Osteoarticular complications of brucellosis.

Colmenero, Juan; Reguera, J.M.; Fernández‐Nebro, Antonio; Cabrera-Franquelo, F

doi:10.1136/ard.50.1.23

Cited by 123 publications

(109 citation statements)

References 28 publications

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“…3,6,7 Spondylitis is one of the most frequently a ected sites in adults, accounting for between 20% to 60% of osteoarticular complications, the lumbar segment being the most commonly a ected level, varying in frequency from 44% to 76% according to di erent studies. 6,8 ± 10 Although brucella spondylitis is considered a mild form of infectious spondylitis in some reports, 11,12 in others, and in our case report, it caused highly destructive lesions.…”

Section: Discussionmentioning

confidence: 99%

“…5 ± 7 The best results have been obtained with doxycycline and streptomycin treatment so far. 3 Lifeso et al 6 suggested that the duration of therapy was more important than the antibiotic agent itself. Surgical drainage is usually recommended along with prolonged antibiotic treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Osteoarticular complications are important owing to their high prevalence and also associated sequela. 2,3 Sacroiliitis and spondylitis are the most frequently seen osteoarticular involvement in adult patients. 4,5 We report a case of a male patient receiving methotrexate and steroid therapy because of formerly diagnosed rheumatoid arthritis who developed highly destructive vertebral lesions and neurological de®cits along with paravertebral and epidural abscesses due to brucellosis.…”

Section: Introductionmentioning

confidence: 99%

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Paravertebral abscess formation and knee arthritis due to Brucellosis in a patient with rheumatoid arthritis

Duyur¹,

Erdem²,

Özgöçmen

2001

Spinal Cord

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Paravertebral abscess formation and knee arthritis due to Brucellosis in a patient with rheumatoid arthritis

Duyur¹,

Erdem²,

Özgöçmen

2001

Spinal Cord

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“…However, there appears to be no statistical difference between groups with regard to C-reactive protein [40]. Therapeutic failure is three-times higher in osteoarthricular brucellosis compared to brucellosis cases without osteoarthricular complaints [40,43,44]. …”

Section: Pathogenesis Clinical Presentation and Risk Factor In Humansmentioning

confidence: 99%

Comparisons of brucellosis between human and veterinary medicine

Hull

Schumaker

2018

Infection Ecology & Epidemiology

128

129

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Brucellosis is the world’s most widespread zoonosis, but also ranks as one of the seven most neglected diseases, according to the World Health Organization. Additionally, it is recognized as the world’s most common laboratory-acquired infection. There are a reported 500,000 incident cases of human brucellosis per year. However, true incidence is estimated to be 5,000,000 to 12,500,000 cases annually. Once diagnosed, focus is directed at treating individual patients with antibiotic regimes, yet overall neglecting the animal reservoir of disease. Countries with the highest incidence of human brucellosis are Syria (1,603.4 cases per 1,000,000 individuals), Mongolia (391.0), and Tajikistan (211.9). Surveillance on animal populations is lacking in many developed and developing countries. According to the World Animal Health Information Database, Mexico had the largest number of reported outbreaks, 5,514 in 2014. Mexico is followed by China (2,138), Greece (1,268), and Brazil (1,142). The majority of these outbreaks is Brucella abortus, the etiologic agent of bovine brucellosis. Brucellosis is an ancient disease that still plagues the world. There are still knowledge gaps and a need for better diagnostics and vaccines to make inroads towards control and eradication.

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“…Localized and complicated forms of brucellosis can cause severe morbidity and require prolonged medical treatment. As many as 25% to 80% of patients develop rheumatic problems with subsequent functional impairment 411. The diagnosis of brucellosis arthritis can be established by signs and symptoms of arthritis (pain, tenderness, swelling of the joint) in the presence of an antibody titer greater than 1:160 in the tube agglutination test or by a positive culture 12…”

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confidence: 99%

Epidemiological and clinical features of Brucella arthritis in 24 children

Zamani

Kooraki

Mohazab

et al. 2011

Annals of Saudi Medicine

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BACKGROUND AND OBJECTIVES:Brucellosis is considered the leading zoonotic disease of the Middle East. The disease has a wide spectrum of clinical manifestations and can result in complications with severe morbidity. The aim of this study was to evaluate the frequency, distribution and characteristics of arthritis in Iranian children with brucellosis.DESIGN AND SETTING:A retrospective descriptive study conducted in a referral children center in Tehran from 1997 to 2005.PATIENTS AND METHODS:Arthritis in children with brucellosis who were admitted to a specialized hospital was detected by clinical signs of the involved joint(s) and characteristics of joint fluid aspiration. Socio-demographic information was recorded.RESULTS:Of 96 patients diagnosed with brucellosis, 24 (25%) had Brucella arthritis 14 (58.3%) males and 10 (41.7%) females. Most common manifestations were fever in 21 patients (87.5%) and fatigue in 18 patients (75%). Monoarthritis was recorded in 15 patients (62.5%) of the cases with involvement of the knee in 8 (45%) and hip in 5 (29%), the ankle in 2 (8%) patients while 9 (37.5%) patients suffered from polyarthritis. None of the patients had axial joints involvement. Seventy-five percent of the subjects (18 patients) were from urban areas and 66.7% (16 patients) had consumed un-pasteurized cheese. Recurrence was not seen in any of the 24 patients who received a combination of co-trimoxazole for 6 weeks and gentamicin for 5 days.CONCLUSION:Childhood brucellosis is a challenging disease in Iran that has serious complications like arthritis. Therefore all physicians who work in endemic areas should be familiar with this disease and consider the possibility of brucellosis in all children who present with arthritis and arthralgia.

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Osteoarticular complications of brucellosis.

Cited by 123 publications

References 28 publications

Paravertebral abscess formation and knee arthritis due to Brucellosis in a patient with rheumatoid arthritis

Paravertebral abscess formation and knee arthritis due to Brucellosis in a patient with rheumatoid arthritis

Comparisons of brucellosis between human and veterinary medicine

Epidemiological and clinical features of Brucella arthritis in 24 children

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