Osteoarthritis year in review 2015: imaging

Wang, Y.; Teichtahl, Andrew; Cicuttini, Flavia Maria

doi:10.1016/j.joca.2015.07.027

Cited by 32 publications

(18 citation statements)

References 71 publications

(92 reference statements)

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“…With little doubt, OA pathogenesis is multifactorial including genetic disposition, low grade inflammation and biomechanical factors 10 . OA also seems to impact general health reflected in a prospective study of more than 5000 hip OA patients where an association between hip OA and increased risk of all-cause and cardiovascular mortality over a period of 16 years was fund 28 .…”

Section: Prognosis/predictive Valuementioning

confidence: 99%

Osteoarthritis year in review 2016: imaging

Boesen

Ellegaard

Henriksen

et al. 2017

Osteoarthritis and Cartilage

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Section: Prognosis/predictive Valuementioning

confidence: 99%

Osteoarthritis year in review 2016: imaging

Boesen

Ellegaard

Henriksen

et al. 2017

Osteoarthritis and Cartilage

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“…Being non-invasive and sensitive to the molecular motions, magnetic resonance imaging (MRI) has undisputable potential to become the leading diagnostic tool for cartilage health (11)(12)(13)(14)(15)(16)(17)(18)(19). Several MRI protocols can in principle detect the early changes in OA cartilage, for example, T2 and T2 anisotropy, T1ρ, T1 with the use of contrast agent, and diffusion (20)(21)(22)(23)(24)(25).…”

Section: Original Articlementioning

confidence: 99%

Image interpolation improves the zonal analysis of cartilage T2 relaxation in MRI

Badar

Xia

2017

Quant. Imaging Med. Surg.

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Background: This project aimed to investigate the improvement in the detection of osteoarthritis (OA) in cartilage by the interpolation of T2 images, in the situation when the native MRI resolution is insufficient to resolve the depth-dependent T2 characteristics in articular cartilage (AC).Methods: Eighteen intact canine knee joints that were healthy or had mild (contralateral) or severe OA were T2-imaged in a 7T/20 cm MRI system at 200 µm/pixel resolution (macro-MRI). Two image analysis methods were used to interpolate the images to 100 µm/pixel, i.e., by Fourier-transforming the time-domain FID (Free Induction Decay) signal using the Varian NMR software and by interpolating the 2D T2 image using the ImageJ software. and the interpolated 100 µm resolutions were subdivided into two equal-thickness regions and three-equal thickness regions based on clinical MRI protocols. A new method divided the T2 profiles into three-unequal thickness zones according to the T2 profiles at 17.6 µm/pixel from the same cartilage imaged in a 7 Tesla/9 cm µMRI system. Both interpolation methods improved the depth-dependent T2 images/profiles in macro-MRI. The unequal zone division in T2 had better OA sensitivity than the equal zone division. The threeequal zone division of T2 profiles had better OA sensitivity than the two-equal zone division. The statistical significant difference between the healthy and mild OA cartilage is detected (P=0.0018) only by the unequal zone division method at 100 µm resolution.Conclusions: Data interpolation improves the T2 sensitivity in MRI of cartilage OA. Unequal division of tissue thickness enables better early stage of OA detection than the equal division.

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“…Osteoarthritis (OA) is estimated to become the fourth leading cause of disability worldwide by 2020 (Puopolo et al, 2007). Established OA is considered to be a whole-organ structural disease, which includes cartilage, bone, synovium, capsule and other structures (Wang, Teichtahl, & Cicuttini, 2016). Epidemiological studies involving many OA patients suggested that an inflammatory synovium/synovitis was linked to increased cartilage damage and pain (de Lange-Brokaar et al, 2014;Haseeb & Haqqi, Haqqi, 2013).…”

Section: Introductionmentioning

confidence: 99%

The COX‐2 inhibitor etoricoxib reduces experimental osteoarthritis and nociception in rats: The roles of TGF‐β1 and NGF expressions in chondrocytes

Wen

Lin

Chang

et al. 2019

European Journal of Pain

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Background Osteoarthritis (OA) is the most common joint disease, especially affecting the knee joint. Etoricoxib, a highly selective cyclooxygenase (COX)‐2 inhibitor which can reduce postoperative pain after orthopaedic surgery. The aim of this study was to investigate the effects of oral etoricoxib on the development of OA and to examine concomitant changes in the nociceptive behaviour of rats. Method OA was induced in wistar rats by anterior cruciate ligament transection (ACLT) of the right knee. The ACLT + etoricoxib groups received 6.7 or 33.3 mg/kg of oral etoricoxib three times a week for 12 consecutive weeks, starting at week 8 after ACLT. Nociceptive behaviours and changes in knee joint width during OA development were analyzed. Histopathological studies were then performed on the cartilage. Immunohistochemical analysis was performed to examine the effect of etoricoxib on the expression of transforming growth factor‐beta (TGF‐β) and nerve growth factor (NGF) in articular cartilage chondrocytes. Results OA rats receiving etoricoxib showed a significantly lower degree of cartilage degeneration than the rats receiving placebo. Nociceptive behaviour studies showed significant improvement in the ACLT + etoricoxib groups compared to that in the ACLT group. Moreover, etoricoxib attenuated NGF expression, but increased TGF‐β expression, in OA‐affected cartilage. Conclusions Oral etoricoxib in a rat OA model (a) attenuates the development of OA, (b) concomitantly reduces nociception, and (c) modulates chondrocyte metabolism, possibly by inhibiting NGF expression and increasing TGF‐β expression. Significance Oral administration of etoricoxib can attenuate the development of OA, with an associated attenuation of nociceptive behaviour in an experimental rat OA model. Moreover, etoricoxib attenuated NGF expression, but enhanced TGF‐β expression in OA‐affected chondrocytes. These findings may pave the way for further investigations of etoricoxib as a potential therapeutic target for the treatment of the inflammatory component in OA.

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Osteoarthritis year in review 2015: imaging

Cited by 32 publications

References 71 publications

Osteoarthritis year in review 2016: imaging

Osteoarthritis year in review 2016: imaging

Image interpolation improves the zonal analysis of cartilage T2 relaxation in MRI

The COX‐2 inhibitor etoricoxib reduces experimental osteoarthritis and nociception in rats: The roles of TGF‐β1 and NGF expressions in chondrocytes

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