A follow-up study indicated that the combination treatment led to a decrease in alkaline phosphatase activity, TRAP activity, cross-linked telopeptides of collagen type I level, and interferon-γ level [90]. Using a rat model of disuse-induced bone loss and deterioration of trabecular microarchitecture, researchers have shown that an extract of C. sinensis exerted positive effects on improving the mechanical strength, bone mineral density and bone mineral content [91].…”

Section: Natural Products With Osteoprotective and Related Activitiesmentioning

confidence: 99%

Natural Products from Chinese Medicines with Potential Benefits to Bone Health

2016

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Abstract:Osteoporosis is a progressive, systemic bone disorder characterized by loss of bone mass and microstructure, leading to reduced bone strength and increased risk of fracture. It is often associated with reduced quality of life and other medical complications. The disease is common in the aging population, particularly among postmenopausal women and patients who receive long-term steroidal therapy. Given the rapid growth of the aging population, increasing life expectancy, the prevalence of bone loss, and financial burden to the healthcare system and individuals, demand for new therapeutic agents and nutritional supplements for the management and promotion of bone health is pressing. With the advent of global interest in complementary and alternative medicine and natural products, Chinese medicine serves as a viable source to offer benefits for the improvement and maintenance of bone health. This review summarizes the scientific information obtained from recent literatures on the chemical ingredients of Chinese medicinal plants that have been reported to possess osteoprotective and related properties in cell-based and/or animal models. Some of these natural products (or their derivatives) may become promising leads for development into dietary supplements or therapeutic drugs.

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The Mechanism of Cordyceps sinensis and Strontium in Prevention of Osteoporosis in Rats

Cited by 11 publications

References 26 publications

Efficacy and Safety of Echinacoside in a Rat Osteopenia Model

Efficacy and Safety of Echinacoside in a Rat Osteopenia Model

Effect of Cordyceps spp. and Cordycepin on Functions of Bones and Teeth and Related Processes: A Review

Natural Products from Chinese Medicines with Potential Benefits to Bone Health

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