Osteoblasts and fibroblasts attachment to poly(3-hydroxybutyric acid-co-3-hydrovaleric acid) (PHBV) film and electrospun scaffolds

Kaniuk, Łukasz; Krysiak, Zuzanna J.; Metwally, Sara; Stachewicz, Urszula

doi:10.1016/j.msec.2020.110668

Cited by 44 publications

(31 citation statements)

References 40 publications

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“…In the second sub-type, the drug is dissolved or dispersed in an adhesive layer which is in contact with the skin [ 6 ]. Fibrous membranes, scaffolds, and patches have been widely utilized in tissue engineering [ 7 , 8 , 9 ], hemostats [ 10 ], tendon repair [ 11 ], drug delivery systems for wound healing [ 12 , 13 ], and in the face masks applications [ 14 , 15 ]. Importantly, the scaffold must show adequate mechanical properties, to provide robust support to the damaged tissue.…”

Section: Introductionmentioning

confidence: 99%

Electrospun PCL Patches with Controlled Fiber Morphology and Mechanical Performance for Skin Moisturization via Long-Term Release of Hemp Oil for Atopic Dermatitis

et al. 2020

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Atopic dermatitis (AD) is a chronic, inflammatory skin condition, caused by wide genetic, environmental, or immunologic factors. AD is very common in children but can occur at any age. The lack of long-term treatments forces the development of new strategies for skin regeneration. Polycaprolactone (PCL) is a well-developed, tissue-compatible biomaterial showing also good mechanical properties. In our study, we designed the electrospun PCL patches with controlled architecture and topography for long-term release in time. Hemp oil shows anti-inflammatory and antibacterial properties, increasing also the skin moisture without clogging the pores. It can be used as an alternative cure for patients that do not respond to traditional treatments. In the study, we tested the mechanical properties of PCL fibers, and the hemp oil spreading together with the release in time measured on skin model and human skin. The PCL membranes are suitable material as patches or bandages, characterized by good mechanical properties and high permeability. Importantly, PCL patches showed release of hemp oil up to 55% within 6 h, increasing also the skin moisture up to 25%. Our results confirmed that electrospun PCL patches are great material as oil carriers indicating a high potential to be used as skin patches for AD skin treatment.

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Section: Introductionmentioning

confidence: 99%

Electrospun PCL Patches with Controlled Fiber Morphology and Mechanical Performance for Skin Moisturization via Long-Term Release of Hemp Oil for Atopic Dermatitis

et al. 2020

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“…The porosity can be controlled via fiber size governed by electrospinning parameters, as well as the application of various collectors [10]. This technique allows the fabrication of both random and aligned fibers for different applications with a wide range of sizes from nano to micrometers, which influence different cell behavior on manufactured material [7,[11][12][13]. Aligned fibers fabricated via electrospinning were applied to build the ligament tissue based on the hierarchical structure [14].…”

Section: Introductionmentioning

confidence: 99%

“…Materials 2020,13, 1974; doi:10.3390/ma13081974 www.mdpi.com/journal/materials Materials 2020,13, 1974 …”

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confidence: 99%

Hierarchical Composite Meshes of Electrospun PS Microfibers with PA6 Nanofibers for Regenerative Medicine

et al. 2020

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One of the most frequently applied polymers in regenerative medicine is polystyrene (PS), which is commonly used as a flat surface and requires surface modifications for cell culture study. Here, hierarchical composite meshes were fabricated via electrospinning PS with nylon 6 (PA6) to obtain enhanced cell proliferation, development, and integration with nondegradable polymer fibers. The biomimetic approach of designed meshes was verified with a scanning electron microscope (SEM) and MTS assay up to 7 days of cell culture. In particular, adding PA6 nanofibers changes the fibroblast attachment to meshes and their development, which can be observed by cell flattening, filopodia formation, and spreading. The proposed single-step manufacturing of meshes controlled the surface properties and roughness of produced composites, allowing governing cell behavior. Within this study, we show the alternative engineering of nondegradable meshes without post-treatment steps, which can be used in various applications in regenerative medicine. supervision, U.S.; project administration, U.S.; funding acquisition, U.S. All authors have read and agreed to the published version of the manuscript.

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“…ese are 100% biodegradable polymers, and they have several applications in different areas. Polyhydroxyalkanoates (PHA) is a class of polymers which is made from renewable sources synthesized by bacteria from carbon and oxygen [208,209]. In this class, PHB is the most widely studied and useful biopolymer.…”

Section: Biodegradable Polymer Nanocompositesmentioning

confidence: 99%

“…In this class, PHB is the most widely studied and useful biopolymer. But it has some disadvantages like it is very brittle, cost of production is very high, it does not have any resistance to thermal degradation, and it has a high melting point, due to which it is not suitable for industrial applications [209][210][211][212].…”

Section: Biodegradable Polymer Nanocompositesmentioning

confidence: 99%

Dielectric Properties of ZnO-Based Nanocomposites and Their Potential Applications

Kaur

Bharti

Sharma

et al. 2021

International Journal of Optics

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Energy storage devices constitute one of the research areas in recent years. Capacitors are commonly used for the storage of electrical energy. The current research is focusing on not only the improvement in energy density but also the materials which are environment friendly. Polymer composites are known to be technically essential materials owing to their wide range of applications. Enormous research has been devoted to zinc oxide- (ZnO-) based polymer nanocomposites, due to their extraordinary dielectric properties. This review article presents a detailed study of the dielectric properties of ZnO-based nanocomposites. The dielectric constant study includes the effect of transition metals and rare earth metals as a dopant in ZnO. This review gives an insight into the mechanism responsible for the variation of dielectric constant in ZnO nanocomposites due to various factors like size of nanoparticles, thickness of the thin film, operating frequency, doping concentration, and atomic number. The observations have been summarized to convey the mechanism and structural changes involved in the ZnO nanocomposites to the researchers. The deployment of biodegradable nanocomposite materials is expected to open an innovative way for their outstanding electronic applications as storage materials.

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Osteoblasts and fibroblasts attachment to poly(3-hydroxybutyric acid-co-3-hydrovaleric acid) (PHBV) film and electrospun scaffolds

Cited by 44 publications

References 40 publications

Electrospun PCL Patches with Controlled Fiber Morphology and Mechanical Performance for Skin Moisturization via Long-Term Release of Hemp Oil for Atopic Dermatitis

Electrospun PCL Patches with Controlled Fiber Morphology and Mechanical Performance for Skin Moisturization via Long-Term Release of Hemp Oil for Atopic Dermatitis

Hierarchical Composite Meshes of Electrospun PS Microfibers with PA6 Nanofibers for Regenerative Medicine

Dielectric Properties of ZnO-Based Nanocomposites and Their Potential Applications

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