Osteoblastic cell behaviour on modified titanium surfaces

Łukaszewska-Kuska, Magdalena; Wirstlein, Przemysław; Majchrowski, Radomir; Dorocka‐Bobkowska, Barbara

doi:10.1016/j.micron.2017.11.010

Cited by 47 publications

(51 citation statements)

References 45 publications

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“…Surface treatments aiming at the modification of physical features lead inevitably to the modification of chemical properties, too. In case of the MiPo samples, corundum blasting resulted in an incorporation of AL 2 O 3 remnants which was also described by others (Lukaszewska‐Kuska, Wirstlein, Majchrowski, & Dorocka‐Bobkowska, ). Lukaszewska‐Kuska et al have demonstrated the biocompatibility of such AL 2 O 3 containing surfaces in terms of viability, morphology, and differentiation of osteoblastic cells in comparison to smooth titanium and tissue culture polystyrene (Lukaszewska‐Kuska et al, ).…”

Section: Discussionsupporting

confidence: 79%

Evaluation of topographical and chemical modified TiAl6V4 implant surfaces in a weight‐bearing intramedullary femur model in rabbit

et al. 2019

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For cementless total joint replacement implants, the biological response to physicochemical surface characteristics is crucial for their success that depends on fixation by newly formed bone. In this study, the surface of TiAl6V4 (Tilastan®) implants was modified by (a) corundum blasting, (b) corundum blasting followed by electrochemical calcium phosphate (CaP) deposition, and (c) titanium plasma spraying followed by electrochemical CaP deposition. All modifications resulted in a surface roughness suitable to enhance primary implant stabilization and to favor osteoblast adhesion and function; the thin, biomimetic CaP coating is characterized by fast resorbability and served as chemical cue to stimulate osteogenesis. After implantation in a full weight‐bearing rabbit intramedullary distal femur model, osseointegration was investigated after 3, 6, and 12 weeks. For all modifications, new bone formation, occurring from the endosteum of the femoral cortical bone, was observed in direct contact to the implant surface after 3 weeks. At the later time points, maturation of the woven bone into lamellar bone with clearly defined osteons was visible; the remodeling process was accelerated by the CaP coating. The ingrowth of newly formed bone into the pores of the titanium plasma sprayed surfaces indicates a strong interlock and finally implant fixation. Our findings indicate a positive impact of the tested surface modifications on osseointegration.

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Section: Discussionsupporting

confidence: 79%

Evaluation of topographical and chemical modified TiAl6V4 implant surfaces in a weight‐bearing intramedullary femur model in rabbit

et al. 2019

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“…Several investigations to improve or accelerate the process of osseointegration have been studied, as well worked on to elaborate new treatments for the surface of the implants (micro topography) with different physical and chemical characteristics [5][6][7][8][9]. These modifications have shown good results, mainly in pre-clinical studies, as reported in the literature [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

New Implant Macrogeometry to Improve and Accelerate the Osseointegration: An In Vivo Experimental Study

et al. 2019

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A new implant design with healing chambers in the threads was analyzed and compared with a conventional implant macrogeometry, both implants models with and without surface treatment. Eighty conical implants were prepared using commercially pure titanium (grade IV) by the company Implacil De Bortoli (São Paulo, Brazil). Four groups were performed, as described below: Group 1 (G1), traditional conical implants with surface treatment; group 2 (G2), traditional conical implants without surface treatment (machined surface); group 3 (G3), new conical implant design with surface treatment; group 4 (G4), new conical implant design without surface treatment. The implants were placed in the two tibias (n = 2 implants per tibia) of twenty New Zealand rabbits determined by randomization. The animals were euthanized after 15 days (Time 1) and 30 days (Time 2). The parameters evaluated were the implant stability quotient (ISQ), removal torque values (RTv), and histomorphometric evaluation to determine the bone to implant contact (%BIC) and bone area fraction occupancy (BAFO%). The results showed that the implants with the macrogeometry modified with healing chambers in the threads produced a significant enhancement in the osseointegration, accelerating this process. The statistical analyses of ISQ and RTv showed a significative statistical difference between the groups in both time periods of evaluation (p ≤ 0.0001). Moreover, an important increase in the histological parameters were found for groups G3 and G4, with significant statistical differences to the BIC% (in the Time 1 p = 0.0406 and in the Time 2 p < 0.0001) and the BAFO% ((in the Time 1 p = 0.0002 and in the Time 2 p = 0.0045). In conclusion, the result data showed that the implants with the new macrogeometry, presenting the healing chambers in the threads, produced a significant enhancement in the osseointegration, accelerating the process.

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“…1,2 Different implant geometries and surfaces as well as host site conditions may affect the interface development and its characteristics. 3,4 Many strategies have been used to improve osseointegration and to shorten the healing period of titanium implants. One of those strategies is changing bioinert titanium surface into bioactive one.…”

Section: Introductionmentioning

confidence: 99%

Effects of a hydroxyapatite coating on the stability of endosseous implants in rabbit tibiae

Łukaszewska-Kuska¹,

Krawczyk²,

Martyła³

et al. 2019

Dent. Med. Probl.

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Background. A dental implant surface which would promote rapid and strong osseointegration is a key factor of success in modern implantology. To achieve this goal, different implant surface modifications are developed. A hydroxyapatite (HA) coating changing a bioinert titanium surface into bioactive is one of them. Objectives. The objective of the study was to investigate the effects on bone osseointegration in rabbits resulting from the application of a HA coating deposited on titanium endosseous implants using a modified electrochemical method. Material and methods. Titanium implants with HA coatings and controls with Al 2 O 3 grit-blasted surfaces were embedded into rabbit tibiae. The chemical composition, roughness and morphology of the implants were determined. Implant stability tests were performed, and the Periotest ® value (PTV) and the implant stability quotient (ISQ) value for Osstell Mentor were recorded in order to evaluate the osseointegration. Results. The surface characterization of the implants revealed a microstructure with an arithmetical mean height (Sa) in the range of 0.71-1.04 µm. The HA coating was free of contamination, whereas the controls were enriched with corundum. After healing, a statistically significant increase in the mean ISQ and a decrease in the mean PTV for the HA-coated implants was observed. In the case of the control implants, only PTV decreased significantly with time. Conclusions. The present study found that implant surface properties affected implant stability as determined by Osstell and Periotest measurements. The HA coating reported herein was found to have chemical and physical properties which appear to improve osseointegration compared to grit-blasted implants.

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Osteoblastic cell behaviour on modified titanium surfaces

Cited by 47 publications

References 45 publications

Evaluation of topographical and chemical modified TiAl6V4 implant surfaces in a weight‐bearing intramedullary femur model in rabbit

Evaluation of topographical and chemical modified TiAl6V4 implant surfaces in a weight‐bearing intramedullary femur model in rabbit

New Implant Macrogeometry to Improve and Accelerate the Osseointegration: An In Vivo Experimental Study

Effects of a hydroxyapatite coating on the stability of endosseous implants in rabbit tibiae

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