Osteoblast Lineage Support of Hematopoiesis in Health and Disease

Kim, Matthew J.; Valderrábano, Rodrigo J.; Wu, Joy Y.

doi:10.1002/jbmr.4678

Cited by 7 publications

(3 citation statements)

References 191 publications

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“…A number of “in vitro” and “in vivo” studies have consistently shown a two-way influence between skeletal cells and hematopoietic system [ 24 ]. RDW, a parameter related to erythropoiesis that measures variation in erythrocytes’ size, is considered a marker of biological aging; therefore, it is straightforward its evaluation in osteoporosis, a typical disease of aging population.…”

Section: Discussionmentioning

confidence: 99%

Study of the link between hemotopoietic and skeletal systems in patients attending a referral center for osteoporosis

Pepe

Colangelo

Martino

et al. 2023

J Endocrinol Invest

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Purpose To investigate the link between hematopoietic and skeletal tissues in patients with fragility fractures. Methods We retrospectively analyzed the medical records of women older than 40 years who attended the Bone Disease Unit of “Sapienza” University of Rome for their first visit for osteoporosis from January 2020 to June 2022. Results Fragility fractures were found in 61.8% of the sample. In particular, vertebral fractures in 35.5%, femoral fractures in 6.3%, Colles fractures in 16.5% and non-vertebral non-hip in 42.5%. Fractured patients were significantly older compared to non-fractured, had lower mean values of lumbar spine (p = 0.01), and femoral neck BMD (p = 0.007). A red blood cell distribution width (RDW) value higher than 15% was observed four times more in those with fractures compared to non-fractured patients (8.9% vs 2%, p = 0.01) and was associated with vertebral fracture after adjusting for age, BMI, menopause, nutritional status, smoking, osteoporosis and anemia (OR = 4.1, 95% CI 1.6–11.4, p = 0.003). Hematocrit was negatively associated with hip fracture also adjusting for age, BMI, menopause, nutritional status, smoking, osteoporosis (p = 0.025). Conclusion Our study demonstrates that RDW values were significantly associated with vertebral fracture and hematocrit with hip fracture. Since both parameters are included in the initial evaluation of patients with suspected bone fragility, our results should push doctors to look at these values with no incremental cost for national health services.

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Section: Discussionmentioning

confidence: 99%

Study of the link between hemotopoietic and skeletal systems in patients attending a referral center for osteoporosis

Pepe

Colangelo

Martino

et al. 2023

J Endocrinol Invest

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“…On top, availability of ions, such as calcium, and the extracellular matrix, which is enriched with various growth factors, cytokines, adhesion molecules, and other signals, direct the properties and function of HSCs. Several studies have linked osteogenic cells, in particular osteoblasts, to HSCs, showing that HSCs home to endosteal niches, osteoblast numbers correlate with HSC numbers, and osteogenic cells produce factors, such as CXC chemokine ligand 12 (CXCL12), stem cell factor (SCF), granulocyte colony-stimulating factor (G-CSF), N-cadherin, angiopoietin-1, connexins, and Wnt and Notch signaling pathway components, which regulate HSC quiescence, proliferation, migration, and function [ 57 , 58 ]. Many of the original findings were meanwhile largely confirmed with latest technologies [ 59 – 64 ].…”

Section: The Aging Osteo-hematopoietic Nichementioning

confidence: 99%

Clonal hematopoiesis and its impact on the aging osteo-hematopoietic niche

Winter,

Götze,

Hecker

et al. 2024

Leukemia

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Clonal hematopoiesis (CH) defines a premalignant state predominantly found in older persons that increases the risk of developing hematologic malignancies and age-related inflammatory diseases. However, the risk for malignant transformation or non-malignant disorders is variable and difficult to predict, and defining the clinical relevance of specific candidate driver mutations in individual carriers has proved to be challenging. In addition to the cell-intrinsic mechanisms, mutant cells rely on and alter cell-extrinsic factors from the bone marrow (BM) niche, which complicates the prediction of a mutant cell’s fate in a shifting pre-malignant microenvironment. Therefore, identifying the insidious and potentially broad impact of driver mutations on supportive niches and immune function in CH aims to understand the subtle differences that enable driver mutations to yield different clinical outcomes. Here, we review the changes in the aging BM niche and the emerging evidence supporting the concept that CH can progressively alter components of the local BM microenvironment. These alterations may have profound implications for the functionality of the osteo-hematopoietic niche and overall bone health, consequently fostering a conducive environment for the continued development and progression of CH. We also provide an overview of the latest technology developments to study the spatiotemporal dependencies in the CH BM niche, ideally in the context of longitudinal studies following CH over time. Finally, we discuss aspects of CH carrier management in clinical practice, based on work from our group and others.

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“…87 Cumulative evidence indicates that osteoblasts can specifically secrete a variety of cytokines that are involved in hematopoietic stem cell (HSC) regulation. [88][89][90][91] For instance, conditional ablation of osteoblasts in transgenic mice resulted in a lower HSC number and markedly reduced B cells, which implied that osteoblasts were able to support B-cell differentiation from HSCs. Further studies have demonstrated that IL-7 and CXC motif chemokine 12 (CXCL12) secreted by osteoblasts are implicated in this process.…”

Section: Regulation Of the Immune System By Bone Cellsmentioning

confidence: 99%